Padres vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 2

Odds updated as of 12:12 p.m.

Wednesday's slate in the MLB includes a matchup between the San Diego Padres and the Cincinnati Reds.

We've got you covered, in terms of the most important information regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Padres vs Reds Game Info

• San Diego Padres (73-66) vs. Cincinnati Reds (66-73)
• Date: Wednesday, September 2, 2026
• Time: 12:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: Reds.TV and Padres.TV

Padres vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-156) | CIN: (+132)
• Spread: SD: -1.5 (+105) | CIN: +1.5 (-126)
• Total: 9.5 -- Over: (-102) | Under: (-120)

Padres vs Reds Probable Starting Pitchers

Probable Pitchers: Casey Mize (Padres) - 5-8, 3.45 ERA vs Brandon Williamson (Reds) - 2-3, 6.11 ERA

The Padres will give the nod to Casey Mize (5-8, 3.45 ERA), who is eyeing win No. 6 on the season, and the Reds will turn to Brandon Williamson (2-3, 6.11 ERA). Mize's team is 11-10-0 against the spread this season in his starts. Mize's team is 6-5 this season when he starts and they are the moneyline favorite. The Reds have a 3-3-0 record against the spread in Williamson's starts. The Reds have a 2-2 record in Williamson's four starts this season when they were the underdog on the moneyline.

Padres vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (65.3%)

Padres vs Reds Moneyline

• Looking at the moneyline for Reds-Padres, Cincinnati is the underdog at +132, and San Diego is -156 playing on the road.

Padres vs Reds Spread

• The Reds are +1.5 on the run line against the Padres. The Reds are -126 to cover, and the Padres are +105.

Padres vs Reds Over/Under

• A combined run total of 9.5 has been set for Padres-Reds on Sept. 2, with the over at -102 and the under at -120.

Bet on San Diego Padres vs. Cincinnati Reds on FanDuel today!

Padres vs Reds Betting Trends

• The Padres have won in 35, or 56.5%, of the 62 contests they have been named as odds-on favorites in this year.
• This season San Diego has come away with a win nine times in 15 chances when named as a favorite of at least -156 on the moneyline.
• The Padres' games have gone over the total in 61 of their 139 opportunities.
• The Padres have an against the spread mark of 81-58-0 in 139 games with a line this season.
• The Reds have compiled a 44-48 record in games they were listed as the moneyline underdog (winning 47.8% of those games).
• In games it has played as a moneyline underdog with odds of +132 or longer, Cincinnati has gone 10-13 (43.5%).
• In the 136 games oddsmakers have set an over/under for the Reds, they have combined with opponents to go over the total 72 times (72-62-2).
• The Reds have a 70-66-0 record against the spread this season (covering 51.5% of the time).

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego with 152 hits and an OBP of .349, plus a team-best slugging percentage of .449. He's batting .282.
• He ranks 21st in batting average, 44th in on-base percentage, and 45th in slugging among qualifying hitters in MLB.
• Tatis will look for his third straight game with a hit in this contest. During his last five outings he is hitting .217 with a double, two home runs and two RBIs.
• Manny Machado is batting .219 with 21 doubles, 24 home runs and 66 walks. He's slugging .403 with an on-base percentage of .306.
• He ranks 127th in batting average, 111th in on-base percentage and 92nd in slugging among qualified hitters.
• Jackson Merrill is batting .243 with a .421 slugging percentage and 70 RBI this year.
• Merrill heads into this matchup with three games in a row with at least one hit. In his last five games he is hitting .350 with a double, a home run, two walks and three RBIs.
• Xander Bogaerts has 11 home runs, 51 RBI and a batting average of .216 this season.

Reds Player Leaders

• Sal Stewart has accumulated 143 hits with a .489 slugging percentage, both team-best stats for the Reds. He's batting .268 and with an on-base percentage of .338.
• Including all qualifying hitters, he ranks 50th in batting average, while his on-base percentage is 58th and he is 22nd in slugging.
• Stewart hopes to build on a five-game hitting streak in this matchup. In his last five games he is hitting .429 with a double, three home runs, a walk and five RBIs.
• Elly De La Cruz leads his team with a .352 OBP. He has a batting average of .271 while slugging .476.
• Including all qualified hitters, he ranks 44th in batting average, 39th in on-base percentage and 28th in slugging percentage.
• JJ Bleday has 14 doubles, two triples, 21 home runs and 64 walks while batting .217.
• Tyler Stephenson is batting .251 with 19 doubles, 14 home runs and 41 walks.

Padres vs Reds Head to Head

• 9/1/2026: 4-3 CIN (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 8/31/2026: 5-0 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -144, Underdog Moneyline: +134)
• 6/10/2026: 5-4 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 6/9/2026: 5-3 CIN (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/8/2026: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/10/2025: 2-1 CIN (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/9/2025: 4-2 CIN (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 9/8/2025: 4-3 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/29/2025: 3-2 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/28/2025: 6-4 SD (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -156, Underdog Moneyline: +132)

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