Rams vs 49ers Predictions and Expert Picks for Week 6 NFL Sunday Night Football

The Los Angeles Rams (4-1) attempt to win their third game in a row when they travel to the Bay area to take on the division-rival San Francisco 49ers (2-3) this week. Meanwhile, the 49ers have lost two straight games and will look to get their season back on track with a timely upset.

Let's see what the experts are predicting will happen in this Week 6 Rams-49ers Sunday Night Football matchup.

Rams vs 49ers Picks Week 6

CBS Sports picks are from their panel of experts, numberFire picks are from their NFL game projections, Sporting News picks are from Vinnie Iyer, and betting favorites are from FanDuel Sportsbook's Week 6 NFL odds.

Winner:
CBS Sports: Rams (7), 49ers (1)
numberFire: Rams
Sporting News: Rams
Betting Favorite: Rams -3

Against the Spread:
CBS Sports: Rams (6), 49ers (2)
Sporting News: Rams

The experts and analysts expect things to get worse for the 49ers and better for the Rams as they almost unanimously predicted Los Angeles will emerge victorious. A few experts expect the 49ers to keep this game close, but it doesn't look like there is an upset win is brewing this week.

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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.