White Sox vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 4

Odds updated as of 7:12 p.m.

On Friday in MLB, the Chicago White Sox are playing the Minnesota Twins.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this matchup.

White Sox vs Twins Game Info

• Chicago White Sox (73-67) vs. Minnesota Twins (67-73)
• Date: Friday, September 4, 2026
• Time: 7:40 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and Twins.TV

White Sox vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHW: (-120) | MIN: (+102)
• Spread: CHW: +1.5 (-200) | MIN: -1.5 (+164)
• Total: 9 -- Over: (-114) | Under: (-106)

White Sox vs Twins Probable Starting Pitchers

Probable Pitchers: Erick Fedde (White Sox) - 7-8, 4.16 ERA vs Zebby Matthews (Twins) - 9-8, 4.58 ERA

The probable starters are Erick Fedde (7-8) for the White Sox and Zebby Matthews (9-8) for the Twins. Fedde and his team have a record of 9-4-0 against the spread when he starts. Fedde's team won his only start as a favorite this season. The Twins have gone 12-7-0 ATS in Matthews' 19 starts with a set spread. The Twins are 6-4 in Matthews' 10 starts this season that they were the underdog on the moneyline.

White Sox vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: White Sox win (50%)

White Sox vs Twins Moneyline

• Chicago is the favorite, -120 on the moneyline, while Minnesota is a +102 underdog on the road.

White Sox vs Twins Spread

• The Twins are 1.5-run favorites against the spread for this matchup with the White Sox. The Twins are +164 to cover, while the White Sox are -200 to cover as a 1.5-run underdog on the runline.

White Sox vs Twins Over/Under

• The over/under for White Sox-Twins on Sept. 4 is 9. The over is -114, and the under is -106.

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White Sox vs Twins Betting Trends

• The White Sox have been victorious in 17, or 58.6%, of the 29 contests they have been chosen as favorites in this season.
• This season Chicago has been victorious 13 times in 22 chances when named as a favorite of at least -120 on the moneyline.
• The White Sox and their opponents have gone over in 75 of their 137 games with a total set by sportsbooks this season.
• The White Sox have posted a record of 79-58-0 against the spread this season.
• The Twins have gone 36-45 in games they were listed as the moneyline underdog (winning 44.4% of those games).
• Minnesota is 31-39 (winning 44.3% of its games) when playing as a moneyline underdog of +102 or longer.
• The Twins have had an over/under set by bookmakers 137 times, and have combined with opponents to go over the total in 77 of those games (77-57-3).
• The Twins have put together a 74-63-0 record against the spread this season (covering 54% of the time).

White Sox Player Leaders

• Miguel Vargas leads Chicago in total hits (128) this season while batting .251 with 60 extra-base hits. He has an on-base percentage of .363 and a slugging percentage of .484.
• Among qualified hitters in baseball, he is 78th in batting average, 24th in on-base percentage, and 24th in slugging.
• Chase Meidroth has an OPS of .745, fueled by an OBP of .346 and a team-best slugging percentage of .400 this season. He's batting .273.
• He is 36th in batting average, 44th in on-base percentage and 93rd in slugging among qualifying hitters.
• Sam Antonacci leads Chicago with an OBP of .364 this season while batting .265 with 40 walks and 70 runs scored.
• Tristan Peters has 12 home runs, 52 RBI and a batting average of .278 this season.

Twins Player Leaders

• Brooks Lee has 21 doubles, three triples, 22 home runs and 33 walks while batting .250. He's slugging .435 with an on-base percentage of .299.
• Including all the qualified hitters in MLB, he is 82nd in batting average, 121st in on-base percentage and 58th in slugging percentage.
• Josh Bell is slugging .417 to lead his team. He has a batting average of .255 with an on-base percentage of .319.
• Including all qualified hitters, he ranks 66th in batting average, 90th in on-base percentage and 75th in slugging percentage.
• Kody Clemens is leading the Twins with 107 hits.
• Luke Keaschall has a .369 OBP to lead his team.

White Sox vs Twins Head to Head

• 8/30/2026: 5-1 MIN (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -114, Underdog Moneyline: +104)
• 8/29/2026: 3-2 CHW (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: +100)
• 8/28/2026: 7-4 CHW (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 6/3/2026: 8-0 CHW (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 6/2/2026: 6-4 MIN (Favorite: White Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/1/2026: 9-6 MIN (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 5/28/2026: 6-2 CHW (Favorite: White Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 5/27/2026: 15-2 CHW (Favorite: White Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 5/26/2026: 5-3 MIN (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/25/2026: 3-1 CHW (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)

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