Best College Football Games Week 4: Predictions, Odds, Picks, Best Bets

Top-25 teams will be in action in 18 games on the Week 4 college football schedule. That includes the No. 6 Tennessee Volunteers squaring off against the No. 15 Oklahoma Sooners at Gaylord Family Oklahoma Memorial Stadium.

For analysis of all the important games in college football this weekend, read our betting preview below.

Nebraska vs. Illinois

• Matchup: No. 24 Illinois Fighting Illini at No. 22 Nebraska Cornhuskers
• Projected Favorite: Nebraska (63.24% win probability)
• Spread: Nebraska (-9.5)
• Total: 42.5
• Time: 8:00 PM ET
• Date: Sept. 20
• TV Channel: FOX

Bet on Nebraska vs. Illinois with FanDuel Sportsbook.

Clemson vs. North Carolina State

• Matchup: North Carolina State Wolfpack at No. 21 Clemson Tigers
• Projected Favorite: Clemson (79.68% win probability)
• Spread: Clemson (-17.5)
• Total: 43.5
• Time: 12:00 PM ET
• Date: Sept. 21
• TV Channel: ABC

Bet on Clemson vs. North Carolina State with FanDuel Sportsbook.

Ohio State vs. Marshall

• Matchup: Marshall Thundering Herd at No. 3 Ohio State Buckeyes
• Projected Favorite: Ohio State (97.90% win probability)
• Spread: Ohio State (-39.5)
• Total: 54.5
• Time: 12:00 PM ET
• Date: Sept. 21
• TV Channel: FOX

Bet on Ohio State vs. Marshall with FanDuel Sportsbook.

Iowa State vs. Arkansas State

• Matchup: Arkansas State Red Wolves at No. 20 Iowa State Cyclones
• Projected Favorite: Iowa State (90.49% win probability)
• Spread: Iowa State (-20.5)
• Total: 51.5
• Time: 2:00 PM ET
• Date: Sept. 21
• TV Channel: ESPN+

Bet on Iowa State vs. Arkansas State with FanDuel Sportsbook.

Michigan vs. USC

• Matchup: No. 11 USC Trojans at No. 18 Michigan Wolverines
• Projected Favorite: Michigan (53.03% win probability)
• Spread: USC (-4.5)
• Total: 44.5
• Time: 3:30 PM ET
• Date: Sept. 21
• TV Channel: CBS

Bet on Michigan vs. USC with FanDuel Sportsbook.

Louisville vs. Georgia Tech

• Matchup: Georgia Tech Yellow Jackets at No. 19 Louisville Cardinals
• Projected Favorite: Louisville (81.33% win probability)
• Spread: Louisville (-8.5)
• Total: 56.5
• Time: 3:30 PM ET
• Date: Sept. 21
• TV Channel: ESPN2

Bet on Louisville vs. Georgia Tech with FanDuel Sportsbook.

Notre Dame vs. Miami (OH)

• Matchup: Miami (OH) RedHawks at No. 17 Notre Dame Fighting Irish
• Projected Favorite: Notre Dame (95.97% win probability)
• Spread: Notre Dame (-27.5)
• Total: 44.5
• Time: 3:30 PM ET
• Date: Sept. 21
• TV Channel: NBC

Bet on Notre Dame vs. Miami (OH) with FanDuel Sportsbook.

Penn State vs. Kent State

• Matchup: Kent State Golden Flashes at No. 10 Penn State Nittany Lions
• Projected Favorite: Penn State (98.04% win probability)
• Spread: Penn State (-48.5)
• Total: 57.5
• Time: 3:30 PM ET
• Date: Sept. 21
• TV Channel: BTN

Bet on Penn State vs. Kent State with FanDuel Sportsbook.

Northern Illinois vs. Buffalo

• Matchup: Buffalo Bulls at No. 23 Northern Illinois Huskies
• Projected Favorite: Northern Illinois (79.78% win probability)
• Spread: Northern Illinois (-13.5)
• Total: 43.5
• Time: 3:30 PM ET
• Date: Sept. 21
• TV Channel: ESPN+

Bet on Northern Illinois vs. Buffalo with FanDuel Sportsbook.

LSU vs. UCLA

• Matchup: UCLA Bruins at No. 16 LSU Tigers
• Projected Favorite: LSU (78.99% win probability)
• Spread: LSU (-21.5)
• Total: 56.5
• Time: 3:30 PM ET
• Date: Sept. 21
• TV Channel: ABC

Bet on LSU vs. UCLA with FanDuel Sportsbook.

Oklahoma State vs. Utah

• Matchup: No. 12 Utah Utes at No. 14 Oklahoma State Cowboys
• Projected Favorite: Utah (59.16% win probability)
• Spread: Oklahoma State (-1.5)
• Total: 53.5
• Time: 4:00 PM ET
• Date: Sept. 21
• TV Channel: FOX

Bet on Oklahoma State vs. Utah with FanDuel Sportsbook.

Missouri vs. Vanderbilt

• Matchup: Vanderbilt Commodores at No. 7 Missouri Tigers
• Projected Favorite: Missouri (96.61% win probability)
• Spread: Missouri (-17.5)
• Total: 51.5
• Time: 4:15 PM ET
• Date: Sept. 21
• TV Channel: SEC Network

Bet on Missouri vs. Vanderbilt with FanDuel Sportsbook.

South Florida vs. Miami (FL)

• Matchup: No. 8 Miami (FL) Hurricanes at South Florida Bulls
• Projected Favorite: Miami (FL) (86.63% win probability)
• Spread: Miami (FL) (-16.5)
• Total: 64.5
• Time: 7:00 PM ET
• Date: Sept. 21
• TV Channel: ESPN

Bet on South Florida vs. Miami (FL) with FanDuel Sportsbook.

Oklahoma vs. Tennessee

• Matchup: No. 6 Tennessee Volunteers at No. 15 Oklahoma Sooners
• Projected Favorite: Tennessee (50.37% win probability)
• Spread: Tennessee (-5.5)
• Total: 56.5
• Time: 7:30 PM ET
• Date: Sept. 21
• TV Channel: ABC

Bet on Oklahoma vs. Tennessee with FanDuel Sportsbook.

Texas A&M vs. Bowling Green

• Matchup: Bowling Green Falcons at No. 25 Texas A&M Aggies
• Projected Favorite: Texas A&M (94.30% win probability)
• Spread: Texas A&M (-22.5)
• Total: 50.5
• Time: 7:30 PM ET
• Date: Sept. 21
• TV Channel: SEC Network+

Bet on Texas A&M vs. Bowling Green with FanDuel Sportsbook.

Ole Miss vs. Georgia Southern

• Matchup: Georgia Southern Eagles at No. 5 Ole Miss Rebels
• Projected Favorite: Ole Miss (98.04% win probability)
• Spread: Ole Miss (-35.5)
• Total: 68.5
• Time: 7:45 PM ET
• Date: Sept. 21
• TV Channel: SEC Network

Bet on Ole Miss vs. Georgia Southern with FanDuel Sportsbook.

Texas vs. Louisiana-Monroe

• Matchup: Louisiana-Monroe Warhawks at No. 1 Texas Longhorns
• Projected Favorite: Texas (97.36% win probability)
• Spread: Texas (-43.5)
• Total: 53.5
• Time: 8:00 PM ET
• Date: Sept. 21
• TV Channel: SEC Network+

Bet on Texas vs. Louisiana-Monroe with FanDuel Sportsbook.

BYU vs. Kansas State

• Matchup: No. 13 Kansas State Wildcats at BYU Cougars
• Projected Favorite: Kansas State (77.73% win probability)
• Spread: Kansas State (-7.5)
• Total: 49.5
• Time: 10:30 PM ET
• Date: Sept. 21
• TV Channel: ESPN

Bet on BYU vs. Kansas State with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

New to FanDuel Sportsbook? You’ll receive $200 in Bonus Bets guaranteed after your first bet of $5+ is placed! See here for full terms and conditions. Learn about today’s other offers at FanDuel Sportsbook Promos.