Penn State vs Buffalo Prediction, Odds, Picks, Best Bets for Week 3 2026

The Penn State Nittany Lions versus the Buffalo Bulls is on the college football schedule for Saturday.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Penn State vs Buffalo Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Penn State: (N/A) | Buffalo: (N/A)
• Spread: Penn State: -40.5 (-115) | Buffalo: +40.5 (-105)
• Total: 49.5 -- Over: (-106) | Under: (-114)

Penn State vs Buffalo Betting Trends

• Penn State has one win against the spread this year.
• Buffalo is winless against the spread this season.
• One of Buffalo's two games has gone over the point total.

Penn State vs Buffalo Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Nittany Lions win (92.9%)

Penn State vs Buffalo Point Spread

Penn State is favored by 40.5 points (-115 to cover) in this matchup. Buffalo, the underdog, is -105.

Penn State vs Buffalo Over/Under

The Penn State-Buffalo matchup on Sept. 19 has been given an over/under of 49.5 points. The over is -106 and the under is -114.

Penn State vs. Buffalo Points Insights

Penn State vs. Buffalo Game Info

• Game day: Saturday, September 19, 2026
• Game time: 12 p.m. ET
• TV channel: BTN
• Location: University Park, Pennsylvania
• Stadium: West Shore Home Field at Beaver Stadium

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Check out even more in-depth Penn State vs. Buffalo analysis on FanDuel Research.