Phillies vs Brewers Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 22

Odds updated as of 6:11 p.m.

In MLB action on Tuesday, the Philadelphia Phillies play the Milwaukee Brewers.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Phillies vs Brewers Game Info

• Philadelphia Phillies (86-70) vs. Milwaukee Brewers (98-58)
• Date: Tuesday, September 22, 2026
• Time: 6:40 p.m. ET
• Venue: Citizens Bank Park -- Philadelphia, Pennsylvania
• Coverage: NBCS-PH and Brewers.TV

Phillies vs Brewers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PHI: (-142) | MIL: (+120)
• Spread: PHI: -1.5 (+152) | MIL: +1.5 (-184)
• Total: 7.5 -- Over: (+104) | Under: (-128)

Phillies vs Brewers Probable Starting Pitchers

Probable Pitchers: Zack Wheeler (Phillies) - 13-5, 2.99 ERA vs Dustin May (Brewers) - 7-9, 4.61 ERA

This contest's pitching matchup is set, as the Phillies will send Zack Wheeler (13-5) to the mound, while Dustin May (7-9) will take the ball for the Brewers. Wheeler's team is 14-9-0 against the spread this season in his starts. Wheeler's team has won 77.8% of his starts when they are favored on the moneyline (14-4). The Brewers have a 14-15-0 ATS record in May's 29 starts that had a set spread. The Brewers have been the moneyline underdog in 14 of May's starts this season, and they went 5-9 in those games.

Phillies vs Brewers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (50.6%)

Phillies vs Brewers Moneyline

• The Phillies vs Brewers moneyline has Philadelphia as a -142 favorite, while Milwaukee is a +120 underdog on the road.

Phillies vs Brewers Spread

• The Brewers are +1.5 on the run line against the Phillies. The Brewers are -184 to cover, and the Phillies are +152.

Phillies vs Brewers Over/Under

• A total of 7.5 runs has been set for the Phillies-Brewers game on Sept. 22, with the over available at +104 and the under at -128.

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Phillies vs Brewers Betting Trends

• The Phillies have won in 73, or 64.6%, of the 113 contests they have been named as odds-on favorites in this year.
• This season Philadelphia has come away with a win 58 times in 77 chances when named as a favorite of at least -142 on the moneyline.
• Contests with the Phillies have gone over the total set by oddsmakers in 73 of 151 chances this season.
• In 151 games with a line this season, the Phillies have a mark of 64-87-0 against the spread.
• The Brewers have gone 16-15 in games they were listed as the moneyline underdog (winning 51.6% of those games).
• Milwaukee has a record of 3-4 when it has played as a moneyline underdog with odds of +120 or longer (42.9%).
• The Brewers have played in 155 games with an over/under set, and have combined with their opponents to go over the total 68 times (68-82-5).
• The Brewers have put together an 80-75-0 record ATS this season.

Phillies Player Leaders

• Bryce Harper leads Philadelphia with an OBP of .382 this season while batting .271 with 104 walks and 92 runs scored. He has a slugging percentage of .491.
• Among qualified hitters in baseball, he is 39th in batting average, seventh in on-base percentage, and 18th in slugging.
• Harper will look for his third straight game with a hit in this contest. During his last five outings he is hitting .286 with a double, two walks and two RBIs.
• Luis Arraez has hit six homers this season while driving in 64 runs. He's batting .313 this season and slugging .424 with an on-base percentage of .348.
• His batting average is first among qualified players, his on-base percentage 45th, and his slugging percentage 68th.
• Arraez enters this game looking to extend his two-game hit streak. During his last five outings he is hitting .235 with a double, four walks and four RBIs.
• Kyle Schwarber has 131 hits and is batting .234 this season.
• Trea Turner has been key for Philadelphia with 149 hits, an OBP of .299 plus a slugging percentage of .382.
• Turner has safely hit in three straight games. In his last five games he is hitting .235 with a double, seven walks and an RBI.

Brewers Player Leaders

• Brice Turang is hitting .266 with 34 doubles, three triples, 19 home runs and 89 walks. He's slugging .440 with an on-base percentage of .367.
• Including all the qualified hitters in the majors, he ranks 48th in batting average, 16th in on-base percentage and 53rd in slugging percentage.
• William Contreras paces his team with a .423 slugging percentage. He has a batting average of .271 with an on-base percentage of .342.
• His batting average is 39th among all qualified players, his on-base percentage is 52nd, and he is 71st in slugging.
• Jake Bauers has an on-base percentage of .397 and has 122 hits, both team-best figures for the Brewers.
• Jackson Chourio has 27 doubles, 24 home runs and 44 walks while hitting .285.

Phillies vs Brewers Head to Head

• 6/14/2026: 4-0 MIL (Favorite: Phillies, Spread: -1.5, Total: 6.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/13/2026: 9-8 PHI (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/12/2026: 6-0 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 9/4/2025: 2-0 PHI (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/3/2025: 6-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/1/2025: 10-8 PHI (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 6/1/2025: 5-2 MIL (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 5/31/2025: 17-7 MIL (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 5/30/2025: 6-2 MIL (Favorite: Phillies, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/18/2024: 2-1 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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