White Sox vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 1

Odds updated as of 7:12 p.m.

The Chicago White Sox are among the MLB squads busy on Tuesday, up against the Houston Astros.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

White Sox vs Astros Game Info

• Chicago White Sox (72-65) vs. Houston Astros (70-68)
• Date: Tuesday, September 1, 2026
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and CHSN

White Sox vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHW: (-112) | HOU: (-104)
• Spread: CHW: -1.5 (+140) | HOU: +1.5 (-170)
• Total: 8.5 -- Over: (-110) | Under: (-110)

White Sox vs Astros Probable Starting Pitchers

Probable Pitchers: Sean Burke (White Sox) - 7-6, 3.32 ERA vs Ronel Blanco (Astros) - 0-1, 7.71 ERA

This contest's pitching matchup is set, as the White Sox will send Sean Burke (7-6) to the mound, while Ronel Blanco (0-1) will get the nod for the Astros. Burke and his team are 12-11-0 ATS this season when he starts. Burke's team is 6-2 this season when he starts and they are the moneyline favorite. The Astros have a 3-1-0 record against the spread in Blanco's starts. The Astros have been the moneyline underdog in three of Blanco's starts this season, and they went 2-1 in those games.

White Sox vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: White Sox win (53.4%)

White Sox vs Astros Moneyline

• Looking at the moneyline for Astros-White Sox, Houston is the underdog at -104, and Chicago is -112 playing on the road.

White Sox vs Astros Spread

• The White Sox are 1.5-run road favorites on the runline against the Astros. The White Sox are +140 to cover, and the Astros are -170.

White Sox vs Astros Over/Under

• White Sox versus Astros on Sept. 1 has an over/under of 8.5 runs, with the odds on the over -110 and the under set at -110.

Bet on Chicago White Sox vs. Houston Astros on FanDuel today!

White Sox vs Astros Betting Trends

• The White Sox have been chosen as favorites in 28 games this year and have walked away with the win 16 times (57.1%) in those games.
• This season Chicago has come away with a win 15 times in 26 chances when named as a favorite of at least -112 on the moneyline.
• The White Sox and their opponents have gone over the total this season in 75 of their 134 opportunities.
• The White Sox are 78-56-0 against the spread in their 134 games with a line set by sportsbooks this season.
• The Astros have put together a 38-35 record in games they were listed as the moneyline underdog (winning 52.1% of those games).
• Houston has a 35-30 record (winning 53.8% of its games) when it has played as a moneyline underdog of -104 or longer.
• The Astros have played in 138 games with a set over/under, and have combined with their opponents to go over the total 72 times (72-59-7).
• The Astros have covered 48.6% of their games this season, going 67-71-0 against the spread.

White Sox Player Leaders

• Miguel Vargas has 30 doubles, a triple, 29 home runs and 85 walks while hitting .249. He has an on-base percentage of .363 and a slugging percentage of .488.
• Among qualifying hitters in the majors, he ranks 83rd in batting average, 26th in on-base percentage, and 24th in slugging.
• Vargas hopes to build on a two-game hitting streak in this matchup. During his last five outings he is batting .278 with five walks and an RBI.
• Chase Meidroth has an OPS of .744, fueled by an OBP of .346 and a team-best slugging percentage of .398 this season. He's batting .271.
• He is 43rd in batting average, 48th in on-base percentage and 94th in slugging in the major leagues.
• Sam Antonacci has 108 hits this season and a team-best OBP of .366.
• Antonacci heads into this matchup with two games in a row with at least one hit. During his last five outings he is hitting .294 with a double, three walks and two RBIs.
• Tristan Peters is batting .278 with a .344 OBP and 52 RBI for Chicago this season.

Astros Player Leaders

• Yordan Alvarez has totaled 155 hits with a .432 on-base percentage and a .605 slugging percentage, all club-bests for the Astros. He's batting .317.
• He is first in batting average, first in on-base percentage and first in slugging percentage among all qualified batters in the majors.
• Isaac Paredes has 23 doubles, a triple, 17 home runs and 59 walks while hitting .256. He's slugging .416 with an on-base percentage of .355.
• Including all qualifying hitters, he is 66th in batting average, 37th in on-base percentage and 77th in slugging percentage.
• Christian Walker is batting .229 with 25 doubles, a triple, 24 home runs and 44 walks.
• Jeremy Pena has 16 doubles, a triple, 17 home runs and 22 walks while hitting .284.

White Sox vs Astros Head to Head

• 8/31/2026: 6-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +118)
• 7/26/2026: 12-3 CHW (Favorite: White Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/25/2026: 4-1 HOU (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/24/2026: 9-5 HOU (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/12/2025: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -275, Underdog Moneyline: +225)
• 6/11/2025: 10-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/10/2025: 4-2 CHW (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 5/4/2025: 5-4 CHW (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/3/2025: 8-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 5/2/2025: 7-3 CHW (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -240, Underdog Moneyline: +198)

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