Padres vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 23

Odds updated as of 11:12 p.m.

The Sunday schedule in MLB includes a matchup between the San Diego Padres and the Minnesota Twins.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Padres vs Twins Game Info

• San Diego Padres (69-60) vs. Minnesota Twins (63-66)
• Date: Sunday, August 23, 2026
• Time: 4:10 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and Twins.TV

Padres vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-134) | MIN: (+116)
• Spread: SD: -1.5 (+146) | MIN: +1.5 (-176)
• Total: 8.5 -- Over: (-115) | Under: (-105)

Padres vs Twins Probable Starting Pitchers

Probable Pitchers: Walker Buehler (Padres) - 7-6, 4.79 ERA vs Bailey Ober (Twins) - 7-4, 4.62 ERA

The Padres will give the ball to Walker Buehler (7-6, 4.79 ERA), who is eyeing win No. 8 on the season, and the Twins will counter with Bailey Ober (7-4, 4.62 ERA). Buehler and his team are 18-7-0 ATS this season when he starts. When Buehler starts a game and his team is the favorite on the moneyline, they have a record of 6-3. The Twins have gone 11-7-0 against the spread when Ober starts. The Twins have been the underdog on the moneyline in 12 of Ober's starts this season, and they went 8-4 in those games.

Padres vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (59%)

Padres vs Twins Moneyline

• Looking at the moneyline for Twins-Padres, Minnesota is the underdog at +116, and San Diego is -134 playing at home.

Padres vs Twins Spread

• The Padres are hosting the Twins and are favored by 1.5 runs (+146 to cover) on the runline. Minnesota is -176 to cover.

Padres vs Twins Over/Under

• An over/under of 8.5 has been set for Padres-Twins on Aug. 23, with the over being -115 and the under -105.

Bet on San Diego Padres vs. Minnesota Twins on FanDuel today!

Padres vs Twins Betting Trends

• The Padres have been chosen as favorites in 55 games this year and have walked away with the win 31 times (56.4%) in those games.
• This year San Diego has won 16 of 26 games when listed as at least -134 on the moneyline.
• The Padres and their opponents have hit the over in 56 of their 129 games with a total set by oddsmakers this season.
• The Padres are 74-55-0 against the spread in their 129 games with a line set by sportsbooks this season.
• The Twins have won 36 of the 79 games they were the moneyline underdog this season (45.6%).
• Minnesota is 22-24 (winning 47.8% of its games) when it has played as a moneyline underdog of +116 or longer.
• In the 126 games bookmakers have set an over/under for the Twins, they have combined with opponents to go over the total 69 times (69-54-3).
• The Twins have put together a 69-57-0 record against the spread this season.

Padres Player Leaders

• Fernando Tatis Jr. has 140 hits and an OBP of .357 to go with a slugging percentage of .438. All three of those stats are best among San Diego hitters this season. He has a .284 batting average, as well.
• Among qualifying hitters in the majors, he is 22nd in batting average, 35th in on-base percentage, and 57th in slugging.
• Tatis hopes to build on a three-game hitting streak in this matchup. During his last five outings he is hitting .400 with two doubles, two home runs, a walk and six RBIs.
• Manny Machado is batting .217 with 20 doubles, 24 home runs and 58 walks, while slugging .414 with an on-base percentage of .301.
• He is 126th in batting average, 115th in on-base percentage and 82nd in slugging among qualified hitters.
• Jackson Merrill has collected 116 base hits, an OBP of .288 and a slugging percentage of .405 this season.
• Xander Bogaerts is batting .218 with a .318 OBP and 46 RBI for San Diego this season.

Twins Player Leaders

• Josh Bell has a .430 slugging percentage, which leads the Twins. He's batting .257 with an on-base percentage of .321.
• Including all the qualifying hitters in the majors, his batting average is 70th, his on-base percentage ranks 86th, and he is 62nd in slugging.
• Brooks Lee has 19 doubles, three triples, 18 home runs and 33 walks while batting .242. He's slugging .416 with an on-base percentage of .297.
• Including all qualifying hitters, his batting average places him 96th, his on-base percentage ranks 121st, and he is 79th in slugging.
• Kody Clemens has racked up 98 hits, a team-best for the Twins.
• Luke Keaschall's .363 OBP paces his team.

Padres vs Twins Head to Head

• 8/21/2026: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: +108)
• 8/31/2025: 7-2 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/30/2025: 12-3 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/29/2025: 7-4 MIN (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/21/2024: 11-4 MIN (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/20/2024: 7-5 SD (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/19/2024: 5-3 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 5/11/2023: 5-3 MIN (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/10/2023: 4-3 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/9/2023: 6-1 SD (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!