NFL - Odds & Predictions

Patriots vs Colts Prediction, Odds, Spread, Over/Under & Betting Trends for NFL Week 15 Game on FanDuel Sportsbook

Devon Platana
New England Patriots vs Indianapolis Colts prediction, odds, spread, over/under and betting trends for NFL Week 15 game.
New England Patriots vs Indianapolis Colts prediction, odds, spread, over/under and betting trends for NFL Week 15 game. / Bob Levey/GettyImages
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Patriots vs Colts Week 15 Game Info

NFL Regular Season — Week 15 Game
New England Patriots (9-4, 6-0 Away) vs. Indianapolis Colts (7-6, 3-4 Home)
Date: Saturday, December 18, 2021
Time: 8:15 p.m. EST
Venue: Lucas Oil Stadium — Indianapolis, IN
Coverage: NFL Network

Patriots vs Colts Odds & Spread

All NFL regular betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: NE: (+118) | IND: (-138)
Spread: NE: +2.5 (-108) | IND: -2.5 (-112)
Total: 45.5 — Over: (-110) | Under: (-110)
Odds to Win Super Bowl LVI: NE: (+750) | IND: (+3000)

Patriots vs Colts Prediction & Pick

All NFL predictions and picks are from numberFire's projection model.
Prediction: Indianapolis Colts win (61.2%)

Patriots vs Colts Betting Trends

- New England is 8-0 straight up in its last eight games against Indianapolis.
- Indianapolis is 3-7 against the spread (ATS) in its last 10 home games.
- New England is 16-3-1 ATS in its last 20 road games against Indianapolis.
- The total has hit the over in eight of Indianapolis' last nine games against New England.


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Devon Platana is not a FanDuel employee. The views expressed in his articles are the author's alone and do not necessarily reflect the views of FanDuel.

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