Astros vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for April 20

Odds updated as of 7:11 p.m.

The MLB's Sunday schedule includes the Houston Astros taking on the San Diego Padres.

All the information you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Astros vs Padres Game Info

• Houston Astros (10-10) vs. San Diego Padres (15-6)
• Date: Sunday, April 20, 2025
• Time: 7:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: ESPN

Astros vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-118) | SD: (-100)
• Spread: HOU: +1.5 (-205) | SD: -1.5 (+168)
• Total: 7.5 -- Over: (-100) | Under: (-122)

Astros vs Padres Probable Starting Pitchers

Probable Pitchers: Framber Valdez (Astros) - 1-2, 4.91 ERA vs Dylan Edward Cease (Padres) - 1-1, 6.64 ERA

The Astros will look to Framber Valdez (1-2) against the Padres and Dylan Edward Cease (1-1). When Valdez starts, his team is 2-2-0 against the spread this season. Valdez's team has a record of 1-2 this season when he starts and they are the favorite on the moneyline. The Padres are 2-2-0 against the spread when Cease starts. The Padres have not been a moneyline underdog when Cease starts this season.

Astros vs Padres Moneyline

• Houston is a -118 favorite on the moneyline, while San Diego is a -100 underdog on the road.

Astros vs Padres Spread

• The Padres are 1.5-run favorites against the spread for this matchup with the Astros. The Padres are +168 to cover, while the Astros are -205 to cover as a 1.5-run underdog on the runline.

Astros vs Padres Over/Under

• Astros versus Padres, on April 20, has an over/under of 7.5, with the over being -100 and the under -122.

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Astros vs Padres Betting Trends

• The Astros have been chosen as favorites in 12 games this year and have walked away with the win six times (50%) in those games.
• Houston has a record of 6-5 in contests when sportsbooks favor them by -118 or more on the moneyline.
• The Astros and their opponents have hit the over in eight of their 20 games with a total set by oddsmakers this season.
• The Astros are 10-10-0 against the spread in their 20 games that had a posted line this season.
• The Padres have won four of the eight games they were the underdog on the moneyline this season (50%).
• San Diego has a 4-3 record (winning 57.1% of its games) when playing as a moneyline underdog of -100 or longer.
• The Padres have played in 21 games with a set over/under, and have combined with their opponents to go over the total nine times (9-11-1).
• The Padres have a 14-7-0 record against the spread this season (covering 66.7% of the time).

Astros Player Leaders

• Jeremy Pena is batting .222 with two doubles, three home runs and seven walks. He has an on-base percentage of .305 while slugging .375.
• He is 108th in batting average, 105th in on-base percentage, and 101st in slugging among qualified hitters in MLB.
• Pena will look for his 11th straight game with a hit in this matchup. In his last 10 outings he is batting .297 with two doubles, a home run, five walks and five RBI.
• Jose Carlos Altuve leads Houston in slugging percentage (.427) and total hits (25) this season. He's batting .305 with an on-base percentage of .333.
• His batting average is 27th among qualified players, his on-base percentage 73rd, and his slugging percentage 70th.
• Isaac Paredes leads Houston in OBP (.352) this season, fueled by 18 hits.
• Jake Meyers has been key for Houston with 16 hits, an OBP of .344 plus a slugging percentage of .345.

Padres Player Leaders

• Fernando Tatis Jr. has accumulated an on-base percentage of .427, a slugging percentage of .636, and has 27 hits, all club-bests for the Padres (while batting .351).
• Including all qualifying hitters in MLB, he ranks seventh in batting average, seventh in on-base percentage and eighth in slugging percentage.
• Tatis enters this game on an eight-game hitting streak. In his last 10 games he is hitting .333 with six home runs, five walks and nine RBI.
• Manny Machado is hitting .304 with nine doubles, two home runs and eight walks. He's slugging .494 with an on-base percentage of .368.
• Including all qualifying players, he ranks 30th in batting average, 39th in on-base percentage and 35th in slugging percentage.
• Luis Sangel (Reveron) Arraez has three doubles, three home runs and five walks while hitting .287.
• Xander Bogaerts is hitting .254 with seven doubles and 10 walks.

Astros vs Padres Head to Head

• 4/19/2025: 3-2 HOU (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/18/2025: 6-4 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 9/18/2024: 4-0 SD (Favorite: Padres, Spread: -1.5, Total: 6.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/17/2024: 4-3 HOU (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/16/2024: 3-1 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/10/2023: 12-2 HOU (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 9/9/2023: 7-5 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/8/2023: 11-2 SD (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)

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