Yankees vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 4

Odds updated as of 9:12 p.m.

The San Diego Padres are among the MLB teams in action on Friday, up against the New York Yankees.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding this game.

Padres vs Yankees Game Info

• San Diego Padres (73-67) vs. New York Yankees (80-60)
• Date: Friday, September 4, 2026
• Time: 9:40 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and YES

Padres vs Yankees Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-116) | NYY: (-102)
• Spread: SD: +1.5 (-194) | NYY: -1.5 (+160)
• Total: 7.5 -- Over: (-124) | Under: (+102)

Padres vs Yankees Probable Starting Pitchers

Probable Pitchers: Walker Buehler (Padres) - 8-6, 4.66 ERA vs Max Fried (Yankees) - 4-4, 2.80 ERA

The probable pitchers are Walker Buehler (8-6) for the Padres and Max Fried (4-4) for the Yankees. Buehler's team is 20-7-0 against the spread this season in his starts. When Buehler starts a game and his team is the favorite on the moneyline, they have a record of 7-3. The Yankees have gone 8-6-0 against the spread when Fried starts. The Yankees were the underdog on the moneyline for one Fried start this season -- they lost.

Padres vs Yankees Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (57.1%)

Padres vs Yankees Moneyline

• New York is a -102 underdog on the moneyline, while San Diego is a -116 favorite at home.

Padres vs Yankees Spread

• The Yankees are 1.5-run favorites against the spread for this matchup with the Padres. The Yankees are +160 to cover, while the Padres are -194 to cover as a 1.5-run underdog on the runline.

Padres vs Yankees Over/Under

• The over/under for Padres-Yankees on Sept. 4 is 7.5. The over is -124, and the under is +102.

Bet on San Diego Padres vs. New York Yankees on FanDuel today!

Padres vs Yankees Betting Trends

• The Padres have been chosen as favorites in 63 games this year and have walked away with the win 35 times (55.6%) in those games.
• San Diego has a record of 32-23 when favored by -116 or more this year.
• The Padres and their opponents have hit the over in 62 of their 140 games with a total set by oddsmakers this season.
• The Padres are 81-59-0 against the spread in their 140 games with a line set by sportsbooks this season.
• The Yankees have been the moneyline underdog 25 total times this season. They've finished 13-12 in those games.
• When playing as a moneyline underdog with odds of -102 or longer, New York has a 13-8 record (winning 61.9% of its games).
• The Yankees have played in 135 games with an over/under set, and have combined with their opponents to go over the total 60 times (60-72-3).
• The Yankees have collected a 68-67-0 record against the spread this season (covering 50.4% of the time).

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego with 154 hits and an OBP of .350, plus a team-best slugging percentage of .449. He's batting .284.
• Among the qualified hitters in the majors, his batting average ranks 17th, his on-base percentage ranks 40th, and he is 45th in slugging.
• Tatis will look for his fourth straight game with a hit in this contest. During his last five outings he is batting .261 with a double, two home runs and three RBIs.
• Manny Machado is batting .219 with 21 doubles, 24 home runs and 66 walks. He's slugging .403 with an on-base percentage of .306.
• His batting average is 126th among qualified players, his on-base percentage 112th, and his slugging percentage 89th.
• Jackson Merrill has collected 128 base hits, an OBP of .293 and a slugging percentage of .418 this season.
• Xander Bogaerts has been key for San Diego with 99 hits, an OBP of .321 plus a slugging percentage of .323.

Yankees Player Leaders

• Ben Rice has 22 doubles, three triples, 35 home runs and 68 walks while batting .253. He's slugging .518 with an on-base percentage of .347.
• Including all the qualifying hitters in the big leagues, he ranks 73rd in batting average, 42nd in on-base percentage and eighth in slugging percentage.
• Luis Garcia has collected 129 hits while slugging .547. Both are team-highs. He has a batting average of .285 with an on-base percentage of .318.
• His batting average ranks 15th among all qualified players, his on-base percentage is 91st, and he is third in slugging.
• Cody Bellinger has accumulated a team-best .349 on-base percentage.
• Trent Grisham has 19 doubles, two triples, 18 home runs and 60 walks while hitting .211.

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