Padres vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 2

Odds updated as of 9:12 p.m.

The MLB's Wednesday slate includes the San Diego Padres taking on the Cincinnati Reds.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Padres vs Reds Game Info

• San Diego Padres (73-65) vs. Cincinnati Reds (65-73)
• Date: Wednesday, September 2, 2026
• Time: 12:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: Reds.TV and Padres.TV

Padres vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-144) | CIN: (+122)
• Spread: SD: -1.5 (+112) | CIN: +1.5 (-134)
• Total: 9.5 -- Over: (-105) | Under: (-115)

Padres vs Reds Probable Starting Pitchers

Probable Pitchers: Casey Mize (Padres) - 5-8, 3.45 ERA vs Brandon Williamson (Reds) - 2-3, 6.11 ERA

The Padres will give the nod to Casey Mize (5-8, 3.45 ERA), who is eyeing win No. 6 on the season, and the Reds will counter with Brandon Williamson (2-3, 6.11 ERA). When Mize starts, his team is 11-10-0 against the spread this season. Mize's team has won 54.5% of his starts when they are favored on the moneyline (6-5). The Reds are 3-3-0 ATS in Williamson's six starts that had a set spread. The Reds have a 2-2 record in Williamson's four starts this season when they were the underdog on the moneyline.

Padres vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (61.3%)

Padres vs Reds Moneyline

• Cincinnati is the underdog, +122 on the moneyline, while San Diego is a -144 favorite despite being on the road.

Padres vs Reds Spread

• The Reds are +1.5 on the run line against the Padres. The Reds are -134 to cover, and the Padres are +112.

Padres vs Reds Over/Under

• Padres versus Reds, on Sept. 2, has an over/under of 9.5, with the over being -105 and the under -115.

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Padres vs Reds Betting Trends

• The Padres have been victorious in 35, or 57.4%, of the 61 contests they have been chosen as favorites in this season.
• This year San Diego has won 15 of 23 games when listed as at least -144 on the moneyline.
• The Padres and their opponents have hit the over in 61 of their 138 games with a total set by oddsmakers this season.
• The Padres have an against the spread record of 81-57-0 in 138 games with a line this season.
• The Reds have gone 43-48 in games they were the underdog on the moneyline (winning 47.3% of those games).
• Cincinnati has a record of 13-21 when playing as a moneyline underdog with odds of +122 or longer (38.2%).
• The Reds have played in 135 games with a set over/under, and have combined with opponents to go over the total 72 times (72-61-2).
• The Reds are 69-66-0 against the spread this season.

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego in OBP (.349), slugging percentage (.438) and total hits (150) this season. He has a .281 batting average.
• Among qualifying hitters in MLB, his batting average ranks 24th, his on-base percentage ranks 42nd, and he is 53rd in slugging.
• Manny Machado is hitting .220 with 21 doubles, 24 home runs and 65 walks. He's slugging .405 with an on-base percentage of .307.
• Among all qualifying players, he ranks 125th in batting average, 108th in on-base percentage and 87th in slugging percentage.
• Machado heads into this game looking to extend his three-game hit streak. During his last five outings he is batting .381 with a double, two walks and two RBIs.
• Jackson Merrill has 126 hits this season and has a slash line of .241/.294/.419.
• Merrill heads into this game with two games in a row with at least one hit. During his last five outings he is hitting .368 with a double, a triple, a home run, three walks and four RBIs.
• Xander Bogaerts has been key for San Diego with 97 hits, an OBP of .316 plus a slugging percentage of .322.
• Bogaerts heads into this game on a two-game hitting streak. During his last five outings he is batting .176 with a double, a walk and four RBIs.

Reds Player Leaders

• Sal Stewart has a slugging percentage of .489 and has 141 hits, both team-high marks for the Reds. He's batting .266 and with an on-base percentage of .337.
• Including all the qualified hitters in MLB, his batting average places him 51st, his on-base percentage ranks 62nd, and he is 23rd in slugging.
• Stewart heads into this matchup on a four-game hitting streak. In his last five games he is hitting .350 with a double, three home runs, two walks and six RBIs.
• Elly De La Cruz has a .351 OBP to pace his team. He has a batting average of .270 while slugging .477.
• Including all qualified hitters, he ranks 45th in batting average, 40th in on-base percentage and 26th in slugging percentage.
• JJ Bleday is hitting .216 with 14 doubles, two triples, 21 home runs and 64 walks.
• Tyler Stephenson is hitting .251 with 19 doubles, 14 home runs and 41 walks.

Padres vs Reds Head to Head

• 8/31/2026: 5-0 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -144, Underdog Moneyline: +134)
• 6/10/2026: 5-4 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 6/9/2026: 5-3 CIN (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/8/2026: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/10/2025: 2-1 CIN (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/9/2025: 4-2 CIN (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 9/8/2025: 4-3 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/29/2025: 3-2 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/28/2025: 6-4 SD (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/27/2025: 8-1 CIN (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)

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