Orioles vs Blue Jays Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 22

Odds updated as of 1:11 a.m.

In MLB action on Tuesday, the Baltimore Orioles take on the Toronto Blue Jays.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding this matchup.

Orioles vs Blue Jays Game Info

• Baltimore Orioles (76-81) vs. Toronto Blue Jays (77-80)
• Date: Tuesday, September 22, 2026
• Time: 6:35 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN and SNET

Orioles vs Blue Jays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-120) | TOR: (+102)
• Spread: BAL: +1.5 (-220) | TOR: -1.5 (+180)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Orioles vs Blue Jays Probable Starting Pitchers

Probable Pitchers: Chris Bassitt (Orioles) - 8-5, 4.64 ERA vs Max Scherzer (Blue Jays) - 3-8, 6.07 ERA

The Orioles will give the ball to Chris Bassitt (8-5, 4.64 ERA), who is eyeing win No. 9 on the season, and the Blue Jays will turn to Max Scherzer (3-8, 6.07 ERA). Bassitt and his team have a record of 10-7-0 against the spread when he starts. When Bassitt starts a game and his team is the favorite on the moneyline, they have a record of 2-2. When Scherzer starts, the Blue Jays are 5-11-0 against the spread. The Blue Jays have been the moneyline underdog in 10 of Scherzer's starts this season, and they went 4-6 in those games.

Orioles vs Blue Jays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (58.3%)

Orioles vs Blue Jays Moneyline

• Looking at the moneyline for Blue Jays-Orioles, Toronto is the underdog at +102, and Baltimore is -120 playing at home.

Orioles vs Blue Jays Spread

• The Blue Jays are 1.5-run favorites against the spread for this matchup with the Orioles. The Blue Jays are +180 to cover, while the Orioles are -220 to cover as a 1.5-run underdog on the runline.

Orioles vs Blue Jays Over/Under

• The over/under for Orioles-Blue Jays on Sept. 22 is 7.5. The over is -115, and the under is -105.

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Orioles vs Blue Jays Betting Trends

• The Orioles have been chosen as favorites in 68 games this year and have walked away with the win 36 times (52.9%) in those games.
• Baltimore has a record of 28-26 in contests when oddsmakers favor them by -120 or more on the moneyline.
• Contests with the Orioles have gone over the total set by sportsbooks in 79 of 155 chances this season.
• The Orioles are 81-74-0 against the spread in their 155 games with a line set by sportsbooks this season.
• The Blue Jays have won 43.5% of the games this season they were the underdog on the moneyline (30-39).
• Toronto has a 21-26 record (winning 44.7% of its games) when playing as a moneyline underdog of +102 or longer.
• The Blue Jays have had an over/under set by oddsmakers 152 times, and have combined with opponents to go over the total in 80 of those games (80-70-2).
• The Blue Jays have gone 74-78-0 against the spread this season.

Orioles Player Leaders

• Pete Alonso leads Baltimore in OBP (.359), slugging percentage (.510) and total hits (156) this season. He has a .265 batting average.
• Among qualifying hitters in MLB, his batting average ranks 51st, his on-base percentage ranks 31st, and he is 13th in slugging.
• Gunnar Henderson is batting .227 with 27 doubles, six triples, 24 home runs and 65 walks. He's slugging .408 with an on-base percentage of .310.
• He ranks 117th in batting average, 104th in on-base percentage and 79th in slugging among qualifying hitters.
• Coby Mayo has 90 hits this season and has a slash line of .227/.295/.466.
• Leody Taveras has been key for Baltimore with 91 hits, an OBP of .286 plus a slugging percentage of .339.

Blue Jays Player Leaders

• Vladimir Guerrero Jr. has accumulated an on-base percentage of .336, a team-best for the Blue Jays. He's batting .263 and slugging .359.
• Including all qualifying hitters in the big leagues, he ranks 56th in batting average, 61st in on-base percentage and 123rd in slugging percentage.
• Guerrero hopes to build on a four-game hitting streak in this matchup. During his last five outings he is batting .267 with three walks.
• Kazuma Okamoto's 130 hits lead his team. He has a batting average of .235 while slugging .458 with an on-base percentage of .310.
• His batting average ranks 105th among all qualified players, his on-base percentage ranks 104th, and he is 37th in slugging.
• Ernie Clement has put up a slugging percentage of .370, a team-best for the Blue Jays.
• George Springer has 22 doubles, two triples, 15 home runs and 47 walks while hitting .251.

Orioles vs Blue Jays Head to Head

• 9/13/2026: 8-1 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/12/2026: 7-3 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/11/2026: 7-4 BAL (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/7/2026: 6-4 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/6/2026: 6-4 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/5/2026: 13-3 BAL (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/31/2026: 9-5 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/30/2026: 6-5 BAL (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/29/2026: 6-5 TOR (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/28/2026: 2-1 TOR (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)

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