Astros vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 27

Odds updated as of 2:12 p.m.

The Houston Astros versus the Athletics is on the MLB schedule for Sunday.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Astros vs Athletics Game Info

• Houston Astros (80-81) vs. Athletics (64-97)
• Date: Sunday, September 27, 2026
• Time: 3:05 p.m. ET
• Venue: Sutter Health Park -- West Sacramento, California
• Coverage: NBCS-CA and SCHN

Astros vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-158) | OAK: (+134)
• Spread: HOU: -1.5 (-104) | OAK: +1.5 (-115)
• Total: 9.5 -- Over: (-120) | Under: (-102)

Astros vs Athletics Probable Starting Pitchers

Probable Pitchers: Peter Lambert (Astros) - 8-10, 3.87 ERA vs Seth Johnson (Athletics) - 1-0, 6.19 ERA

The Astros will call on Peter Lambert (8-10) versus the Athletics and Seth Johnson (1-0). When Lambert starts, his team is 17-11-0 against the spread this season. Lambert's team has won 61.5% of his starts when they are favored on the moneyline (8-5). Johnson and his team were underdogs on the moneyline in every game he pitched a season ago.

Astros vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (53.6%)

Astros vs Athletics Moneyline

• The Astros vs Athletics moneyline has the Astros as a -158 favorite, while the Athletics are a +134 underdog at home.

Astros vs Athletics Spread

• The Astros are 1.5-run favorites on the runline against the Athletics. The Astros are -104 to cover, while the Athletics are -115 to cover.

Astros vs Athletics Over/Under

• Astros versus Athletics on Sept. 27 has an over/under of 9.5 runs, with the odds on the over -120 and the under set at -102.

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Astros vs Athletics Betting Trends

• The Astros have been victorious in 37, or 52.1%, of the 71 contests they have been chosen as favorites in this season.
• This year, the Astros have won nine of 22 games when listed as at least -158 or better on the moneyline.
• The Astros and their opponents have hit the over in 80 of their 161 games with a total this season.
• The Astros have posted a record of 81-80-0 against the spread this season.
• The Athletics have been the underdog on the moneyline 122 total times this season. They've finished 47-75 in those games.
• When they have played as a moneyline underdog with odds of +134 or longer, the Athletics have a record of 19-36 (34.5%).
• The Athletics have combined with their opponents to go over the total 85 times this season for an 85-73-2 record against the over/under.
• The Athletics have a 76-84-0 record ATS this season (covering 47.5% of the time).

Astros Player Leaders

• Yordan Alvarez has 178 hits and an OBP of .432 to go with a slugging percentage of .604. All three of those stats are tops among Houston hitters this season. He has a .316 batting average, as well.
• He ranks first in batting average, first in on-base percentage, and first in slugging among qualifying hitters in MLB.
• Alvarez will look for his 12th straight game with a hit in this matchup. In his last 10 outings he is batting .395 with four doubles, three home runs, six walks and seven RBIs.
• Isaac Paredes is batting .263 with 27 doubles, a triple, 25 home runs and 70 walks, while slugging .449 with an on-base percentage of .360.
• He is 54th in batting average, 31st in on-base percentage and 47th in slugging among qualifying batters.
• Christian Walker has collected 127 base hits, an OBP of .295 and a slugging percentage of .421 this season.
• Walker brings a five-game hitting streak into this game. In his last five games he is hitting .300 with a double, three home runs, a walk and six RBIs.
• Jeremy Pena has been key for Houston with 122 hits, an OBP of .325 plus a slugging percentage of .477.

Athletics Player Leaders

• Jeff McNeil has a .371 slugging percentage, which leads the Athletics. He's batting .266 with an on-base percentage of .315.
• Including all the qualifying hitters in the big leagues, his batting average places him 47th, his on-base percentage is 96th, and he is 114th in slugging.
• Zack Gelof has 16 doubles, two triples, 22 home runs and 31 walks while hitting .259. He's slugging .479 with an on-base percentage of .325.
• Shea Langeliers is hitting .261 with 21 doubles, 23 home runs and 36 walks.
• Lawrence Butler paces his team with 110 hits and a .325 OBP.

Astros vs Athletics Head to Head

• 9/26/2026: 13-2 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 9/25/2026: 6-5 OAK (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -186, Underdog Moneyline: +156)
• 9/24/2026: 7-5 HOU (Favorite: Astros, Spread: -1.5, Total: 10.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 8/23/2026: 7-6 OAK (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +162)
• 8/22/2026: 4-3 OAK (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -235, Underdog Moneyline: +215)
• 8/21/2026: 4-0 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +162)
• 6/7/2026: 5-0 OAK (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/6/2026: 13-2 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/5/2026: 5-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/5/2026: 12-10 OAK (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -126, Underdog Moneyline: +108)

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