Yankees vs Rays Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 22

Odds updated as of 6:11 p.m.

The Tuesday slate in MLB includes a matchup between the New York Yankees and the Tampa Bay Rays.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Yankees vs Rays Game Info

• New York Yankees (90-66) vs. Tampa Bay Rays (95-61)
• Date: Tuesday, September 22, 2026
• Time: 7:05 p.m. ET
• Venue: Yankee Stadium -- The Bronx, New York
• Coverage: TBS, YES, and Rays.TV

Yankees vs Rays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-144) | TB: (+122)
• Spread: NYY: -1.5 (+155) | TB: +1.5 (-188)
• Total: 6.5 -- Over: (-124) | Under: (+102)

Yankees vs Rays Probable Starting Pitchers

Probable Pitchers: Max Fried (Yankees) - 5-4, 2.63 ERA vs Drew Rasmussen (Rays) - 15-5, 2.72 ERA

The Yankees will look to Max Fried (5-4) versus the Rays and Drew Rasmussen (15-5). Fried and his team have a record of 10-7-0 against the spread when he starts. Fried's team has a record of 10-6 this season when he starts and they are the favorite on the moneyline. The Rays are 15-13-0 ATS in Rasmussen's 28 starts with a set spread. The Rays are 4-4 in Rasmussen's eight starts this season that they were the underdog on the moneyline.

Yankees vs Rays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (50.1%)

Yankees vs Rays Moneyline

• Looking at the moneyline for Rays-Yankees, Tampa Bay is the underdog at +122, and New York is -144 playing at home.

Yankees vs Rays Spread

• The Rays are at the Yankees, and are +1.5 on the runline. The Rays are +155 to cover the spread, and the Yankees are -188.

Yankees vs Rays Over/Under

• A total of 6.5 runs has been set for the Yankees-Rays game on Sept. 22, with the over available at -124 and the under at +102.

Bet on New York Yankees vs. Tampa Bay Rays on FanDuel today!

Yankees vs Rays Betting Trends

• The Yankees have been victorious in 72, or 60%, of the 120 contests they have been chosen as favorites in this season.
• This year New York has won 42 of 70 games when listed as at least -144 on the moneyline.
• The Yankees' games have gone over the total in 70 of their 151 opportunities.
• The Yankees are 78-73-0 against the spread in their 151 games that had a posted line this season.
• The Rays have been the moneyline underdog 45 total times this season. They've finished 24-21 in those games.
• In games it has played as a moneyline underdog with odds of +122 or longer, Tampa Bay has gone 8-3 (72.7%).
• The Rays have had an over/under set by oddsmakers 154 times, and have combined with opponents to go over the total in 71 of those games (71-81-2).
• The Rays have collected an 82-72-0 record ATS this season (covering 53.2% of the time).

Yankees Player Leaders

• Ben Rice leads New York with 145 hits and an OBP of .361, plus a team-best slugging percentage of .529. He's batting .262.
• Among all qualified hitters in baseball, he ranks 58th in batting average, 28th in on-base percentage, and third in slugging.
• Luis Garcia leads New York in total hits (141) this season while batting .279 with 61 extra-base hits. He's slugging .529 with an on-base percentage of .309.
• His batting average ranks 25th among qualified players, his on-base percentage 105th, and his slugging percentage third.
• Cody Bellinger is batting .270 with a .439 slugging percentage and 73 RBI this year.
• Bellinger brings a two-game hitting streak into this matchup. In his last five games he is hitting .273 with a home run, a walk and two RBIs.
• Jose Caballero has been key for New York with 95 hits, an OBP of .293 plus a slugging percentage of .371.

Rays Player Leaders

• Junior Caminero leads the Rays with 164 hits. He's batting .276 and slugging .526 with an on-base percentage of .362.
• He ranks 30th in batting average, 26th in on-base percentage and sixth in slugging percentage among all qualifying hitters in the majors.
• Yandy Diaz's .446 slugging percentage leads his team. He has a batting average of .290 with an on-base percentage of .356.
• He is currently 11th in batting average, 37th in on-base percentage and 48th in slugging percentage among all qualified hitters.
• Liam Hicks has put up an on-base percentage of .369, a team-best for the Rays.
• Chandler Simpson's .360 slugging percentage paces his team.

Yankees vs Rays Head to Head

• 9/22/2026: 2-0 NYY (Favorite: Yankees, Spread: -1.5, Total: 6.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 7/9/2026: 12-4 NYY (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 7/8/2026: 3-0 TB (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 7/7/2026: 6-4 TB (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/6/2026: 5-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/24/2026: 2-0 NYY (Favorite: Yankees, Spread: -1.5, Total: 7, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/22/2026: 4-2 TB (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 4/12/2026: 5-4 TB (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/11/2026: 5-4 TB (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 4/10/2026: 5-3 TB (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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