Phillies vs Brewers Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 22

Odds updated as of 1:11 a.m.

Tuesday's slate in the MLB includes a matchup between the Philadelphia Phillies and the Milwaukee Brewers.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this matchup.

Phillies vs Brewers Game Info

• Philadelphia Phillies (86-70) vs. Milwaukee Brewers (98-58)
• Date: Tuesday, September 22, 2026
• Time: 6:40 p.m. ET
• Venue: Citizens Bank Park -- Philadelphia, Pennsylvania
• Coverage: NBCS-PH and Brewers.TV

Phillies vs Brewers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PHI: (-142) | MIL: (+120)
• Spread: PHI: -1.5 (+158) | MIL: +1.5 (-192)
• Total: 7.5 -- Over: (+106) | Under: (-130)

Phillies vs Brewers Probable Starting Pitchers

Probable Pitchers: Zack Wheeler (Phillies) - 13-5, 2.99 ERA vs Dustin May (Brewers) - 7-9, 4.61 ERA

The Phillies will give the ball to Zack Wheeler (13-5, 2.99 ERA), who is eyeing win No. 14 on the season, and the Brewers will turn to Dustin May (7-9, 4.61 ERA). Wheeler's team is 14-9-0 against the spread this season in his starts. When Wheeler starts a game and his team is the favorite on the moneyline, they have a record of 14-4. The Brewers have gone 14-15-0 against the spread when May starts. The Brewers have a 5-9 record in May's 14 starts this season when they were the moneyline underdog.

Phillies vs Brewers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (50.8%)

Phillies vs Brewers Moneyline

• Looking at the moneyline for Brewers-Phillies, Milwaukee is the underdog at +120, and Philadelphia is -142 playing at home.

Phillies vs Brewers Spread

• The Brewers are at +1.5 on the runline against the Phillies. The Brewers are -192 to cover the spread, and the Phillies are +158.

Phillies vs Brewers Over/Under

• A combined run total of 7.5 has been set for Phillies-Brewers on Sept. 22, with the over at +106 and the under at -130.

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Phillies vs Brewers Betting Trends

• The Phillies have won in 73, or 64.6%, of the 113 contests they have been named as odds-on favorites in this year.
• Philadelphia has a record of 58-19 in contests when oddsmakers favor them by -142 or more on the moneyline.
• Contests with the Phillies have gone over the total set by sportsbooks in 73 of 151 chances this season.
• The Phillies have an against the spread mark of 64-87-0 in 151 games with a line this season.
• The Brewers have won 16 of the 31 games they were listed as the moneyline underdog this season (51.6%).
• When playing as a moneyline underdog with odds of +120 or longer, Milwaukee has a 3-4 record (winning 42.9% of its games).
• The Brewers have played in 155 games with an over/under set, and have combined with their opponents to go over the total 68 times (68-82-5).
• The Brewers have covered 51.6% of their games this season, going 80-75-0 against the spread.

Phillies Player Leaders

• Bryce Harper leads Philadelphia in OBP (.382) this season, fueled by 150 hits. He has a .271 batting average and a slugging percentage of .491.
• Among all qualifying batters, he is 39th in batting average, his on-base percentage ranks seventh, and he is 18th in slugging.
• Harper has picked up at least one hit in two games in a row. In his last five games he is batting .286 with a double, two walks and two RBIs.
• Luis Arraez has hit six homers this season while driving in 64 runs. He's batting .313 this season and slugging .424 with an on-base percentage of .348.
• He is first in batting average, 45th in on-base percentage and 68th in slugging among qualified hitters.
• Arraez takes a two-game streak with at least one hit into this matchup. In his last five games he is hitting .235 with a double, four walks and four RBIs.
• Kyle Schwarber leads Philadelphia with 131 hits. He is batting .234 this season and 64 of his hits have gone for extra bases.
• Trea Turner has been key for Philadelphia with 149 hits, an OBP of .299 plus a slugging percentage of .382.
• Turner takes a three-game hitting streak into this game. During his last five outings he is batting .235 with a double, seven walks and an RBI.

Brewers Player Leaders

• Brice Turang has 34 doubles, three triples, 19 home runs and 89 walks while hitting .266. He's slugging .440 with an on-base percentage of .367.
• He is 48th in batting average, 17th in on-base percentage and 53rd in slugging percentage among all qualifying hitters in the big leagues.
• William Contreras' .423 slugging percentage leads his team. He has a batting average of .271 with an on-base percentage of .342.
• Including all qualified hitters, he ranks 39th in batting average, 52nd in on-base percentage and 71st in slugging percentage.
• Jake Bauers has put up a team-best OBP (.397), while pacing the Brewers in hits (122).
• Jackson Chourio is batting .285 with 27 doubles, 24 home runs and 44 walks.

Phillies vs Brewers Head to Head

• 6/14/2026: 4-0 MIL (Favorite: Phillies, Spread: -1.5, Total: 6.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/13/2026: 9-8 PHI (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/12/2026: 6-0 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 9/4/2025: 2-0 PHI (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/3/2025: 6-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/1/2025: 10-8 PHI (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 6/1/2025: 5-2 MIL (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 5/31/2025: 17-7 MIL (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 5/30/2025: 6-2 MIL (Favorite: Phillies, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/18/2024: 2-1 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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