Penn State vs Buffalo Prediction, Odds, Picks, Best Bets for Week 3 2026

The Penn State Nittany Lions are among the college football teams busy on Saturday, up against the Buffalo Bulls.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Penn State vs Buffalo Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Penn State: (N/A) | Buffalo: (N/A)
• Spread: Penn State: -40.5 (-115) | Buffalo: +40.5 (-105)
• Total: 49.5 -- Over: (-115) | Under: (-105)

Penn State vs Buffalo Betting Trends

• Penn State hasn won once against the spread this year.
• Buffalo has not won a game against the spread this season.
• One of Buffalo's two games has gone over the point total.

Penn State vs Buffalo Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Nittany Lions win (97.8%)

Penn State vs Buffalo Point Spread

Buffalo is an underdog by 40.5 points versus Penn State. Buffalo is -105 to cover the spread, and Penn State is -115.

Penn State vs Buffalo Over/Under

The over/under for Penn State-Buffalo on Sept. 19 is 49.5. The over is -115, and the under is -105.

Penn State vs. Buffalo Points Insights

Penn State vs. Buffalo Game Info

• Game day: Saturday, September 19, 2026
• Game time: 12 p.m. ET
• TV channel: BTN
• Location: University Park, Pennsylvania
• Stadium: West Shore Home Field at Beaver Stadium

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Check out even more in-depth Penn State vs. Buffalo analysis on FanDuel Research.