Yankees vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 6:11 p.m.

The Baltimore Orioles versus the New York Yankees is on the MLB schedule for Friday.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Orioles vs Yankees Game Info

• Baltimore Orioles (78-81) vs. New York Yankees (92-67)
• Date: Friday, September 25, 2026
• Time: 7:05 p.m. ET
• Venue: Yankee Stadium -- The Bronx, New York
• Coverage: YES and MASN

Orioles vs Yankees Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-110) | NYY: (-106)
• Spread: BAL: -1.5 (+150) | NYY: +1.5 (-182)
• Total: 6.5 -- Over: (-132) | Under: (+108)

Orioles vs Yankees Probable Starting Pitchers

Probable Pitchers: Brandon Young (Orioles) - 9-5, 3.62 ERA vs TBA (Yankees)

Brandon Young (9-5) will take the mound for the Orioles in this matchup. The Yankees, however, have yet to list a starting pitcher. When Young starts, his team is 20-7-0 against the spread this season. When Young starts a game and his team is the favorite on the moneyline, they have a record of 8-4.

Orioles vs Yankees Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (61.5%)

Orioles vs Yankees Moneyline

• The Orioles vs Yankees moneyline has Baltimore as a -110 favorite, while New York is a -106 underdog at home.

Orioles vs Yankees Spread

• The Yankees are +1.5 on the run line against the Orioles. The Yankees are -182 to cover, and the Orioles are +150.

Orioles vs Yankees Over/Under

• The over/under for the Orioles versus Yankees game on Sept. 25 has been set at 6.5, with -132 odds on the over and +108 odds on the under.

Bet on Baltimore Orioles vs. New York Yankees on FanDuel today!

Orioles vs Yankees Betting Trends

• The Orioles have come away with 38 wins in the 70 contests they have been listed as the favorites in this season.
• Baltimore has a record of 36-30 when favored by -110 or more this year.
• Contests with the Orioles have gone over the total set by sportsbooks in 79 of 157 chances this season.
• The Orioles have an against the spread record of 83-74-0 in 157 games with a line this season.
• The Yankees have been the moneyline underdog 29 total times this season. They've gone 15-14 in those games.
• When playing as a moneyline underdog with odds of -106 or longer, New York has a 16-15 record (winning 51.6% of its games).
• In the 154 games bookmakers have set an over/under for the Yankees, they have combined with opponents to go over the total 73 times (73-77-4).
• The Yankees have an 80-74-0 record ATS this season (covering 51.9% of the time).

Orioles Player Leaders

• Pete Alonso has 157 hits and an OBP of .359 to go with a slugging percentage of .512. All three of those stats lead Baltimore hitters this season. He has a .264 batting average, as well.
• Among all qualified batters in MLB, he is 50th in batting average, 31st in on-base percentage, and 11th in slugging.
• Gunnar Henderson is batting .225 with 27 doubles, six triples, 24 home runs and 67 walks, while slugging .405 with an on-base percentage of .310.
• Among qualifying batters, he is 119th in batting average, 101st in on-base percentage and 85th in slugging percentage.
• Coby Mayo is batting .225 with a .463 slugging percentage and 63 RBI this year.
• Leody Taveras has eight home runs, 54 RBI and a batting average of .216 this season.

Yankees Player Leaders

• Ben Rice has racked up 148 hits with a .362 on-base percentage and a .535 slugging percentage, all club-bests for the Yankees. He's batting .262.
• Including all qualifying hitters in the big leagues, he ranks 54th in batting average, 26th in on-base percentage and third in slugging percentage.
• Luis Garcia is hitting .277 with 26 doubles, five triples, 30 home runs and 24 walks. He's slugging .522 with an on-base percentage of .308.
• Including all qualifying hitters, his batting average places him 29th, his on-base percentage is 106th, and he is fifth in slugging.
• Cody Bellinger is batting .266 with 25 doubles, three triples, 17 home runs and 59 walks.
• Jazz Chisholm is batting .233 with 16 doubles, three triples, 19 home runs and 56 walks.

Orioles vs Yankees Head to Head

• 8/20/2026: 6-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: +100)
• 8/19/2026: 5-3 NYY (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -104, Underdog Moneyline: -104)
• 8/18/2026: 3-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -106, Underdog Moneyline: -102)
• 5/13/2026: 7-0 BAL (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 5/12/2026: 6-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 5/11/2026: 3-2 BAL (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 5/4/2026: 12-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 5/3/2026: 11-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -295, Underdog Moneyline: +240)
• 5/2/2026: 9-4 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/1/2026: 7-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)

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