Patrick Mahomes Fantasy Football Week 12: Stats and Projections vs. Colts

In Week 12 (Sunday at 1 p.m. ET), QB Patrick Mahomes and the Kansas City Chiefs will play the Indianapolis Colts, who have the 25th-ranked pass defense in the league (235.3 yards conceded per game).

With Mahomes' next game versus the Colts, should you think about him for your daily fantasy lineup? See below for more stats and information.

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Patrick Mahomes Week 12 Fantasy Football Projection

• Matchup: Kansas City Chiefs vs. Indianapolis Colts
• Game Date: November 23, 2025
• Game Time: 1 p.m.
• Projected Fantasy Points: 19.5
• Projected Passing Yards: 255.48
• Projected Passing TDs: 1.82
• Projected Rushing Yards: 22.44
• Projected Rushing TDs: 0.21

Projections provided by numberFire

Mahomes Fantasy Performance

• Mahomes has been coming through for fantasy managers this season, as his 219.8 fantasy points (22.0 per game) rank him third at the QB position and fourth overall.
• Through his last three games, Mahomes has completed 69-of-113 passes for 825 yards, with four passing touchdowns and four interceptions, resulting in 46.8 total fantasy points (15.6 per game). With his legs, he's added 38 rushing yards on six attempts.
• Mahomes has amassed 104.5 fantasy points (20.9 per game) in his last five games, connecting on 117-of-178 throws for 1,368 yards, with 10 touchdowns and four interceptions. He's added 98 rushing yards on 20 carries with one touchdown on the ground.
• The peak of Mahomes' fantasy season so far was Week 6 against the Detroit Lions, when he completed 73.3% of his passes for 257 yards and three touchdowns with zero interceptions on his way to 31.5 fantasy points. He also had 32 rushing yards on 10 attempts (3.2 YPC) with one touchdown on the ground.
• From a fantasy perspective, Patrick Mahomes' matchup against the Buffalo Bills in Week 9 was his worst of the year, as he posted 10.5 fantasy points. He passed for 250 yards and zero touchdowns, and threw one pick on the day.

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Colts Defensive Performance

• Indianapolis has allowed three players to rack up over 300 yards passing in a game this year.
• The Colts have given up at least one passing TD to nine opposing QBs this year.
• A total of four players have thrown for at least two touchdowns versus Indianapolis this year.
• Three players have passed for at least three TDs in a game versus the Colts this year.
• A total of four players have racked up more than 100 yards receiving in a game versus Indianapolis this year.
• A total of 16 players have caught a touchdown pass versus the Colts this year.
• Indianapolis has not allowed an opposing player to catch two or more touchdown passes in a game this year.
• The Colts have not allowed more than 100 yards rushing to an opposing player this year.
• Indianapolis has allowed at least one rushing touchdown to six players this year.
• Just two players have rushed for more than one TD against the Colts this season.

Want more data and analysis on Patrick Mahomes? Check out FanDuel Research for all the latest and in-depth fantasy and betting coverage.