Colts vs Cardinals Predictions and Expert Picks for Week 16 NFL Game From FanDuel Sportsbook

Week 16's slate of NFL games includes a Saturday clash between the Indianapolis Colts and Arizona Cardinals.

Colts vs Cardinals Prediction and Pick

ESPN picks are from their Football Power Index (FPI) matchup predictor, numberFire picks are from their analytics projection models, FiveThirtyEight picks are from their NFL projections and betting favorites are according to FanDuel Sportsbook's Colts-Cardinals betting odds and lines.

NFL Week 16 Picks Straight Up

ESPN: Cardinals
numberFire: Cardinals
FiveThirtyEight: Cardinals
Betting Favorite: Cardinals (-1.5)

Cardinals vs Colts Prediction

Winner: Cardinals (4)

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Devon Platana is not a FanDuel employee. The views expressed in his articles are the author's alone and do not necessarily reflect the views of FanDuel.