USC vs UCLA Prediction, Odds, Picks, Best Bets for Week 14 2025

In college football action on Saturday, the USC Trojans take on the UCLA Bruins.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding today's NCAA football betting odds.

USC vs UCLA Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: USC: (-2222) | UCLA: (+1100)
• Spread: USC: -21.5 (-110) | UCLA: +21.5 (-110)
• Total: 58.5 -- Over: (-115) | Under: (-105)

USC vs UCLA Betting Trends

• USC's record against the spread is 5-6-0.
• USC is unbeaten ATS (2-0) as a 21.5-point favorite or greater this season.
• Out of 11 USC games so far this year, six have gone over the total.
• Against the spread, UCLA is 3-8-0 this season.
• UCLA has one win ATS (1-2) as a 21.5-point underdog or greater this year.
• Of 11 UCLA games so far this season, six have hit the over.

USC vs UCLA Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Trojans win (95.6%)

USC vs UCLA Point Spread

USC is favored by 21.5 points over UCLA. USC is -110 to cover the spread, with UCLA being -110.

USC vs UCLA Over/Under

The USC-UCLA game on Nov. 29 has been given an over/under of 58.5 points. The over is -115 and the under is -105.

USC vs UCLA Moneyline

Looking at the moneyline for USC-UCLA, USC is the favorite at -2222, and UCLA is +1100.

USC vs. UCLA Points Insights

USC vs. UCLA Game Info

• Game day: Saturday, November 29, 2025
• Game time: 7:30 p.m. ET
• TV channel: NBC
• Location: Los Angeles, California
• Stadium: Los Angeles Memorial Coliseum

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth USC vs. UCLA analysis on FanDuel Research.