Yankees vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 4

Odds updated as of 6:13 a.m.

The MLB's Friday slate includes the New York Yankees facing the San Diego Padres.

All the information you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Yankees vs Padres Game Info

• New York Yankees (80-60) vs. San Diego Padres (73-67)
• Date: Friday, September 4, 2026
• Time: 9:40 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and YES

Yankees vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-132) | SD: (+112)
• Spread: NYY: -1.5 (+128) | SD: +1.5 (-154)
• Total: 7.5 -- Over: (-108) | Under: (-112)

Yankees vs Padres Probable Starting Pitchers

Probable Pitchers: Max Fried (Yankees) - 4-4, 2.80 ERA vs Walker Buehler (Padres) - 8-6, 4.66 ERA

The Yankees will call on Max Fried (4-4) against the Padres and Walker Buehler (8-6). When Fried starts, his team is 8-6-0 against the spread this season. Fried's team has a record of 8-5 this season when he starts and they are the favorite on the moneyline. The Padres have a 20-7-0 record against the spread in Buehler's starts. The Padres are 10-6 in Buehler's 16 starts this season that they were the underdog on the moneyline.

Yankees vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (50.1%)

Yankees vs Padres Moneyline

• New York is a -132 favorite on the moneyline, while San Diego is a +112 underdog at home.

Yankees vs Padres Spread

• The Padres are +1.5 on the spread (-154 to cover), and New York is +128 to cover the runline.

Yankees vs Padres Over/Under

• The over/under for Yankees-Padres on Sept. 4 is 7.5. The over is -108, and the under is -112.

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Yankees vs Padres Betting Trends

• The Yankees have been favorites in 108 games this season and have come away with the win 64 times (59.3%) in those contests.
• This season New York has been victorious 44 times in 77 chances when named as a favorite of at least -132 on the moneyline.
• Contests with the Yankees have gone over the total set by sportsbooks in 60 of 135 chances this season.
• The Yankees are 68-67-0 against the spread in their 135 games that had a posted line this season.
• The Padres are 34-38 in games they were listed as the moneyline underdog (winning 47.2% of those games).
• San Diego has a 15-23 record (winning only 39.5% of its games) when playing as a moneyline underdog of +112 or longer.
• The Padres have combined with opponents to hit the over on the total 62 times this season for a 62-76-2 record against the over/under.
• The Padres have gone 81-59-0 ATS this season.

Yankees Player Leaders

• Ben Rice has 22 doubles, three triples, 35 home runs and 68 walks while hitting .253. He has an on-base percentage of .347 and a slugging percentage of .518.
• Among all qualified hitters in MLB, he is 73rd in batting average, 42nd in on-base percentage, and eighth in slugging.
• Rice will look for his third straight game with a hit in this contest. During his last five outings he is hitting .217 with four RBIs.
• Luis Garcia has 129 hits to go with a slugging percentage of .547, both of which are tops among New York hitters this season. He's batting .285 with an on-base percentage of .318.
• His batting average is 15th among qualified players, his on-base percentage 91st, and his slugging percentage third.
• Cody Bellinger leads New York in OBP (.349) this season, fueled by 112 hits.
• Bellinger has recorded at least one base hit in six straight games. In his last 10 games he is batting .341 with a double, a home run, a walk and seven RBIs.
• Trent Grisham is batting .211 with a .307 OBP and 59 RBI for New York this season.
• Grisham brings a two-game hitting streak into this matchup. In his last five games he is hitting .111 with two walks and three RBIs.

Padres Player Leaders

• Fernando Tatis Jr. has a team-best OBP (.350) and slugging percentage (.449), while pacing the Padres in hits (154, while batting .284).
• Including all the qualifying hitters in MLB, he is 17th in batting average, 40th in on-base percentage and 45th in slugging percentage.
• Tatis hopes to build on a three-game hitting streak in this matchup. During his last five outings he is batting .261 with a double, two home runs and three RBIs.
• Manny Machado is hitting .219 with 21 doubles, 24 home runs and 66 walks. He's slugging .403 with an on-base percentage of .306.
• Including all qualified players, he is 126th in batting average, 112th in on-base percentage and 89th in slugging percentage.
• Jackson Merrill has 22 doubles, three triples, 22 home runs and 37 walks while batting .241.
• Ty France is hitting .292 with 17 doubles, two triples, 20 home runs and 31 walks.

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