Houston vs Arizona Odds, Predictions & Best Bet Today (Can Cougars Pull Off the Upset?)

Today's slate of March Madness NCAA Tournament Sweet 16 games features a showdown in the South Region between the No. 5 Houston Cougars and No. 1 Arizona Wildcats.

FanDuel Sportsbook has you covered with all the odds you need for the game, and here's a rundown of the betting lines as well as some predictions for tonight's game.

Houston vs Arizona Odds & Point Spread Tonight

Moneyline: HOU: (+105) | ARIZ: (-126)
Spread: HOU: +1.5 (-110) | ARIZ: -1.5 (-110)
Total: 145.5 — Over (-110) | Under (-110)
Odds to Win National Championship: HOU (+850) | ARIZ (+650)

Houston vs Arizona March Madness Prediction & Best Bet

The Houston vs Arizona projection on numberFire gives the Wildcats a 50.3% chance of winning, which actually makes the underdog Cougars the best bet in this game. The +105 moneyline gives the Cougars an implied win probability of 48.8% — lower than numberFire's 49.7% projection.

Of the two schools, Houston has had the more difficult path to the Sweet 16, defeating No. 12 UAB and No. 4 Illinois. Meanwhile, Arizona secured its wins against No. 16 Wright State and No. 9 TCU.

Although Arizona is the higher seed in the matchup, the Wildcats are the No. 3-ranked team, according to KenPom. While that's pretty promising, the Cougars actually rank higher than them at No. 2.

Although Arizona is one of the top teams in the nation for a reason, all signs indicate that Houston is more than capable of pulling off an upset while providing better betting value in the process.

Devon Platana is not a FanDuel employee. The views expressed in his articles are the author's alone and do not necessarily reflect the views of FanDuel.