South Carolina vs Mississippi State Prediction, Odds, Picks, Best Bets for Week 3 2026

The South Carolina Gamecocks are among the college football squads in action on Saturday, versus the Mississippi State Bulldogs.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding today's NCAA football betting odds.

South Carolina vs Mississippi State Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: South Carolina: (-162) | Mississippi State: (+134)
• Spread: South Carolina: -3.5 (-105) | Mississippi State: +3.5 (-115)
• Total: 58.5 -- Over: (-115) | Under: (-105)

South Carolina vs Mississippi State Betting Trends

• South Carolina has one win against the spread this season.
• As a 3.5-point or greater favorite, South Carolina has one win ATS (1-1) this season.
• South Carolina has had one game (of two) go over the total this season.
• Mississippi State owns two wins against the spread this season.
• Mississippi State has had one game (of two) hit the over this year.

South Carolina vs Mississippi State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Gamecocks win (63.4%)

South Carolina vs Mississippi State Point Spread

South Carolina is favored by 3.5 points (-105 to cover) in this matchup. Mississippi State, the underdog, is -115.

South Carolina vs Mississippi State Over/Under

The over/under for the South Carolina versus Mississippi State matchup on Sept. 19 has been set at 58.5, with -115 odds on the over and -105 odds on the under.

South Carolina vs Mississippi State Moneyline

South Carolina is a -162 favorite on the moneyline, while Mississippi State is a +134 underdog.

South Carolina vs. Mississippi State Points Insights

South Carolina vs. Mississippi State Game Info

• Game day: Saturday, September 19, 2026
• Game time: 4:15 p.m. ET
• TV channel: SEC Network
• Location: Columbia, South Carolina
• Stadium: Williams-Brice Stadium

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Check out even more in-depth South Carolina vs. Mississippi State analysis on FanDuel Research.