White Sox vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for May 23

Odds updated as of 3:12 p.m.

MLB action on Saturday includes the Chicago White Sox facing the San Francisco Giants.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

White Sox vs Giants Game Info

• Chicago White Sox (26-24) vs. San Francisco Giants (20-31)
• Date: Saturday, May 23, 2026
• Time: 4:05 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and CHSN

White Sox vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHW: (-112) | SF: (-104)
• Spread: CHW: -1.5 (+152) | SF: +1.5 (-184)
• Total: 7.5 -- Over: (+100) | Under: (-122)

White Sox vs Giants Probable Starting Pitchers

Probable Pitchers: Bryan Hudson (White Sox) - 2-1, 1.57 ERA vs Adrian Houser (Giants) - 2-4, 5.25 ERA

The White Sox will call on Bryan Hudson (2-1) versus the Giants and Adrian Houser (2-4). Hudson has a record of 2-0-0 ATS in two starts with a spread this season. Hudson's team is 1-1 this season when he starts and they're favored on the moneyline. The Giants have a 3-6-0 record against the spread in Houser's starts. The Giants have been the underdog on the moneyline in eight of Houser's starts this season, and they went 2-6 in those matchups.

White Sox vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (52.3%)

White Sox vs Giants Moneyline

• Chicago is a -112 favorite on the moneyline, while San Francisco is a -104 underdog at home.

White Sox vs Giants Spread

• The Giants are hosting the White Sox, and are +1.5 on the runline. The Giants are +152 to cover the spread, and the White Sox are -184.

White Sox vs Giants Over/Under

• The over/under for White Sox-Giants on May 23 is 7.5. The over is +100, and the under is -122.

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White Sox vs Giants Betting Trends

• The White Sox have been chosen as favorites in five games this year and have walked away with the win two times (40%) in those games.
• Chicago has a record of 2-3 when favored by -112 or more this year.
• The White Sox and their opponents have gone over in 27 of their 48 games with a total set by sportsbooks this season.
• The White Sox have an against the spread mark of 29-19-0 in 48 games with a line this season.
• The Giants have won 13 of the 37 games they were listed as the moneyline underdog this season (35.1%).
• San Francisco has gone 13-19 in games it has played as a moneyline underdog with odds of -104 or longer (40.6%).
• The Giants have played in 51 games with an over/under set, and have combined with their opponents to go over the total 23 times (23-25-3).
• The Giants have put together a 20-31-0 record ATS this season (covering just 39.2% of the time).

White Sox Player Leaders

• Miguel Vargas is batting .237 with seven doubles, a triple, 11 home runs and 32 walks. He has an on-base percentage of .368 while slugging .480.
• He ranks 110th in batting average, 30th in on-base percentage, and 36th in slugging among qualified hitters in baseball.
• Munetaka Murakami has 43 hits and an OBP of .387, both of which lead the White Sox this season. He's batting .246 and slugging .554.
• He is 91st in batting average, 16th in on-base percentage and 10th in slugging in the majors.
• Murakami has picked up at least one hit in two straight games. During his last five outings he is hitting .333 with two doubles, four walks and four RBIs.
• Colson Montgomery has 40 hits this season and has a slash line of .222/.320/.483.
• Chase Meidroth has an OPS of .707, fueled by an OBP of .342 and a team-best slugging percentage of .366 this season.

Giants Player Leaders

• Luis Arraez has accumulated a .359 on-base percentage and a .421 slugging percentage, both team-best numbers for the Giants. He's batting .321.
• Including all qualified hitters in MLB, he is fifth in batting average, 42nd in on-base percentage and 77th in slugging percentage.
• Arraez hopes to build on a three-game hitting streak in this matchup. During his last five outings he is hitting .350 with a home run, a walk and three RBIs.
• Casey Schmitt has collected 46 hits to pace his team. He has a batting average of .286 while slugging .516 with an on-base percentage of .329.
• Including all qualifying hitters, he ranks 32nd in batting average, 81st in on-base percentage and 19th in slugging percentage.
• Rafael Devers is hitting .241 with 12 doubles, six home runs and 13 walks.
• Matt Chapman is batting .228 with 12 doubles, a triple, a home run and 19 walks.

White Sox vs Giants Head to Head

• 5/22/2026: 9-4 CHW (Favorite: White Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/29/2025: 5-2 CHW (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 6/28/2025: 1-0 CHW (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 6/27/2025: 3-1 SF (Favorite: Giants, Spread: -1.5, Total: 9, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/21/2024: 6-2 CHW (Favorite: Giants, Spread: -1.5, Total: 6.5, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 8/20/2024: 4-1 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -255, Underdog Moneyline: +210)
• 8/19/2024: 5-3 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 4/6/2023: 16-6 SF (Favorite: White Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/5/2023: 7-3 CHW (Favorite: White Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/3/2023: 12-3 SF (Favorite: White Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)

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