Padres vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 27

Odds updated as of 10:14 p.m.

Sunday's slate in the MLB includes a matchup between the San Diego Padres and the Arizona Diamondbacks.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Padres vs Diamondbacks Game Info

• San Diego Padres (89-71) vs. Arizona Diamondbacks (86-74)
• Date: Sunday, September 27, 2026
• Time: 3:10 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and Dbacks.TV

Padres vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-120) | ARI: (+102)
• Spread: SD: +1.5 (-205) | ARI: -1.5 (+172)
• Total: 7.5 -- Over: (-118) | Under: (-104)

Padres vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: TBA (Padres) vs Mike Soroka (Diamondbacks) - 9-5, 0.00 ERA

Soroka (9-5) will take the ball for the Diamondbacks. As of this writing, there's been no pitching decision announced by the Padres. The Diamondbacks are 10-9-0 against the spread when Soroka starts. The Diamondbacks have been the moneyline underdog in five of Soroka's starts this season, and they went 1-4 in those matchups.

Padres vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (53.4%)

Padres vs Diamondbacks Moneyline

• The Padres vs Diamondbacks moneyline has San Diego as a -120 favorite, while Arizona is a +102 underdog on the road.

Padres vs Diamondbacks Spread

• The Diamondbacks are 1.5-run favorites against the spread for this matchup with the Padres. The Diamondbacks are +172 to cover, while the Padres are -205 to cover as a 1.5-run underdog on the runline.

Padres vs Diamondbacks Over/Under

• The Padres-Diamondbacks contest on Sept. 27 has been given an over/under of 7.5 runs. The over is set at -118 and the under at -104.

Bet on San Diego Padres vs. Arizona Diamondbacks on FanDuel today!

Padres vs Diamondbacks Betting Trends

• The Padres have won in 48, or 60.8%, of the 79 contests they have been named as odds-on favorites in this year.
• This year San Diego has won 38 of 62 games when listed as at least -120 on the moneyline.
• The Padres' games have gone over the total in 75 of their 160 opportunities.
• The Padres have an against the spread record of 92-68-0 in 160 games with a line this season.
• The Diamondbacks have been the underdog on the moneyline 83 total times this season. They've finished 40-43 in those games.
• When it has played as a moneyline underdog with odds of +102 or longer, Arizona has a 32-35 record (winning 47.8% of its games).
• The Diamondbacks have played in 158 games with a set over/under, and have combined with opponents to go over the total 69 times (69-85-4).
• The Diamondbacks are 84-74-0 against the spread this season.

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego with 181 hits and an OBP of .360, plus a team-best slugging percentage of .473. He's batting .291.
• Among qualifying hitters, he ranks 10th in batting average, his on-base percentage ranks 30th, and he is 31st in slugging.
• Tatis has hit safely in eight straight games. In his last 10 outings he is batting .325 with three doubles, three home runs, three walks and five RBIs.
• Jackson Merrill is hitting .253 with 26 doubles, five triples, 26 home runs and 40 walks. He's slugging .440 with an on-base percentage of .301.
• He is 72nd in batting average, 116th in on-base percentage and 54th in slugging among qualifying hitters.
• Merrill has picked up at least one hit in two straight games. In his last five games he is batting .167 with a double.
• Manny Machado has collected 125 base hits, an OBP of .302 and a slugging percentage of .402 this season.
• Xander Bogaerts is batting .230 with a .329 OBP and 56 RBI for San Diego this season.

Diamondbacks Player Leaders

• Corbin Carroll is batting .239 with 32 doubles, 17 triples, 22 home runs and 73 walks. He's slugging .469 with an on-base percentage of .329.
• He ranks 97th in batting average, 70th in on-base percentage and 34th in slugging percentage among all qualifying hitters in the majors.
• Geraldo Perdomo is slugging .379 to lead his team. He has a batting average of .263 with an on-base percentage of .369.
• Including all qualified hitters, he is 54th in batting average, 16th in on-base percentage and 109th in slugging percentage.
• Gabriel Moreno has accumulated a team-best OBP (.387) and slugging percentage (.487), and leads the Diamondbacks in hits (146).
• Ketel Marte is batting .248 with 30 doubles, three triples, 22 home runs and 51 walks.

Padres vs Diamondbacks Head to Head

• 9/25/2026: 11-4 ARI (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/6/2026: 5-1 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -104, Underdog Moneyline: -104)
• 8/5/2026: 10-4 ARI (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +122)
• 8/4/2026: 9-4 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -114, Underdog Moneyline: +104)
• 8/3/2026: 5-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: +100)
• 7/9/2026: 3-1 ARI (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/8/2026: 10-4 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/7/2026: 4-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/6/2026: 8-0 ARI (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/26/2026: 12-7 ARI (Favorite: Padres, Spread: -1.5, Total: 15, Favorite Moneyline: -134, Underdog Moneyline: +114)

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