Astros vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 21

Odds updated as of 7:12 p.m.

The MLB slate on Friday includes the Houston Astros facing the Athletics.

All the information you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Astros vs Athletics Game Info

• Houston Astros (64-64) vs. Athletics (49-79)
• Date: Friday, August 21, 2026
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and NBCS-CA

Astros vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-255) | OAK: (+210)
• Spread: HOU: -1.5 (-108) | OAK: +1.5 (-111)
• Total: 8 -- Over: (-110) | Under: (-110)

Astros vs Athletics Probable Starting Pitchers

Probable Pitchers: Hayden Wesneski (Astros) - 2-1, 5.16 ERA vs J.T. Ginn (Athletics) - 8-7, 3.53 ERA

The Astros will give the ball to Hayden Wesneski (2-1, 5.16 ERA), who is eyeing win No. 3 on the season, and the Athletics will turn to J.T. Ginn (8-7, 3.53 ERA). Wesneski's team is 3-1-0 against the spread in his starts this season. Wesneski's team has won 75% of his starts when they are favored on the moneyline (3-1). When Ginn starts, the Athletics are 14-8-0 against the spread. The Athletics are 9-6 in Ginn's 15 starts this season that they were the underdog on the moneyline.

Astros vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (55.9%)

Astros vs Athletics Moneyline

• The Astros vs Athletics moneyline has the Astros as a -255 favorite, while the Athletics are a +210 underdog on the road.

Astros vs Athletics Spread

• The Astros are 1.5-run favorites on the runline against the Athletics. The Astros are -108 to cover, while the Athletics are -111 to cover.

Astros vs Athletics Over/Under

• A combined run total of 8 has been set for Astros-Athletics on Aug. 21, with the over at -110 and the under at -110.

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Astros vs Athletics Betting Trends

• The Astros have been victorious in 27, or 50%, of the 54 contests they have been chosen as favorites in this season.
• The Astros have yet to enter a game this year with shorter moneyline odds than -255.
• The Astros and their opponents have hit the over in 68 of their 128 games with a total this season.
• The Astros are 61-67-0 against the spread in their 128 games that had a posted line this season.
• The Athletics have won 36.3% of the games this season they were the underdog on the moneyline (33-58).
• The Athletics have played as a moneyline underdog of +210 or longer in only two games this season, which they split 1-1.
• The Athletics have played in 128 games with a set over/under, and have combined with their opponents to go over the total 64 times (64-62-2).
• The Athletics have gone 58-70-0 against the spread this season.

Astros Player Leaders

• Yordan Alvarez leads Houston with 145 hits and an OBP of .432, plus a team-best slugging percentage of .613. He's batting .319.
• Among qualified batters in baseball, he is first in batting average, first in on-base percentage, and first in slugging.
• Alvarez hopes to build on a two-game hitting streak in this matchup. During his last five outings he is hitting .188 with a double and two walks.
• Isaac Paredes has 22 doubles, a triple, 16 home runs and 49 walks. He's batting .262 and slugging .424 with an on-base percentage of .355.
• Among qualified hitters, he ranks 61st in batting average, 38th in on-base percentage and 71st in slugging percentage.
• Paredes has picked up at least one hit in two straight games. In his last five games he is hitting .438 with a double, a home run, three walks and two RBIs.
• Christian Walker has collected 104 base hits, an OBP of .308 and a slugging percentage of .440 this season.
• Jeremy Pena has been key for Houston with 88 hits, an OBP of .338 plus a slugging percentage of .469.

Athletics Player Leaders

• Jeff McNeil is batting .261 with 16 doubles, six home runs and 25 walks. He's slugging .357 with an on-base percentage of .313.
• Jacob Wilson is batting .266 with 16 doubles, a triple, seven home runs and 12 walks. He's slugging .388 with an on-base percentage of .298.
• Zack Gelof is batting .269 with 12 doubles, a triple, 14 home runs and 20 walks.
• Lawrence Butler has 13 doubles, a triple, 11 home runs and 45 walks while batting .218.

Astros vs Athletics Head to Head

• 6/7/2026: 5-0 OAK (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/6/2026: 13-2 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/5/2026: 5-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/5/2026: 12-10 OAK (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/4/2026: 11-0 HOU (Favorite: Athletics, Spread: -1.5, Total: 9.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/3/2026: 11-4 OAK (Favorite: Athletics, Spread: -1.5, Total: 10, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/25/2025: 11-5 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/24/2025: 6-0 OAK (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/23/2025: 5-1 OAK (Favorite: Athletics, Spread: -1.5, Total: 10, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/27/2025: 7-1 OAK (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)

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