White Sox vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 4

Odds updated as of 2:13 a.m.

In MLB action on Friday, the Chicago White Sox face the Minnesota Twins.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding this matchup.

White Sox vs Twins Game Info

• Chicago White Sox (73-67) vs. Minnesota Twins (67-73)
• Date: Friday, September 4, 2026
• Time: 7:40 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and Twins.TV

White Sox vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHW: (-120) | MIN: (+102)
• Spread: CHW: +1.5 (-205) | MIN: -1.5 (+168)
• Total: 9 -- Over: (-115) | Under: (-105)

White Sox vs Twins Probable Starting Pitchers

Probable Pitchers: Erick Fedde (White Sox) - 7-8, 4.16 ERA vs Zebby Matthews (Twins) - 9-8, 4.58 ERA

The White Sox will give the nod to Erick Fedde (7-8, 4.16 ERA), who is eyeing win No. 8 on the season, and the Twins will counter with Zebby Matthews (9-8, 4.58 ERA). Fedde's team is 9-4-0 against the spread in his starts this season. Fedde's team won his only start as a favorite this season. The Twins have a 12-7-0 ATS record in Matthews' 19 starts with a set spread. The Twins have been the moneyline underdog in 10 of Matthews' starts this season, and they went 6-4 in those games.

White Sox vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (51.5%)

White Sox vs Twins Moneyline

• Minnesota is the underdog, +102 on the moneyline, while Chicago is a -120 favorite at home.

White Sox vs Twins Spread

• The Twins are 1.5-run favorites against the spread for this matchup with the White Sox. The Twins are +168 to cover, while the White Sox are -205 to cover as a 1.5-run underdog on the runline.

White Sox vs Twins Over/Under

• The over/under for the White Sox versus Twins contest on Sept. 4 has been set at 9, with -115 odds on the over and -105 odds on the under.

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White Sox vs Twins Betting Trends

• The White Sox have won in 17, or 58.6%, of the 29 contests they have been named as odds-on favorites in this year.
• Chicago has a record of 13-9 when favored by -120 or more this year.
• Contests with the White Sox have gone over the total set by sportsbooks in 75 of 137 chances this season.
• The White Sox are 79-58-0 against the spread in their 137 games with a line set by sportsbooks this season.
• The Twins have been the underdog on the moneyline 81 total times this season. They've finished 36-45 in those games.
• In games it has played as a moneyline underdog with odds of +102 or longer, Minnesota has a record of 31-39 (44.3%).
• The Twins have played in 137 games with an over/under set, and have combined with opponents to go over the total 77 times (77-57-3).
• The Twins have covered 54% of their games this season, going 74-63-0 ATS.

White Sox Player Leaders

• Miguel Vargas leads Chicago in total hits (128) this season while batting .251 with 60 extra-base hits. He has an on-base percentage of .363 and a slugging percentage of .484.
• Among qualified batters in MLB, his batting average ranks 78th, his on-base percentage ranks 23rd, and he is 24th in slugging.
• Chase Meidroth has an OPS of .745, fueled by an OBP of .346 and a team-best slugging percentage of .400 this season. He's batting .273.
• Among all qualified, he ranks 37th in batting average, 45th in on-base percentage and 93rd in slugging percentage.
• Sam Antonacci has 109 hits this season and a team-best OBP of .364.
• Tristan Peters has been key for Chicago with 105 hits, an OBP of .344 plus a slugging percentage of .466.

Twins Player Leaders

• Brooks Lee is batting .250 with 21 doubles, three triples, 22 home runs and 33 walks. He's slugging .435 with an on-base percentage of .299.
• Including all the qualified players in the majors, he ranks 82nd in batting average, 121st in on-base percentage and 58th in slugging percentage.
• Josh Bell is slugging .417 to lead his team. He has a batting average of .255 with an on-base percentage of .319.
• Including all qualifying players, he ranks 66th in batting average, 90th in on-base percentage and 76th in slugging percentage.
• Luke Keaschall has put up an on-base percentage of .369, a team-best for the Twins.
• Kody Clemens' 107 hits pace his team.

White Sox vs Twins Head to Head

• 8/30/2026: 5-1 MIN (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -114, Underdog Moneyline: +104)
• 8/29/2026: 3-2 CHW (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: +100)
• 8/28/2026: 7-4 CHW (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 6/3/2026: 8-0 CHW (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 6/2/2026: 6-4 MIN (Favorite: White Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/1/2026: 9-6 MIN (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 5/28/2026: 6-2 CHW (Favorite: White Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 5/27/2026: 15-2 CHW (Favorite: White Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 5/26/2026: 5-3 MIN (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/25/2026: 3-1 CHW (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)

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