Orioles vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 8

Odds updated as of 6:12 p.m.

MLB action on Tuesday includes the Baltimore Orioles playing the Cleveland Guardians.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this game.

Orioles vs Guardians Game Info

• Baltimore Orioles (70-75) vs. Cleveland Guardians (73-72)
• Date: Tuesday, September 8, 2026
• Time: 6:35 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN and CleGuardians.TV

Orioles vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-120) | CLE: (+102)
• Spread: BAL: +1.5 (-196) | CLE: -1.5 (+162)
• Total: 8 -- Over: (-112) | Under: (-108)

Orioles vs Guardians Probable Starting Pitchers

Probable Pitchers: Brandon Young (Orioles) - 9-3, 3.42 ERA vs Tanner Bibee (Guardians) - 5-15, 4.06 ERA

The probable pitchers are Brandon Young (9-3) for the Orioles and Tanner Bibee (5-15) for the Guardians. Young's team is 19-5-0 against the spread this season in his starts. When Young starts a game and his team is the favorite on the moneyline, they have a record of 8-3. The Guardians have a 6-21-0 ATS record in Bibee's 27 starts with a set spread. The Guardians have a 4-8 record in Bibee's 12 starts this season when they were the moneyline underdog.

Orioles vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (52.7%)

Orioles vs Guardians Moneyline

• Cleveland is a +102 underdog on the moneyline, while Baltimore is a -120 favorite at home.

Orioles vs Guardians Spread

• The Guardians are 1.5-run favorites against the spread for this matchup with the Orioles. The Guardians are +162 to cover, while the Orioles are -196 to cover as a 1.5-run underdog on the runline.

Orioles vs Guardians Over/Under

• The over/under for the Orioles versus Guardians game on Sept. 8 has been set at 8, with -112 odds on the over and -108 odds on the under.

Bet on Baltimore Orioles vs. Cleveland Guardians on FanDuel today!

Orioles vs Guardians Betting Trends

• The Orioles have been favorites in 67 games this season and have come away with the win 36 times (53.7%) in those contests.
• This season Baltimore has come away with a win 28 times in 53 chances when named as a favorite of at least -120 on the moneyline.
• The Orioles' games have gone over the total in 72 of their 144 opportunities.
• The Orioles are 74-70-0 against the spread in their 144 games that had a posted line this season.
• The Guardians are 26-27 in games they were the underdog on the moneyline (winning 49.1% of those games).
• Cleveland is 21-22 (winning 48.8% of its games) when it has played as a moneyline underdog of +102 or longer.
• The Guardians have combined with opponents to go over the total 66 times this season for a 66-71-0 record against the over/under.
• The Guardians have collected a 64-73-0 record against the spread this season (covering 46.7% of the time).

Orioles Player Leaders

• Pete Alonso leads Baltimore with 144 hits and an OBP of .360, plus a team-best slugging percentage of .494. He's batting .266.
• Among the qualifying hitters in MLB, his batting average ranks 51st, his on-base percentage ranks 30th, and he is 16th in slugging.
• Gunnar Henderson is batting .220 with 25 doubles, five triples, 22 home runs and 60 walks, while slugging .397 with an on-base percentage of .303.
• Among qualified batters, his batting average places him 126th, his on-base percentage 117th, and his slugging percentage 94th.
• Coby Mayo has 79 hits this season and has a slash line of .224/.288/.460.
• Mayo has picked up a hit in two straight games. During his last five outings he is hitting .333 with a double, two home runs, a walk and three RBIs.
• Leody Taveras is batting .216 with a .290 OBP and 52 RBI for Baltimore this season.

Guardians Player Leaders

• Chase DeLauter has racked up a team-best slugging percentage (.458) while leading the Guardians in hits (131). He's batting .294 and with an on-base percentage of .365.
• Including all qualified hitters in MLB, he ranks 10th in batting average, 23rd in on-base percentage and 41st in slugging percentage.
• Jose Ramirez is hitting .237 with 24 doubles, 11 home runs and 56 walks. He's slugging .377 with an on-base percentage of .329.
• He is currently 107th in batting average, 71st in on-base percentage and 116th in slugging percentage among all qualified hitters.
• Steven Kwan has racked up a team-best OBP (.373) and slugging percentage (.335).
• Brayan Rocchio is batting .247 with 20 doubles, two triples, 13 home runs and 33 walks.

Orioles vs Guardians Head to Head

• 9/7/2026: 6-4 BAL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 4/19/2026: 8-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 4/18/2026: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 4/17/2026: 6-4 BAL (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/16/2026: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/24/2025: 4-3 BAL (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/23/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/22/2025: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/21/2025: 10-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 4/17/2025: 6-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)

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