White Sox vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 8

Odds updated as of 7:12 p.m.

MLB action on Tuesday includes the Chicago White Sox taking on the Pittsburgh Pirates.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this game.

White Sox vs Pirates Game Info

• Chicago White Sox (75-68) vs. Pittsburgh Pirates (71-73)
• Date: Tuesday, September 8, 2026
• Time: 7:40 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and SportsNet PT

White Sox vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHW: (-146) | PIT: (+124)
• Spread: CHW: -1.5 (+146) | PIT: +1.5 (-178)
• Total: 8.5 -- Over: (-106) | Under: (-114)

White Sox vs Pirates Probable Starting Pitchers

Probable Pitchers: Sean Burke (White Sox) - 8-6, 3.20 ERA vs Bubba Chandler (Pirates) - 6-9, 4.30 ERA

The probable starters are Sean Burke (8-6) for the White Sox and Bubba Chandler (6-9) for the Pirates. Burke and his team are 13-11-0 ATS this season when he starts. Burke's team has won 77.8% of his starts when they are favored on the moneyline (7-2). The Pirates have a 14-12-0 ATS record in Chandler's 26 starts that had a set spread. The Pirates have a 6-10 record in Chandler's 16 starts this season when they were the moneyline underdog.

White Sox vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (50.6%)

White Sox vs Pirates Moneyline

• Chicago is the favorite, -146 on the moneyline, while Pittsburgh is a +124 underdog on the road.

White Sox vs Pirates Spread

• The White Sox are hosting the Pirates and are favored by 1.5 runs (+146 to cover) on the runline. Pittsburgh is -178 to cover.

White Sox vs Pirates Over/Under

• A combined run total of 8.5 has been set for White Sox-Pirates on Sept. 8, with the over at -106 and the under at -114.

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White Sox vs Pirates Betting Trends

• The White Sox have been victorious in 19, or 59.4%, of the 32 contests they have been chosen as favorites in this season.
• This season Chicago has come away with a win four times in five chances when named as a favorite of at least -146 on the moneyline.
• The White Sox's games have gone over the total in 77 of their 140 opportunities.
• The White Sox are 81-59-0 against the spread in their 140 games that had a posted line this season.
• The Pirates have won 27 of the 64 games they were listed as the moneyline underdog this season (42.2%).
• In games it has played as a moneyline underdog with odds of +124 or longer, Pittsburgh has a 6-13 record (winning just 31.6% of its games).
• The Pirates have had an over/under set by bookmakers 142 times, and have combined with opponents to go over the total in 74 of those games (74-64-4).
• The Pirates have put together a 67-75-0 record against the spread this season.

White Sox Player Leaders

• Miguel Vargas has 132 hits, which ranks first among Chicago hitters this season, while batting .252 with 61 extra-base hits. He has an on-base percentage of .363 and a slugging percentage of .486.
• Among all qualifying batters in the majors, his batting average ranks 74th, his on-base percentage ranks 25th, and he is 22nd in slugging.
• Vargas will look for his fifth straight game with a hit in this matchup. In his last five games he is batting .286 with a home run, a walk and three RBIs.
• Sam Antonacci has 113 hits this season and a team-best OBP of .367. He's batting .268 and slugging .393.
• Among all qualifying hitters, he is 46th in batting average, 22nd in on-base percentage and 99th in slugging percentage.
• Tristan Peters has 111 hits this season and has a slash line of .285/.348/.474.
• Peters has recorded at least one base hit in three straight games. In his last five games he is hitting .471 with three doubles, a triple and an RBI.
• Chase Meidroth has an OPS of .740, fueled by an OBP of .346 and a team-best slugging percentage of .394 this season.

Pirates Player Leaders

• Bryan Reynolds a has .373 on-base percentage to lead the Pirates. He's batting .266 while slugging .428.
• Including all qualifying hitters, he is 51st in batting average, while his on-base percentage is 12th and he is 62nd in slugging.
• Brandon Lowe paces his team with 134 hits. He has a batting average of .256 while slugging .479 with an on-base percentage of .324.
• He ranks 68th in batting average, 80th in on-base percentage and 25th in slugging percentage in MLB.
• Nick Gonzales has racked up a team-high .393 slugging percentage.
• Oneil Cruz has 11 doubles, a triple, 17 home runs and 41 walks while hitting .265.

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