Blue Jays vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 6:11 p.m.

Friday's slate in the MLB includes a matchup between the Toronto Blue Jays and the Cincinnati Reds.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding this matchup.

Blue Jays vs Reds Game Info

• Toronto Blue Jays (77-82) vs. Cincinnati Reds (74-85)
• Date: Friday, September 25, 2026
• Time: 7:07 p.m. ET
• Venue: Rogers Centre -- Toronto, Ontario
• Coverage: SNET and Reds.TV

Blue Jays vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TOR: (-154) | CIN: (+130)
• Spread: TOR: -1.5 (+146) | CIN: +1.5 (-176)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Blue Jays vs Reds Probable Starting Pitchers

Probable Pitchers: José Soriano (Blue Jays) - 12-8, 3.77 ERA vs Nick Lodolo (Reds) - 3-6, 5.04 ERA

The Blue Jays will give the nod to Jose Soriano (12-8, 3.77 ERA), who is eyeing win No. 13 on the season, and the Reds will counter with Nick Lodolo (3-6, 5.04 ERA). Soriano and his team are 17-12-0 ATS this season when he starts. Soriano's team has a record of 7-5 this season when he starts and they are the favorite on the moneyline. The Reds have an 8-12-0 record against the spread in Lodolo's starts. The Reds have been the moneyline underdog in 15 of Lodolo's starts this season, and they went 6-9 in those matchups.

Blue Jays vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Blue Jays win (64.6%)

Blue Jays vs Reds Moneyline

• Toronto is a -154 favorite on the moneyline, while Cincinnati is a +130 underdog on the road.

Blue Jays vs Reds Spread

• The Reds are +1.5 on the spread (-176 to cover), and Toronto is +146 to cover the runline.

Blue Jays vs Reds Over/Under

• The over/under for the Blue Jays versus Reds contest on Sept. 25 has been set at 7.5, with -115 odds on the over and -105 odds on the under.

Bet on Toronto Blue Jays vs. Cincinnati Reds on FanDuel today!

Blue Jays vs Reds Betting Trends

• The Blue Jays have won in 41, or 52.6%, of the 78 contests they have been named as odds-on favorites in this year.
• Toronto has a record of 12-9 in contests when bookmakers favor them by -154 or more on the moneyline.
• The Blue Jays and their opponents have gone over the total this season in 80 of their 154 opportunities.
• The Blue Jays have posted a record of 74-80-0 against the spread this season.
• The Reds have been the underdog on the moneyline 111 total times this season. They've gone 52-59 in those games.
• Cincinnati has gone 16-26 when it has played as a moneyline underdog with odds of +130 or longer (38.1%).
• The Reds have played in 155 games with a set over/under, and have combined with their opponents to go over the total 82 times (82-71-2).
• The Reds have put together an 80-75-0 record against the spread this season.

Blue Jays Player Leaders

• Vladimir Guerrero Jr. leads Toronto with an OBP of .335 this season while batting .263 with 56 walks and 71 runs scored. He has a slugging percentage of .360.
• Among the qualified hitters in the majors, his batting average ranks 52nd, his on-base percentage ranks 59th, and he is 122nd in slugging.
• Guerrero hopes to build on a five-game hitting streak in this matchup. In his last five games he is batting .313 with a double and two walks.
• Kazuma Okamoto leads Toronto with 130 hits. He is batting .232 this season and has 57 extra-base hits. He's also slugging .452 with an on-base percentage of .307.
• He ranks 110th in batting average, 108th in on-base percentage and 42nd in slugging among qualifying hitters.
• Ernie Clement has hit nine homers with a team-high .371 SLG this season.
• George Springer has 15 home runs, 54 RBI and a batting average of .251 this season.
• Springer has safely hit in two straight games. During his last five outings he is batting .176 with an RBI.

Reds Player Leaders

• Sal Stewart has racked up a team-best .465 slugging percentage. He's batting .266 with an on-base percentage of .334.
• Including all the qualifying hitters in MLB, his batting average is 47th, his on-base percentage ranks 63rd, and he is 35th in slugging.
• Elly De La Cruz has 156 hits with a .367 OBP to lead his team in both. He has a batting average of .285 while slugging .521.
• Including all qualifying hitters, he is 14th in batting average, 15th in on-base percentage and eighth in slugging percentage.
• JJ Bleday is hitting .215 with 16 doubles, two triples, 23 home runs and 71 walks.
• Eugenio Suarez is hitting .209 with 17 doubles, 25 home runs and 52 walks.

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