Tulane vs Southern Miss Prediction, Odds, Picks, Best Bets for Week 4 2026

The Saturday schedule in college football includes a matchup between the Tulane Green Wave and the Southern Miss Golden Eagles.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital info about today's NCAA football betting odds.

Tulane vs Southern Miss Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Tulane: (-1099) | Southern Miss: (+680)
• Spread: Tulane: -18.5 (-108) | Southern Miss: +18.5 (-112)
• Total: 52.5 -- Over: (-110) | Under: (-110)

Tulane vs Southern Miss Betting Trends

• Tulane hasn won once against the spread this year.
• Two of three Tulane games have gone over the point total this season.
• Southern Miss has but one win versus the spread this season.
• Southern Miss doesn't have a win ATS (0-1) as an 18.5-point underdog or greater this year.
• Southern Miss has played two games (out of three) which finished over the total this season.

Tulane vs Southern Miss Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Green Wave win (83.3%)

Tulane vs Southern Miss Point Spread

Southern Miss is listed as an underdog by 18.5 points (-112 odds), and Tulane, the favorite, is -108 to cover.

Tulane vs Southern Miss Over/Under

The over/under for the Tulane versus Southern Miss matchup on Sept. 26 has been set at 52.5, with -110 odds on the over and -110 odds on the under.

Tulane vs Southern Miss Moneyline

The moneyline numbers for Tulane vs. Southern Miss reveal Tulane as the favorite (-1099) and Southern Miss as the underdog (+680).

Tulane vs. Southern Miss Points Insights

Tulane vs. Southern Miss Game Info

• Game day: Saturday, September 26, 2026
• Game time: 7 p.m. ET
• TV channel: ESPN+
• Location: New Orleans, Louisiana
• Stadium: Yulman Stadium

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Check out even more in-depth Tulane vs. Southern Miss analysis on FanDuel Research.