Bills vs Lions Prediction, Odds, Picks, Best Bets for NFL Week 2 Thursday Night Football

The NFL slate on Thursday includes the Buffalo Bills facing the Detroit Lions.

We've got you covered, in terms of the most important info about NFL betting lines, before you make your wager on FanDuel Sportsbook.

Bills vs Lions Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Bills win (64.5%)

Bills vs Lions Point Spread

The Bills are 5.5-point favorites against the Lions. The Bills are -112 to cover the spread, while the Lions are -108 to cover as a 5.5-point underdog.

Bills vs Lions Over/Under

An over/under of 54.5 has been set for Bills-Lions on Sept. 17, with the over being -114 and the under -106.

Bills vs Lions Moneyline

Looking at the moneyline for Lions-Bills, Detroit is the underdog at +210, and Buffalo is -255 playing at home.

Bills vs Lions Betting Trends

• The Bills beat the spread eight times in 17 games last year.
• The Bills' ATS record as 5.5-point favorites or greater was 4-7 last season.
• Out of 17 Buffalo games last season, nine went over the total.
• The Lions had eight wins in 17 games against the spread last year.
• Detroit didn't have a win ATS (0-1) as 5.5-point or larger underdogs last season.
• In 17 Lions games last season, 10 of them went over the total.

Check out even more in-depth Bills vs. Lions analysis on FanDuel Research.

Bills vs Lions Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BUF: (-255) | DET: (+210)
• Spread: BUF: -5.5 (-112) | DET: +5.5 (-108)
• Total: 54.5 -- Over: (-114) | Under: (-106)

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