College Basketball Top Upset Predictions March Madness is where upsets define the tournament — and Saturday’s slate is loaded with opportunities to find value on underdogs. If you're searching for the best bets today, March Madness upset predictions, and college basketball picks, this slate features several games where the spread doesn’t fully reflect how competitive the matchup could be. Let’s break down the top upset picks and best bets for today’s NCAA Tournament games. Top Upset Picks for March Madness Today 1. Louisville (+172) vs. Michigan State Spread: Michigan State -4.5 Moneyline: Louisville +172 Total: 150.5 This is one of the strongest upset spots on the board. Why Louisville can win: Balanced scoring across multiple starters Ability to match Michigan State’s physicality Michigan State’s offense can struggle to create separation With a spread under two possessions, this game profiles much closer to a coin flip than the odds suggest. Best Bet: Louisville Moneyline (+172) 2

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