Padres vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 22

Odds updated as of 5:12 a.m.

The San Diego Padres will face the Minnesota Twins in MLB action on Saturday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding this game.

Padres vs Twins Game Info

• San Diego Padres (69-60) vs. Minnesota Twins (63-66)
• Date: Saturday, August 22, 2026
• Time: 8:40 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and Twins.TV

Padres vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-162) | MIN: (+136)
• Spread: SD: -1.5 (+134) | MIN: +1.5 (-162)
• Total: 8 -- Over: (-118) | Under: (-104)

Padres vs Twins Probable Starting Pitchers

Probable Pitchers: Casey Mize (Padres) - 5-7, 3.18 ERA vs Dean Kremer (Twins) - 2-4, 5.40 ERA

The Padres will look to Casey Mize (5-7) versus the Twins and Dean Kremer (2-4). Mize's team is 10-9-0 against the spread this season in his starts. When Mize starts a game and his team is the favorite on the moneyline, they have a record of 5-5. When Kremer starts, the Twins have gone 3-7-0 against the spread. The Twins have a 2-5 record in Kremer's seven starts this season when they were the moneyline underdog.

Padres vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (60.5%)

Padres vs Twins Moneyline

• Looking at the moneyline for Padres-Twins, San Diego is the favorite at -162, and Minnesota is +136 playing on the road.

Padres vs Twins Spread

• The Padres are favored by 1.5 runs at home against the Twins. The Padres are +134 to cover the spread, while the Twins are -162.

Padres vs Twins Over/Under

• The over/under for Padres-Twins on Aug. 22 is 8. The over is -118, and the under is -104.

Bet on San Diego Padres vs. Minnesota Twins on FanDuel today!

Padres vs Twins Betting Trends

• The Padres have won in 31, or 56.4%, of the 55 contests they have been named as odds-on favorites in this year.
• San Diego has a record of 7-5 when favored by -162 or more this year.
• The Padres and their opponents have gone over in 56 of their 129 games with a total set by sportsbooks this season.
• In 129 games with a line this season, the Padres have a mark of 74-55-0 against the spread.
• The Twins are 36-43 in games they were listed as the moneyline underdog (winning 45.6% of those games).
• Minnesota has a record of 6-9 when playing as a moneyline underdog with odds of +136 or longer (40%).
• The Twins have had an over/under set by bookmakers 126 times, and have combined with opponents to go over the total in 69 of those games (69-54-3).
• The Twins have covered 54.8% of their games this season, going 69-57-0 ATS.

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego with 140 hits and an OBP of .357, plus a team-best slugging percentage of .438. He's batting .284.
• Among all qualified hitters, he is 22nd in batting average, his on-base percentage ranks 37th, and he is 59th in slugging.
• Tatis hopes to build on a three-game hitting streak in this matchup. In his last five games he is batting .400 with two doubles, two home runs, a walk and six RBIs.
• Manny Machado is batting .217 with 20 doubles, 24 home runs and 58 walks. He's slugging .414 with an on-base percentage of .301.
• Among qualified batters, he is 128th in batting average, 117th in on-base percentage and 83rd in slugging percentage.
• Jackson Merrill has 116 hits this season and has a slash line of .238/.288/.405.
• Xander Bogaerts has 11 home runs, 46 RBI and a batting average of .218 this season.

Twins Player Leaders

• Josh Bell has racked up a slugging percentage of .430, a team-best for the Twins. He's batting .257 with an on-base percentage of .321.
• Including all qualified hitters in MLB, he is 69th in batting average, 86th in on-base percentage and 62nd in slugging percentage.
• Brooks Lee is hitting .242 with 19 doubles, three triples, 18 home runs and 33 walks. He's slugging .416 with an on-base percentage of .297.
• His batting average is 96th among all qualified players, his on-base percentage is 122nd, and he is 81st in slugging.
• Kody Clemens paces the Twins with 98 hits.
• Luke Keaschall has a .363 on-base percentage to lead his team.

Padres vs Twins Head to Head

• 8/21/2026: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: +108)
• 8/31/2025: 7-2 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/30/2025: 12-3 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/29/2025: 7-4 MIN (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/21/2024: 11-4 MIN (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/20/2024: 7-5 SD (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/19/2024: 5-3 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 5/11/2023: 5-3 MIN (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/10/2023: 4-3 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/9/2023: 6-1 SD (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!