Bills vs Patriots Predictions and Expert Picks for Week 16 Monday Night Football

This AFC East divisional matchup looks very different than it typically would at this point in the season. The Buffalo Bills have won the division and are fighting for playoff position. The New England Patriots are eliminated from the playoff race, so they have very little to play for here.

In this interesting Monday Night Football showdown, it looks one-sided in the NFL odds, but it is always tough to count out the Patriots. To unpack all of this, we'll turn things over to a panel of NFL experts.

Bills vs Patriots Picks Week 16

CBS Sports picks are from their panel of experts, numberFire picks are from their NFL game projections, Sporting News picks are from Vinnie Iyer and betting favorites are from FanDuel Sportsbook's Week 16 NFL odds.

Winner:
CBS Sports: Bills (8), Patriots (0)
numberFire: Bills
Sporting News: Bills
Betting Favorite: Bills -7

Against the Spread:
CBS Sports: Bills (5), Patriots (3)
Sporting News: Bills

All 10 experts are picking the Bills to win this game. However, three of nine experts believe the Patriots will keep the game close enough to cover the spread.

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