Penn State vs Michigan State Prediction, Odds, Picks, Best Bets for Week 12 2025

The Penn State Nittany Lions will take on the Michigan State Spartans in college football action on Saturday.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding today's NCAA football betting odds.

Penn State vs Michigan State Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Penn State: (-270) | Michigan State: (+220)
• Spread: Penn State: -7.5 (100) | Michigan State: +7.5 (-122)
• Total: 49.5 -- Over: (-105) | Under: (-115)

Penn State vs Michigan State Betting Trends

• Penn State has won twice against the spread this season.
• Penn State has yet to win ATS (0-5) when playing as at least 7.5-point favorites this season.
• There have been seven Penn State games (of nine) that hit the over this season.
• Against the spread, Michigan State is 5-4-0 this year.
• Michigan State has yet to lose ATS (4-0) as a 7.5-point underdog or more this season.
• Michigan State has played nine games this year, and six of them have hit the over.

Penn State vs Michigan State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Nittany Lions win (74.3%)

Penn State vs Michigan State Point Spread

Penn State is favored by 7.5 points over Michigan State. Penn State is +100 to cover the spread, with Michigan State being -122.

Penn State vs Michigan State Over/Under

Penn State versus Michigan State on Nov. 15 has an over/under of 49.5 points, with the over -105 and the under -115.

Penn State vs Michigan State Moneyline

Looking at the moneyline for Penn State-Michigan State, Penn State is the favorite at -270, and Michigan State is +220.

Penn State vs. Michigan State Points Insights

Penn State vs. Michigan State Game Info

• Game day: Saturday, November 15, 2025
• Game time: 3:30 p.m. ET
• TV channel: CBS
• Location: East Lansing, Michigan
• Stadium: Spartan Stadium

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Check out even more in-depth Penn State vs. Michigan State analysis on FanDuel Research.