Astros vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 27

Odds updated as of 11:11 p.m.

The MLB schedule on Sunday includes the Houston Astros facing the Athletics.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Astros vs Athletics Game Info

• Houston Astros (79-81) vs. Athletics (64-96)
• Date: Sunday, September 27, 2026
• Time: 3:05 p.m. ET
• Venue: Sutter Health Park -- West Sacramento, California
• Coverage: NBCS-CA and SCHN

Astros vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-158) | OAK: (+134)
• Spread: HOU: -1.5 (-104) | OAK: +1.5 (-115)
• Total: 9.5 -- Over: (-120) | Under: (-102)

Astros vs Athletics Probable Starting Pitchers

Probable Pitchers: TBA (Astros) vs Brady Basso (Athletics) - 1-3, 0.00 ERA

The Athletics will give the nod to Basso (1-3, 2.31), while the Astros' starting pitcher for this game has not been announced. The Athletics have gone 5-2-0 against the spread when Basso starts. The Athletics are 2-4 in Basso's six starts this season that they were the moneyline underdog.

Astros vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Athletics win (51.4%)

Astros vs Athletics Moneyline

• The Astros vs Athletics moneyline has the Astros as a -158 favorite, while the Athletics are a +134 underdog at home.

Astros vs Athletics Spread

• The Astros are 1.5-run favorites on the runline against the Athletics. The Astros are -104 to cover, while the Athletics are -115 to cover.

Astros vs Athletics Over/Under

• A total of 9.5 runs has been set for the Astros-Athletics game on Sept. 27, with the over available at -120 and the under at -102.

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Astros vs Athletics Betting Trends

• The Astros have been favorites in 70 games this season and have come away with the win 36 times (51.4%) in those contests.
• This season, the Astros have come away with a win eight times in 21 chances when named as a favorite of at least -158 or shorter on the moneyline.
• The Astros and their opponents have hit the over in 79 of their 160 games with a total this season.
• In 160 games with a line this season, the Astros have a mark of 80-80-0 against the spread.
• The Athletics have compiled a 47-74 record in games they were the underdog on the moneyline (winning 38.8% of those games).
• The Athletics have gone 19-36 when they have played as a moneyline underdog with odds of +134 or longer (34.5%).
• The Athletics have combined with their opponents to go over the total 84 times this season for an 84-73-2 record against the over/under.
• The Athletics have put together a 76-83-0 record against the spread this season.

Astros Player Leaders

• Yordan Alvarez leads Houston with 176 hits and an OBP of .433, plus a team-best slugging percentage of .599. He's batting .315.
• Among qualified hitters in MLB, his batting average ranks first, his on-base percentage ranks first, and he is first in slugging.
• Alvarez has recorded at least one hit in 10 straight games. In his last 10 games he is hitting .400 with three doubles, three home runs, eight walks and six RBIs.
• Isaac Paredes has 27 doubles, a triple, 24 home runs and 70 walks. He's batting .260 and slugging .442 with an on-base percentage of .358.
• Among all qualified hitters, he is 62nd in batting average, 33rd in on-base percentage and 52nd in slugging percentage.
• Christian Walker has 126 hits this season and has a slash line of .223/.296/.420.
• Walker brings a four-game hitting streak into this game. In his last five games he is batting .263 with three home runs, two walks and five RBIs.
• Jose Altuve is batting .249 with a .304 OBP and 47 RBI for Houston this season.

Athletics Player Leaders

• Jeff McNeil has a .373 slugging percentage, which leads the Athletics. He's batting .267 with an on-base percentage of .315.
• Including all the qualifying hitters in MLB, he is 45th in batting average, 96th in on-base percentage and 113th in slugging percentage.
• McNeil takes a three-game hitting streak into this game. In his last five games he is hitting .333 with a double, a home run, two walks and five RBIs.
• Zack Gelof is hitting .256 with 16 doubles, two triples, 22 home runs and 31 walks. He's slugging .479 with an on-base percentage of .323.
• Shea Langeliers is batting .263 with 21 doubles, 23 home runs and 36 walks.
• Lawrence Butler has racked up 110 hits with a .326 OBP to pace his team in both.

Astros vs Athletics Head to Head

• 9/25/2026: 6-5 OAK (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -186, Underdog Moneyline: +156)
• 9/24/2026: 7-5 HOU (Favorite: Astros, Spread: -1.5, Total: 10.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 8/23/2026: 7-6 OAK (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +162)
• 8/22/2026: 4-3 OAK (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -235, Underdog Moneyline: +215)
• 8/21/2026: 4-0 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +162)
• 6/7/2026: 5-0 OAK (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/6/2026: 13-2 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/5/2026: 5-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/5/2026: 12-10 OAK (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/4/2026: 11-0 HOU (Favorite: Athletics, Spread: -1.5, Total: 9.5, Favorite Moneyline: -108, Underdog Moneyline: -108)

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