49ers vs Rams Best Bets at a Glance 49ers +3.5 (-102) Brock Purdy 15+ Rushing Yards (-166) Thursday Night Football gives us an intriguing NFC West matchup as the Los Angeles Rams face the San Francisco 49ers in Australia in the second game of the 2026 NFL season. Both teams enter the matchup with plenty of expectations, making this an interesting early-season test for two NFC contenders. With divisional familiarity and plenty of offensive firepower on both sides, there are several betting angles worth considering. Using the NFL odds at FanDuel Sportsbook as a guide, here are the best bets for this game. All NFL projections via our numbers at FanDuel Research, and NFL odds come from FanDuel Sportsbook. Lines may change after this article is published. 49ers vs Rams Props, Prediction, Picks 49ers +3.5 (-102) The Los Angeles Rams have won the offseason, and while they very well may win this game, I’m intrigued by the San Francisco 49ers against the spread at this 3.5 number. These teams split their two meetings a season ago, with Mac Jones leading San Fran to a 26-23 overtime victory in LA