Orioles vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 8

Odds updated as of 2:12 a.m.

On Tuesday in MLB, the Baltimore Orioles are up against the Cleveland Guardians.

We've got you covered, in terms of the most important info about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Orioles vs Guardians Game Info

• Baltimore Orioles (70-75) vs. Cleveland Guardians (73-72)
• Date: Tuesday, September 8, 2026
• Time: 6:35 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN and CleGuardians.TV

Orioles vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-132) | CLE: (+112)
• Spread: BAL: -1.5 (+150) | CLE: +1.5 (-182)
• Total: 8.5 -- Over: (-120) | Under: (-102)

Orioles vs Guardians Probable Starting Pitchers

Probable Pitchers: Brandon Young (Orioles) - 9-3, 3.42 ERA vs Tanner Bibee (Guardians) - 5-15, 4.06 ERA

The Orioles will call on Brandon Young (9-3) against the Guardians and Tanner Bibee (5-15). Young's team is 19-5-0 against the spread in his starts this season. Young's team has a record of 8-3 this season when he starts and they are the favorite on the moneyline. When Bibee starts, the Guardians are 6-21-0 against the spread. The Guardians have been the underdog on the moneyline in 12 of Bibee's starts this season, and they went 4-8 in those games.

Orioles vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (52.7%)

Orioles vs Guardians Moneyline

• Baltimore is the favorite, -132 on the moneyline, while Cleveland is a +112 underdog on the road.

Orioles vs Guardians Spread

• The Guardians are +1.5 on the run line against the Orioles. The Guardians are -182 to cover, and the Orioles are +150.

Orioles vs Guardians Over/Under

• The over/under for Orioles-Guardians on Sept. 8 is 8.5. The over is -120, and the under is -102.

Bet on Baltimore Orioles vs. Cleveland Guardians on FanDuel today!

Orioles vs Guardians Betting Trends

• The Orioles have come away with 36 wins in the 67 contests they have been listed as the favorites in this season.
• Baltimore has a record of 19-16 in contests when sportsbooks favor them by -132 or more on the moneyline.
• Contests with the Orioles have gone over the total set by oddsmakers in 72 of 144 chances this season.
• The Orioles have posted a record of 74-70-0 against the spread this season.
• The Guardians are 26-27 in games they were the underdog on the moneyline (winning 49.1% of those games).
• When it has played as a moneyline underdog with odds of +112 or longer, Cleveland has gone 18-12 (60%).
• In the 137 games oddsmakers have set an over/under for the Guardians, they have combined with opponents to go over the total 66 times (66-71-0).
• The Guardians have a 64-73-0 record against the spread this season.

Orioles Player Leaders

• Pete Alonso has 144 hits and an OBP of .360 to go with a slugging percentage of .494. All three of those stats are tops among Baltimore hitters this season. He has a .266 batting average, as well.
• Among qualified batters in baseball, he is 51st in batting average, 30th in on-base percentage, and 16th in slugging.
• Gunnar Henderson is hitting .220 with 25 doubles, five triples, 22 home runs and 60 walks. He's slugging .397 with an on-base percentage of .303.
• Among qualifying batters, he is 126th in batting average, 117th in on-base percentage and 94th in slugging percentage.
• Coby Mayo has 79 hits this season and has a slash line of .224/.288/.460.
• Mayo brings a two-game hitting streak into this game. In his last five games he is hitting .333 with a double, two home runs, a walk and three RBIs.
• Leody Taveras has eight home runs, 52 RBI and a batting average of .216 this season.

Guardians Player Leaders

• Chase DeLauter has racked up 131 hits with a .458 slugging percentage, both team-best numbers for the Guardians. He's batting .294 and with an on-base percentage of .365.
• Including all qualified hitters in MLB, his batting average places him 10th, his on-base percentage ranks 23rd, and he is 41st in slugging.
• Jose Ramirez has 24 doubles, 11 home runs and 56 walks while batting .237. He's slugging .377 with an on-base percentage of .329.
• He is currently 107th in batting average, 71st in on-base percentage and 116th in slugging percentage among all qualified batters.
• Steven Kwan has racked up an on-base percentage of .373 and a slugging percentage of .335. Both lead the Guardians.
• Brayan Rocchio is batting .247 with 20 doubles, two triples, 13 home runs and 33 walks.

Orioles vs Guardians Head to Head

• 9/7/2026: 6-4 BAL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 4/19/2026: 8-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 4/18/2026: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 4/17/2026: 6-4 BAL (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/16/2026: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/24/2025: 4-3 BAL (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/23/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/22/2025: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/21/2025: 10-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 4/17/2025: 6-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)

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