Phillies vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 22

Odds updated as of 12:12 a.m.

The Philadelphia Phillies are among the MLB teams busy on Saturday, versus the St. Louis Cardinals.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Phillies vs Cardinals Game Info

• Philadelphia Phillies (71-58) vs. St. Louis Cardinals (66-64)
• Date: Saturday, August 22, 2026
• Time: 6:05 p.m. ET
• Venue: Citizens Bank Park -- Philadelphia, Pennsylvania
• Coverage: NBCS-PH and Cardinals.TV

Phillies vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PHI: (-132) | STL: (+112)
• Spread: PHI: -1.5 (+164) | STL: +1.5 (-200)
• Total: 8.5 -- Over: (-115) | Under: (-105)

Phillies vs Cardinals Probable Starting Pitchers

Probable Pitchers: Andrew Painter (Phillies) - 2-8, 6.43 ERA vs Quinn Mathews (Cardinals) - 0-1, 3.00 ERA

This contest's pitching matchup is set, as the Phillies will send Andrew Painter (2-8) to the mound, while Quinn Mathews (0-1) will get the nod for the Cardinals. Painter's team is 2-14-0 against the spread in his starts this season. Painter's team has won 55.6% of his starts when they are favored on the moneyline (5-4). Mathews has started two games with set spreads, and the Cardinals failed to cover in both chances. The Cardinals were the moneyline underdog for one Mathews start this season -- they lost.

Phillies vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (53.2%)

Phillies vs Cardinals Moneyline

• St. Louis is the underdog, +112 on the moneyline, while Philadelphia is a -132 favorite at home.

Phillies vs Cardinals Spread

• The Cardinals are +1.5 on the spread (-200 to cover), and Philadelphia is +164 to cover the runline.

Phillies vs Cardinals Over/Under

• A total of 8.5 runs has been set for the Phillies-Cardinals game on Aug. 22, with the over available at -115 and the under at -105.

Bet on Philadelphia Phillies vs. St. Louis Cardinals on FanDuel today!

Phillies vs Cardinals Betting Trends

• The Phillies have been chosen as favorites in 93 games this year and have walked away with the win 60 times (64.5%) in those games.
• This season Philadelphia has come away with a win 51 times in 75 chances when named as a favorite of at least -132 on the moneyline.
• The Phillies and their opponents have gone over in 58 of their 125 games with a total set by sportsbooks this season.
• In 125 games with a line this season, the Phillies have a mark of 50-75-0 against the spread.
• The Cardinals have gone 40-45 in games they were listed as the moneyline underdog (winning 47.1% of those games).
• St. Louis has a record of 24-27 when it has played as a moneyline underdog with odds of +112 or longer (47.1%).
• The Cardinals have played in 126 games with an over/under set, and have combined with opponents to go over the total 52 times (52-67-7).
• The Cardinals are 68-58-0 against the spread this season.

Phillies Player Leaders

• Bryce Harper leads Philadelphia with an OBP of .379 this season while batting .257 with 92 walks and 81 runs scored. He has a slugging percentage of .488.
• Among all qualifying hitters in the majors, he is 72nd in batting average, 10th in on-base percentage, and 23rd in slugging.
• Luis Arraez has hit six homers this season while driving in 54 runs. He's batting .322 this season and slugging .444 with an on-base percentage of .355.
• Among qualifying batters, his batting average ranks him first, his on-base percentage 39th, and his slugging percentage 52nd.
• Arraez has picked up at least one hit in eight games in a row. In his last 10 games he is hitting .341 with three doubles, a home run, a walk and six RBIs.
• Bryson Stott has collected 112 base hits, an OBP of .340 and a slugging percentage of .411 this season.
• Kyle Schwarber leads Philadelphia in total hits (111) this season while batting .242 with 53 extra-base hits.

Cardinals Player Leaders

• Alec Burleson has 33 doubles, a triple, 21 home runs and 46 walks while hitting .289. He's slugging .489 with an on-base percentage of .355.
• Including all qualifying hitters in MLB, he is 16th in batting average, 39th in on-base percentage and 22nd in slugging percentage.
• Burleson hopes to build on an eight-game hitting streak in this matchup. During his last 10 outings he is hitting .342 with four doubles, two home runs, two walks and 12 RBIs.
• Jordan Walker's 143 hits and .513 slugging percentage both pace his team. He has a batting average of .291 with an on-base percentage of .350.
• He is currently 13th in batting average, 46th in on-base percentage and 14th in slugging percentage among all qualifying hitters.
• JJ Wetherholt is hitting .241 with 14 doubles, 16 home runs and 62 walks.
• Ivan Herrera's .360 on-base percentage paces his team.

Phillies vs Cardinals Head to Head

• 8/21/2026: 7-6 PHI (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -260, Underdog Moneyline: +235)
• 8/12/2026: 7-1 STL (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -164, Underdog Moneyline: +150)
• 8/11/2026: 2-0 STL (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +142)
• 8/10/2026: 6-5 PHI (Favorite: Phillies, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: +108)
• 5/14/2025: 14-7 STL (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/14/2025: 2-1 PHI (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 5/12/2025: 3-2 STL (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 4/13/2025: 7-0 STL (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/12/2025: 4-1 PHI (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 4/11/2025: 2-0 STL (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)

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