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49ers vs Cardinals Point Spread, Over/Under, Moneyline and Betting Trends for NFL Week 16

Zach Brunner
49ers vs Cardinals point spread, over/under, moneyline and betting trends for Week 16.
49ers vs Cardinals point spread, over/under, moneyline and betting trends for Week 16. / Christian Petersen/Getty Images
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The San Francisco 49ers hit the road to face the Arizona Cardinals at State Farm Stadium in Week 16 NFL action on Saturday.

Here's everything you need to know before placing your bet for this game on FanDuel Sportsbook.

49ers vs Cardinals Point Spread

The 49ers are 5.5-point road underdogs. The Cardinals are 5.5-point home favorites, with -112 odds to cover the spread. San Francisco has -108 odds to cover.

49ers vs Cardinals Over/Under

The over/under for the 49ers vs Cardinals Week 16 NFL matchup is set at 48.5 total points, with -110 odds on both the over and the under.

49ers vs Cardinals Moneyline

The 49ers vs Cardinals moneyline has San Francisco as +190 road underdogs, while Arizona is the -230 favorite at home.

49ers vs Cardinals Betting Trends

- San Francisco is 11-5 straight up in its last 16 road games.
- The total has hit the under in four of San Francisco’s last six road games against Arizona.
- The total has hit the over in each of the last five home games for Arizona.
- Arizona is 5-1 straight up in its last six home games against San Francisco.

49ers vs Cardinals Odds

All betting lines, odds, and prop bets are available on FanDuel Sportsbook.
Moneyline: SF: (+190) | ARI: (-230)
Spread: SF: +5.5 (-112) | ARI: -5.5 (-108)
Total: 48.5 – Over: (-110) | Under: (-110)
Public (Spread) Betting Percentages via oddsFire: SF: (20%) | ARI: (80%)
Odds to Win Super Bowl LV: SF: (N/A) | ARI: (+5500)


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