San Jose State vs USC Prediction, College Football Picks, Odds & Best Bets Today 8/29/26

College Football Betting Picks in Summary

• USC -38.5
• Over 61.5
• Jayden Maiava 3+ Passing Touchdowns

San Jose State travels to USC today in one of the most lopsided lines on the entire college football board — a spread nearing 40 points that leaves very little room for debate about who's favored.

All college football odds come from FanDuel Sportsbook's college football betting odds and may change after this article is published.

College Football Predictions and Picks

San Jose State at USC

USC -38.5 (-108)

USC's own alt-total yardage market pricing a 542.5-yard team total at even odds tells the story here — this is a genuine talent gap the market has priced with real conviction, not a number worth fading.

Over 61.5 (-110)

A near-40-point spread paired with a total over 60 tells you the market expects USC to produce even while winning comfortably, not a defensive stalemate that just happens to be lopsided.

Jayden Maiava 3+ Passing Touchdowns (-144)

Maiava's own line sits near 285 passing yards, and with a receiving corps this deep sharing the workload, three touchdown passes is a very reasonable ask in a game USC is expected to control from the opening drive.