Astros vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 2

Odds updated as of 2:12 a.m.

The Houston Astros versus the Chicago White Sox is on the MLB schedule for Wednesday.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Astros vs White Sox Game Info

• Houston Astros (70-69) vs. Chicago White Sox (73-65)
• Date: Wednesday, September 2, 2026
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and CHSN

Astros vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-142) | CHW: (+120)
• Spread: HOU: -1.5 (+150) | CHW: +1.5 (-182)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Astros vs White Sox Probable Starting Pitchers

Probable Pitchers: Hayden Wesneski (Astros) - 4-1, 3.86 ERA vs Davis Martin (White Sox) - 9-6, 4.32 ERA

This contest's pitching matchup is set, as the Astros will send Hayden Wesneski (4-1) to the mound, while Davis Martin (9-6) will get the nod for the White Sox. Wesneski and his team are 5-1-0 ATS this season when he starts. When Wesneski starts a game and his team is the favorite on the moneyline, they have a record of 4-1. The White Sox have gone 13-11-0 ATS in Martin's 24 starts with a set spread. The White Sox are 10-5 in Martin's 15 starts this season that they were the moneyline underdog.

Astros vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (55.6%)

Astros vs White Sox Moneyline

• Chicago is the underdog, +120 on the moneyline, while Houston is a -142 favorite at home.

Astros vs White Sox Spread

• The White Sox are +1.5 on the spread (-182 to cover), and Houston is +150 to cover the runline.

Astros vs White Sox Over/Under

• The over/under for the Astros versus White Sox contest on Sept. 2 has been set at 8.5, with -105 odds on the over and -115 odds on the under.

Bet on Houston Astros vs. Chicago White Sox on FanDuel today!

Astros vs White Sox Betting Trends

• The Astros have been favorites in 59 games this season and have come away with the win 30 times (50.8%) in those contests.
• This season Houston has been victorious eight times in 25 chances when named as a favorite of at least -142 on the moneyline.
• The Astros and their opponents have gone over the total this season in 72 of their 139 opportunities.
• The Astros have an against the spread record of 67-72-0 in 139 games with a line this season.
• The White Sox are 49-50 in games they were listed as the moneyline underdog (winning 49.5% of those games).
• Chicago has gone 25-30 in games it has played as a moneyline underdog with odds of +120 or longer (45.5%).
• The White Sox have played in 135 games with an over/under set, and have combined with opponents to go over the total 75 times (75-59-1).
• The White Sox have gone 79-56-0 against the spread this season.

Astros Player Leaders

• Yordan Alvarez has 155 hits and an OBP of .433 to go with a slugging percentage of .603. All three of those stats are tops among Houston hitters this season. He has a .316 batting average, as well.
• Among all qualified hitters in MLB, his batting average ranks second, his on-base percentage ranks first, and he is first in slugging.
• Isaac Paredes is hitting .256 with 23 doubles, a triple, 18 home runs and 59 walks, while slugging .421 with an on-base percentage of .355.
• He ranks 65th in batting average, 37th in on-base percentage and 69th in slugging in the major leagues.
• Paredes has picked up at least one hit in two games in a row. In his last five games he is batting .118 with a home run, four walks and an RBI.
• Christian Walker has collected 112 base hits, an OBP of .302 and a slugging percentage of .427 this season.
• Jeremy Pena has 17 home runs, 46 RBI and a batting average of .281 this season.

White Sox Player Leaders

• Miguel Vargas is batting .251 with 30 doubles, a triple, 29 home runs and 86 walks. He's slugging .488 with an on-base percentage of .365.
• Including all the qualified hitters in MLB, he ranks 80th in batting average, 24th in on-base percentage and 24th in slugging percentage.
• Vargas hopes to build on a three-game hitting streak in this matchup. In his last five games he is batting .263 with four walks.
• Chase Meidroth is slugging .401 to lead his team. He has a batting average of .273 with an on-base percentage of .347.
• He is currently 38th in batting average, 46th in on-base percentage and 93rd in slugging percentage among all qualified hitters.
• Sam Antonacci has an on-base percentage of .366, a team-high for the White Sox.
• Tristan Peters has 27 doubles, three triples, 12 home runs and 33 walks while hitting .276.

Astros vs White Sox Head to Head

• 9/1/2026: 5-1 CHW (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/31/2026: 6-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +118)
• 7/26/2026: 12-3 CHW (Favorite: White Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/25/2026: 4-1 HOU (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/24/2026: 9-5 HOU (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/12/2025: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -275, Underdog Moneyline: +225)
• 6/11/2025: 10-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/10/2025: 4-2 CHW (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 5/4/2025: 5-4 CHW (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/3/2025: 8-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -235, Underdog Moneyline: +194)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!