Astros vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 9:11 p.m.

On Friday in MLB, the Houston Astros are up against the Athletics.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this matchup.

Astros vs Athletics Game Info

• Houston Astros (79-80) vs. Athletics (63-96)
• Date: Friday, September 25, 2026
• Time: 9:40 p.m. ET
• Venue: Sutter Health Park -- West Sacramento, California
• Coverage: NBCS-CA and SCHN

Astros vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-186) | OAK: (+156)
• Spread: HOU: -1.5 (-118) | OAK: +1.5 (-102)
• Total: 9.5 -- Over: (+104) | Under: (-128)

Astros vs Athletics Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 6-3, 3.26 ERA vs Jacob Lopez (Athletics) - 6-5, 5.68 ERA

The Astros will look to Hunter Brown (6-3) versus the Athletics and Jacob Lopez (6-5). Brown and his team have a record of 9-10-0 against the spread when he starts. Brown's team has a record of 8-8 this season when he starts and they are the favorite on the moneyline. The Athletics have gone 13-10-0 against the spread when Lopez starts. The Athletics have been the underdog on the moneyline in 21 of Lopez's starts this season, and they went 11-10 in those games.

Astros vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (51.2%)

Astros vs Athletics Moneyline

• The Astros vs Athletics moneyline has the Astros as a -186 favorite, while the Athletics are a +156 underdog at home.

Astros vs Athletics Spread

• The Astros are 1.5-run favorites on the runline against the Athletics. The Astros are -118 to cover, while the Athletics are -102 to cover.

Astros vs Athletics Over/Under

• The over/under for the Astros versus Athletics game on Sept. 25 has been set at 9.5, with +104 odds on the over and -128 odds on the under.

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Astros vs Athletics Betting Trends

• The Astros have been favorites in 69 games this season and have come away with the win 36 times (52.2%) in those contests.
• This year, the Astros have won one of three games when listed as at least -186 or better on the moneyline.
• The Astros and their opponents have hit the over in 78 of their 159 games with a total this season.
• The Astros have posted a record of 80-79-0 against the spread this season.
• The Athletics have won 38.3% of the games this season they were the underdog on the moneyline (46-74).
• In games they have played as a moneyline underdog with odds of +156 or longer, the Athletics have gone 10-20 (33.3%).
• The Athletics have combined with their opponents to go over the total 83 times this season for an 83-73-2 record against the over/under.
• The Athletics have collected a 75-83-0 record ATS this season (covering 47.5% of the time).

Astros Player Leaders

• Yordan Alvarez has 175 hits and an OBP of .432 to go with a slugging percentage of .600. All three of those stats are tops among Houston hitters this season. He has a .315 batting average, as well.
• Among qualifying hitters, he is first in batting average, his on-base percentage ranks first, and he is first in slugging.
• Alvarez has hit safely in nine straight games. In his last 10 outings he is batting .394 with three doubles, three home runs, eight walks and six RBIs.
• Isaac Paredes has 27 doubles, a triple, 24 home runs and 69 walks. He's batting .261 and slugging .445 with an on-base percentage of .359.
• His batting average ranks 58th among qualified players, his on-base percentage 32nd, and his slugging percentage 50th.
• Paredes brings a three-game streak with at least one hit into this one. During his last five outings he is hitting .333 with a double, three home runs, four walks and five RBIs.
• Christian Walker has 125 hits this season and has a slash line of .223/.295/.415.
• Walker takes a three-game hitting streak into this matchup. In his last five games he is batting .300 with two home runs, a walk and four RBIs.
• Jeremy Pena has 20 home runs, 51 RBI and a batting average of .274 this season.
• Pena brings a four-game hitting streak into this matchup. During his last five outings he is batting .182 with a triple.

Athletics Player Leaders

• Jeff McNeil has accumulated a team-best .374 slugging percentage. He's batting .267 with an on-base percentage of .316.
• He is 45th in batting average, 96th in on-base percentage and 112th in slugging percentage among all qualified hitters in the majors.
• Zack Gelof is batting .259 with 16 doubles, two triples, 22 home runs and 31 walks. He's slugging .484 with an on-base percentage of .326.
• Shea Langeliers has 21 doubles, 23 home runs and 35 walks while batting .265.
• Lawrence Butler's 110 hits and .328 on-base percentage both lead his team.

Astros vs Athletics Head to Head

• 9/24/2026: 7-5 HOU (Favorite: Astros, Spread: -1.5, Total: 10.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 8/23/2026: 7-6 OAK (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +162)
• 8/22/2026: 4-3 OAK (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -235, Underdog Moneyline: +215)
• 8/21/2026: 4-0 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +162)
• 6/7/2026: 5-0 OAK (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/6/2026: 13-2 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/5/2026: 5-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/5/2026: 12-10 OAK (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/4/2026: 11-0 HOU (Favorite: Athletics, Spread: -1.5, Total: 9.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/3/2026: 11-4 OAK (Favorite: Athletics, Spread: -1.5, Total: 10, Favorite Moneyline: -108, Underdog Moneyline: -108)

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