Penn State vs Nebraska Prediction, Odds, Picks, Best Bets for Week 13 2025

The Saturday schedule in college football includes a matchup between the Penn State Nittany Lions and the Nebraska Cornhuskers.

Get the latest NCAA football odds ahead of this game on FanDuel Sportsbook.

Penn State vs Nebraska Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Penn State: (-295) | Nebraska: (+240)
• Spread: Penn State: -7.5 (-106) | Nebraska: +7.5 (-114)
• Total: 45.5 -- Over: (-108) | Under: (-112)

Penn State vs Nebraska Betting Trends

• Against the spread, Penn State is 3-7-0 this year.
• Penn State has won once ATS (1-5) as a 7.5-point or higher favorite this year.
• This year, seven of Penn State's 10 games have gone over the point total.
• Nebraska's record against the spread in 2025 is 4-6-0.
• Of 10 Nebraska games so far this season, seven have gone over the total.

Penn State vs Nebraska Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Nittany Lions win (69.5%)

Penn State vs Nebraska Point Spread

Penn State is a 7.5-point favorite against Nebraska. Penn State is -106 to cover the spread, and Nebraska is -114.

Penn State vs Nebraska Over/Under

A total of 45.5 points has been set for the Penn State-Nebraska matchup on Nov. 22, with the over available at -108 and the under at -112.

Penn State vs Nebraska Moneyline

Nebraska is a +240 underdog on the moneyline, while Penn State is a -295 favorite.

Penn State vs. Nebraska Points Insights

Penn State vs. Nebraska Game Info

• Game day: Saturday, November 22, 2025
• Game time: 7 p.m. ET
• TV channel: NBC
• Location: University Park, Pennsylvania
• Stadium: West Shore Home Field at Beaver Stadium

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Check out even more in-depth Penn State vs. Nebraska analysis on FanDuel Research.