South Carolina vs Clemson Prediction, Odds, Picks, Best Bets for Week 14 2025

College football's Saturday slate includes the South Carolina Gamecocks facing the Clemson Tigers.

Get the latest NCAA football odds ahead of this matchup on FanDuel Sportsbook.

South Carolina vs Clemson Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: South Carolina: (-134) | Clemson: (+114)
• Spread: South Carolina: -2.5 (-115) | Clemson: +2.5 (-105)
• Total: 47.5 -- Over: (-105) | Under: (-115)

South Carolina vs Clemson Betting Trends

• South Carolina's record against the spread is 6-5-0.
• As 2.5-point favorites or more, South Carolina is 3-2 against the spread.
• This season, five of South Carolina's 11 games have hit the over.
• Clemson has covered the spread four times in 11 games.
• Clemson has covered every time (1-0) as a 2.5-point or greater underdog this season.
• There have been five Clemson games (out of 11) that went over the total this season.

South Carolina vs Clemson Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Gamecocks win (64.2%)

South Carolina vs Clemson Point Spread

South Carolina is favored by 2.5 points over Clemson. South Carolina is -115 to cover the spread, with Clemson being -105.

South Carolina vs Clemson Over/Under

South Carolina versus Clemson on Nov. 29 has an over/under of 47.5 points, with the over -105 and the under -115.

South Carolina vs Clemson Moneyline

The South Carolina vs Clemson moneyline has South Carolina as a -134 favorite, while Clemson is a +114 underdog.

South Carolina vs. Clemson Points Insights

South Carolina vs. Clemson Game Info

• Game day: Saturday, November 29, 2025
• Game time: 12 p.m. ET
• TV channel: SEC Network
• Location: Columbia, South Carolina
• Stadium: Williams-Brice Stadium

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth South Carolina vs. Clemson analysis on FanDuel Research.