Blue Jays vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 1:11 a.m.

The Friday schedule in MLB includes a matchup between the Toronto Blue Jays and the Cincinnati Reds.

We've got you covered, in terms of the most important info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Blue Jays vs Reds Game Info

• Toronto Blue Jays (77-82) vs. Cincinnati Reds (74-85)
• Date: Friday, September 25, 2026
• Time: 7:07 p.m. ET
• Venue: Rogers Centre -- Toronto, Ontario
• Coverage: SNET and Reds.TV

Blue Jays vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TOR: (-136) | CIN: (+116)
• Spread: TOR: -1.5 (+172) | CIN: +1.5 (-210)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Blue Jays vs Reds Probable Starting Pitchers

Probable Pitchers: José Soriano (Blue Jays) - 12-8, 3.77 ERA vs Nick Lodolo (Reds) - 3-6, 5.04 ERA

The probable pitchers are Jose Soriano (12-8) for the Blue Jays and Nick Lodolo (3-6) for the Reds. Soriano and his team have a record of 17-12-0 against the spread when he starts. Soriano's team is 7-5 this season when he starts and they are the moneyline favorite. The Reds have an 8-12-0 record against the spread in Lodolo's starts. The Reds have a 6-9 record in Lodolo's 15 starts this season when they were the moneyline underdog.

Blue Jays vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Blue Jays win (65%)

Blue Jays vs Reds Moneyline

• The Blue Jays vs Reds moneyline has Toronto as a -136 favorite, while Cincinnati is a +116 underdog on the road.

Blue Jays vs Reds Spread

• The Blue Jays are favored by 1.5 runs at home versus the Reds. The Blue Jays are +172 to cover the spread, while the Reds are -210.

Blue Jays vs Reds Over/Under

• The over/under for Blue Jays-Reds on Sept. 25 is 7.5. The over is -115, and the under is -105.

Bet on Toronto Blue Jays vs. Cincinnati Reds on FanDuel today!

Blue Jays vs Reds Betting Trends

• The Blue Jays have been victorious in 41, or 52.6%, of the 78 contests they have been chosen as favorites in this season.
• Toronto has a record of 20-19 when favored by -136 or more this year.
• The Blue Jays and their opponents have gone over the total this season in 80 of their 154 opportunities.
• The Blue Jays are 74-80-0 against the spread in their 154 games with a line set by sportsbooks this season.
• The Reds have put together a 52-59 record in games they were the underdog on the moneyline (winning 46.8% of those games).
• When playing as a moneyline underdog with odds of +116 or longer, Cincinnati has a 26-34 record (winning 43.3% of its games).
• The Reds have combined with opponents to hit the over on the total 82 times this season for an 82-71-2 record against the over/under.
• The Reds have an 80-75-0 record ATS this season (covering 51.6% of the time).

Blue Jays Player Leaders

• Vladimir Guerrero Jr. has 140 hits this season and a team-best OBP of .335. He has a .263 batting average and a slugging percentage of .360.
• Among qualifying batters in baseball, his batting average ranks 53rd, his on-base percentage ranks 59th, and he is 122nd in slugging.
• Guerrero hopes to build on a five-game hitting streak in this matchup. During his last five outings he is hitting .313 with a double and two walks.
• Kazuma Okamoto has 130 hits, which ranks first among Toronto batters this season. He's batting .232 with 57 extra-base hits. He's also slugging .452 with an on-base percentage of .307.
• Among qualifying hitters, his batting average ranks him 110th, his on-base percentage 108th, and his slugging percentage 41st.
• Ernie Clement has an OPS of .660, fueled by an OBP of .290 and a team-best slugging percentage of .371 this season.
• George Springer is batting .251 with a .323 OBP and 54 RBI for Toronto this season.
• Springer brings a two-game hitting streak into this matchup. In his last five games he is hitting .176 with an RBI.

Reds Player Leaders

• Sal Stewart has racked up a slugging percentage of .465, a team-best for the Reds. He's batting .266 with an on-base percentage of .334.
• Including all qualified players in the majors, his batting average places him 46th, his on-base percentage is 64th, and he is 35th in slugging.
• Elly De La Cruz leads his team with 156 hits and a .367 OBP. He has a batting average of .285 while slugging .521.
• Including all qualifying hitters, he is 14th in batting average, 15th in on-base percentage and eighth in slugging percentage.
• JJ Bleday is hitting .215 with 16 doubles, two triples, 23 home runs and 71 walks.
• Eugenio Suarez is batting .209 with 17 doubles, 25 home runs and 52 walks.

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