USC vs Fresno State Prediction, Odds, Picks, Best Bets for Week 1 2026

The college football slate on Friday includes the USC Trojans facing the Fresno State Bulldogs.

Get the latest NCAA football odds ahead of this game on FanDuel Sportsbook.

USC vs Fresno State Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: USC: (-2778) | Fresno State: (+1160)
• Spread: USC: -21.5 (-110) | Fresno State: +21.5 (-110)
• Total: 51.5 -- Over: (-115) | Under: (-105)

USC vs Fresno State Betting Trends

• USC's record against the spread last year was 5-8-0.
• As a 21.5-point or greater favorite last season, USC had two wins against the spread (2-1).
• In 13 USC games last year, seven went over the total.
• Against the spread, Fresno State was 7-6-0 last year.
• In 13 Fresno State games last season, five of them went over the total.

USC vs Fresno State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Trojans win (93.3%)

USC vs Fresno State Point Spread

Fresno State is listed as an underdog by 21.5 points (-110 odds), and USC, the favorite, is -110 to cover.

USC vs Fresno State Over/Under

The over/under for USC-Fresno State on Sept. 4 is 51.5. The over is -115, and the under is -105.

USC vs Fresno State Moneyline

USC is the favorite, -2778 on the moneyline, while Fresno State is a +1160 underdog.

USC vs. Fresno State Points Insights

• The Trojans had an average implied point total of 36.2 last season, which is 0.8 points lower than their implied total in Friday's game (37).
• The average implied point total last season for the Bulldogs (27.9) is 12.9 more points than the team's implied total in this matchup (15).

USC vs. Fresno State Game Info

• Game day: Friday, September 4, 2026
• Game time: 9 p.m. ET
• TV channel: FOX
• Location: Los Angeles, California
• Stadium: Los Angeles Memorial Coliseum

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