2 Best Bets and Player Prop Bets for Louisville vs Michigan State Round of 32 The NCAA Tournament continues with a tightly lined matchup between Louisville (6) and Michigan State (3) — one of the most competitive games on Saturday’s slate. With a spread under two possessions and a total in the 150 range, this game sets up well for both spread betting and player props tied to usage and minutes. Let’s break down the best bets and top player props for Louisville vs. Michigan State. Louisville vs. Michigan State Odds Spread: Michigan State -4.5 (-110) Moneyline: Louisville +162 / Michigan State -196 Total: 150.5 Betting Preview This matchup features two teams with contrasting strengths: Michigan State: Defense, structure, and physicality Louisville: Offensive balance and shot-making With a relatively tight spread, this game projects to stay competitive deep into the second half — which is key for both spread value and prop volume. Best Bet #1: Louisville +4.5 (-110) This is one of the strongest underdog spots on the board. Why Louisville can cover: Balanced scoring across multiple starters Ability to generate offense in both transition and half-court sets Michigan State’s offense can struggle to create separation In a game likely decided late, getting +4.5 provides valuable margin — especially with Louisville’s ability to keep pace. Best Bet: Louisville +4.5 (-110) Best Bet #2: Over 150.5 (-115) While Michigan State prefers a more controlled style, this total is still within reach. Why the over makes sense: Competitive spread → starters play heavy minutes Louisville’s offense increases pace compared to Michigan State’s typical games Late-game fouling scenarios can push totals higher If this game stays within one or two possessions late, scoring should extend beyond expectation. Best Bet: Over 150.5 (-115) Best Player Props J