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49ers vs Rams Prediction, Odds, Spread, Over/Under & Betting Trends for NFL Week 18 Game on FanDuel

Devon Platana
San Francisco 49ers vs Los Angeles Rams prediction, odds, spread, over/under and betting trends for NFL Week 18 game.
San Francisco 49ers vs Los Angeles Rams prediction, odds, spread, over/under and betting trends for NFL Week 18 game. / Ezra Shaw/GettyImages
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49ers vs Rams Week 18 Game Info

NFL Regular Season — Week 18 Game
San Francisco 49ers (9-7, 5-3 Away) vs. Los Angeles Rams (12-4, 5-2 Home)
Date: Sunday, January 9, 2022
Time: 4:25 p.m. EST
Venue: SoFi Stadium — Inglewood, CA
Coverage: FOX

49ers vs Rams Odds & Spread

All NFL regular betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: SF: (+166) | LAR: (-198)
Spread: SF: +4 (-108) | LAR: -4 (-112)
Total: 48 — Over: (-110) | Under: (-110)
Odds to Win Super Bowl LVI: SF: (+3400) | LAR: (+950)

49ers vs Rams Prediction & Pick

All NFL predictions and picks are from numberFire's projection model.
Prediction: Los Angeles Rams win (57.2%)

49ers vs Rams Betting Trends

- San Francisco is 5-0 straight up in its last five games against the Rams.
- The Rams are 3-7 against the spread (ATS) in their last 10 games against San Francisco.
- The total has hit the under in six of San Francisco's last eight games.
- The total has hit the under in 12 of the Rams' last 15 home games.


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Devon Platana is not a FanDuel employee. The views expressed in his articles are the author's alone and do not necessarily reflect the views of FanDuel.

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