Padres vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 27

Odds updated as of 3:11 p.m.

In MLB action on Sunday, the San Diego Padres take on the Arizona Diamondbacks.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this game.

Padres vs Diamondbacks Game Info

• San Diego Padres (90-71) vs. Arizona Diamondbacks (86-75)
• Date: Sunday, September 27, 2026
• Time: 3:10 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and Dbacks.TV

Padres vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-120) | ARI: (+102)
• Spread: SD: +1.5 (-205) | ARI: -1.5 (+172)
• Total: 7.5 -- Over: (-118) | Under: (-104)

Padres vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Randy Vasquez (Padres) - 10-6, 4.01 ERA vs Mike Soroka (Diamondbacks) - 9-5, 3.31 ERA

The probable pitchers are Randy Vasquez (10-6) for the Padres and Mike Soroka (9-5) for the Diamondbacks. Vasquez's team is 15-7-0 against the spread this season in his starts. Vasquez's team has won 70% of his starts when they are favored on the moneyline (7-3). The Diamondbacks are 10-9-0 against the spread when Soroka starts. The Diamondbacks have been the moneyline underdog in five of Soroka's starts this season, and they went 1-4 in those games.

Padres vs Diamondbacks Moneyline

• San Diego is the favorite, -120 on the moneyline, while Arizona is a +102 underdog on the road.

Padres vs Diamondbacks Spread

• The Diamondbacks are 1.5-run favorites against the spread for this matchup with the Padres. The Diamondbacks are +172 to cover, while the Padres are -205 to cover as a 1.5-run underdog on the runline.

Padres vs Diamondbacks Over/Under

• The over/under for the Padres versus Diamondbacks game on Sept. 27 has been set at 7.5, with -118 odds on the over and -104 odds on the under.

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Padres vs Diamondbacks Betting Trends

• The Padres have been victorious in 49, or 61.3%, of the 80 contests they have been chosen as favorites in this season.
• San Diego has a record of 39-24 in contests when bookmakers favor them by -120 or more on the moneyline.
• The Padres' games have gone over the total in 76 of their 161 opportunities.
• The Padres are 93-68-0 against the spread in their 161 games that had a posted line this season.
• The Diamondbacks have compiled a 40-44 record in games they were listed as the moneyline underdog (winning 47.6% of those games).
• When it has played as a moneyline underdog with odds of +102 or longer, Arizona has a 32-35 record (winning 47.8% of its games).
• In the 159 games oddsmakers have set an over/under for the Diamondbacks, they have combined with opponents to go over the total 70 times (70-85-4).
• The Diamondbacks have put together an 84-75-0 record ATS this season (covering 52.8% of the time).

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego with 181 hits and an OBP of .358, plus a team-best slugging percentage of .470. He's batting .289.
• Among qualified hitters in MLB, his batting average ranks 12th, his on-base percentage ranks 35th, and he is 33rd in slugging.
• Jackson Merrill has 26 doubles, five triples, 26 home runs and 41 walks. He's batting .254 and slugging .440 with an on-base percentage of .303.
• Among all qualifying hitters, he is 71st in batting average, 113th in on-base percentage and 54th in slugging percentage.
• Merrill takes a three-game streak with at least one hit into this contest. In his last five games he is batting .222 with a double, a walk and an RBI.
• Manny Machado is batting .216 with a .407 slugging percentage and 90 RBI this year.
• Xander Bogaerts has 13 home runs, 57 RBI and a batting average of .231 this season.
• Bogaerts heads into this matchup on a two-game hitting streak. In his last five games he is batting .308 with a home run, four walks and an RBI.

Diamondbacks Player Leaders

• Corbin Carroll is batting .238 with 32 doubles, 17 triples, 22 home runs and 73 walks. He's slugging .466 with an on-base percentage of .328.
• Including all the qualifying hitters in the majors, he is 100th in batting average, 76th in on-base percentage and 36th in slugging percentage.
• Geraldo Perdomo has 20 doubles, nine triples, nine home runs and 95 walks while hitting .261. He's slugging .377 with an on-base percentage of .369.
• Including all qualified players, he is 57th in batting average, 16th in on-base percentage and 112th in slugging percentage.
• Gabriel Moreno has accumulated 147 hits with a .388 on-base percentage and a .486 slugging percentage, all club-highs for the Diamondbacks.
• Ketel Marte has 31 doubles, three triples, 22 home runs and 51 walks while hitting .249.

Padres vs Diamondbacks Head to Head

• 9/26/2026: 10-7 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/25/2026: 11-4 ARI (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/6/2026: 5-1 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -104, Underdog Moneyline: -104)
• 8/5/2026: 10-4 ARI (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +122)
• 8/4/2026: 9-4 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -114, Underdog Moneyline: +104)
• 8/3/2026: 5-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: +100)
• 7/9/2026: 3-1 ARI (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/8/2026: 10-4 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/7/2026: 4-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/6/2026: 8-0 ARI (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)

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