Padres vs Cubs Prediction, Odds, Moneyline, Spread & Over/Under for NL Wild Card Game 1 on Sept. 29

Odds updated as of 4:11 a.m.

In MLB action on Tuesday, the San Diego Padres take on the Chicago Cubs in Game 1 of the NL Wild Card Series.

We've got you covered, in terms of the most important info regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Padres vs Cubs Game Info

• San Diego Padres (91-71) vs. Chicago Cubs (89-73)
• Date: Tuesday, September 29, 2026
• Time: 10 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: NBCSN and Peacock

Padres vs Cubs Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-126) | CHC: (+108)
• Spread: SD: -1.5 (+176) | CHC: +1.5 (-215)
• Total: 7.5 -- Over: (+102) | Under: (-124)

Padres vs Cubs Probable Starting Pitchers

Probable Pitchers: Michael King (Padres) - 12-10, 3.21 ERA vs Matthew Boyd (Cubs) - 10-5, 3.91 ERA

The Padres will look to Michael King (12-10, 3.21 ERA) versus the Cubs and Matthew Boyd (10-5, 3.91 ERA). When King starts, his team is 12-20-0 against the spread this season. King's team has a record of 11-10 this season when he starts and they are the favorite on the moneyline. When Boyd starts, the Cubs have gone 10-11-0 against the spread. The Cubs are 1-4 in Boyd's five starts this season that they were the moneyline underdog.

Padres vs Cubs Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (53.1%)

Padres vs Cubs Moneyline

• Chicago is a +108 underdog on the moneyline, while San Diego is a -126 favorite at home.

Padres vs Cubs Spread

• The Padres are hosting the Cubs and are favored by 1.5 runs (+176 to cover) on the runline. Chicago is -215 to cover.

Padres vs Cubs Over/Under

• A total of 7.5 runs has been set for the Padres-Cubs contest on Sept. 29, with the over available at +102 and the under at -124.

Bet on San Diego Padres vs. Chicago Cubs on FanDuel today!

Padres vs Cubs Betting Trends

• The Padres have been victorious in 49, or 61.3%, of the 80 contests they have been chosen as favorites in this season.
• This season San Diego has been victorious 34 times in 55 chances when named as a favorite of at least -126 on the moneyline.
• The Padres and their opponents have hit the over in 77 of their 162 games with a total set by oddsmakers this season.
• The Padres have posted a record of 94-68-0 against the spread this season.
• The Cubs are 23-22 in games they were the underdog on the moneyline (winning 51.1% of those games).
• Chicago is 9-9 (winning 50% of its games) when playing as a moneyline underdog of +108 or longer.
• In the 157 games oddsmakers have set an over/under for the Cubs, they have combined with opponents to go over the total 89 times (89-68-0).
• The Cubs have collected a 74-83-0 record against the spread this season (covering 47.1% of the time).

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego with a slugging percentage of .470, fueled by 60 extra-base hits. He has a .289 batting average and an on-base percentage of .358.
• He is 13th in batting average, 36th in on-base percentage, and 34th in slugging among qualified batters in the majors.
• Jackson Merrill is hitting .254 with 26 doubles, five triples, 26 home runs and 41 walks. He's slugging .440 with an on-base percentage of .303.
• Among qualifying hitters, his batting average places him 74th, his on-base percentage 113th, and his slugging percentage 56th.
• Merrill takes a three-game streak with at least one hit into this matchup. In his last five games he is batting .222 with a double, a walk and an RBI.
• Manny Machado has collected 128 base hits, an OBP of .303 and a slugging percentage of .407 this season.
• Machado brings a two-game hitting streak into this matchup. During his last five outings he is hitting .211 with two home runs and seven RBIs.
• Xander Bogaerts has been key for San Diego with 120 hits, an OBP of .332 plus a slugging percentage of .344.
• Bogaerts has hit safely in two games in a row. During his last five outings he is batting .308 with a home run, four walks and an RBI.

Cubs Player Leaders

• Pete Crow-Armstrong has accumulated 175 hits with a .372 on-base percentage and a .570 slugging percentage, all club-bests for the Cubs. He's batting .280.
• Including all the qualifying players in MLB, his batting average ranks 26th, his on-base percentage is 14th, and he is second in slugging.
• Alex Bregman has 33 doubles, two triples, 28 home runs and 76 walks while batting .265. He's slugging .464 with an on-base percentage of .355.
• Including all qualified players, he is 48th in batting average, 39th in on-base percentage and 39th in slugging percentage.
• Seiya Suzuki is hitting .270 with 31 doubles, a triple, 26 home runs and 81 walks.
• Nico Hoerner is batting .263 with 29 doubles, a triple, eight home runs and 43 walks.

Padres vs Cubs Head to Head

• 7/1/2026: 23-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 12, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/30/2026: 9-7 CHC (Favorite: Cubs, Spread: -1.5, Total: 11.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 6/29/2026: 3-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 11.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 4/29/2026: 5-4 CHC (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/28/2026: 8-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 4/27/2026: 9-7 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 10/2/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 10/1/2025: 3-0 SD (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/30/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/16/2025: 4-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)

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