Orioles vs Blue Jays Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 22

Odds updated as of 1:11 p.m.

The Baltimore Orioles are among the MLB teams playing on Wednesday, up against the Toronto Blue Jays.

We've got you covered, in terms of the most important information about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Orioles vs Blue Jays Game Info

• Baltimore Orioles (76-81) vs. Toronto Blue Jays (77-80)
• Date: Wednesday, September 23, 2026
• Time: 1:35 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN and SNET

Orioles vs Blue Jays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-126) | TOR: (+108)
• Spread: BAL: -1.5 (+172) | TOR: +1.5 (-210)
• Total: 7.5 -- Over: (+116) | Under: (-142)

Orioles vs Blue Jays Probable Starting Pitchers

Probable Pitchers: Chris Bassitt (Orioles) - 8-5, 4.64 ERA vs Max Scherzer (Blue Jays) - 3-8, 6.07 ERA

The Orioles will give the ball to Chris Bassitt (8-5, 4.64 ERA), who is eyeing win No. 9 on the season, and the Blue Jays will counter with Max Scherzer (3-8, 6.07 ERA). Bassitt and his team are 10-7-0 ATS this season when he starts. Bassitt's team has won 50% of his starts when they are favored on the moneyline (2-2). The Blue Jays are 5-11-0 ATS in Scherzer's 16 starts that had a set spread. The Blue Jays are 4-6 in Scherzer's 10 starts this season that they were the underdog on the moneyline.

Orioles vs Blue Jays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (58.8%)

Orioles vs Blue Jays Moneyline

• Toronto is a +108 underdog on the moneyline, while Baltimore is a -126 favorite at home.

Orioles vs Blue Jays Spread

• The Blue Jays are at +1.5 on the runline against the Orioles. The Blue Jays are -210 to cover the spread, and the Orioles are +172.

Orioles vs Blue Jays Over/Under

• The Orioles-Blue Jays contest on Sept. 23 has been given an over/under of 7.5 runs. The over is set at +116 and the under at -142.

Bet on Baltimore Orioles vs. Toronto Blue Jays on FanDuel today!

Orioles vs Blue Jays Betting Trends

• The Orioles have been favorites in 68 games this season and have come away with the win 36 times (52.9%) in those contests.
• This season Baltimore has been victorious 24 times in 47 chances when named as a favorite of at least -126 on the moneyline.
• The Orioles' games have gone over the total in 79 of their 155 opportunities.
• In 155 games with a line this season, the Orioles have a mark of 81-74-0 against the spread.
• The Blue Jays have been the underdog on the moneyline 69 total times this season. They've finished 30-39 in those games.
• In games it has played as a moneyline underdog with odds of +108 or longer, Toronto has a 17-23 record (winning 42.5% of its games).
• The Blue Jays have had an over/under set by oddsmakers 152 times, and have combined with opponents to go over the total in 80 of those games (80-70-2).
• The Blue Jays have put together a 74-78-0 record against the spread this season (covering 48.7% of the time).

Orioles Player Leaders

• Pete Alonso leads Baltimore in OBP (.359), slugging percentage (.510) and total hits (156) this season. He has a .265 batting average.
• Among all qualified hitters, he ranks 50th in batting average, his on-base percentage ranks 31st, and he is 11th in slugging.
• Gunnar Henderson is batting .227 with 27 doubles, six triples, 24 home runs and 65 walks. He's slugging .408 with an on-base percentage of .310.
• Among all qualified batters, he is 119th in batting average, 103rd in on-base percentage and 83rd in slugging percentage.
• Coby Mayo has 90 hits this season and has a slash line of .227/.295/.466.
• Leody Taveras is batting .216 with a .286 OBP and 54 RBI for Baltimore this season.

Blue Jays Player Leaders

• Vladimir Guerrero Jr. has put up an on-base percentage of .336, a team-high for the Blue Jays. He's batting .263 and slugging .359.
• Including all qualified hitters in the majors, he is 55th in batting average, 60th in on-base percentage and 121st in slugging percentage.
• Guerrero hopes to build on a four-game hitting streak in this matchup. During his last five outings he is hitting .267 with three walks.
• Kazuma Okamoto's 130 hits lead his team. He has a batting average of .235 while slugging .458 with an on-base percentage of .310.
• His batting average is 103rd among all qualified players, his on-base percentage ranks 103rd, and he is 38th in slugging.
• Ernie Clement has accumulated a slugging percentage of .370, a team-best for the Blue Jays.
• George Springer is batting .251 with 22 doubles, two triples, 15 home runs and 47 walks.

Orioles vs Blue Jays Head to Head

• 9/13/2026: 8-1 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/12/2026: 7-3 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/11/2026: 7-4 BAL (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/7/2026: 6-4 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/6/2026: 6-4 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/5/2026: 13-3 BAL (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/31/2026: 9-5 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/30/2026: 6-5 BAL (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/29/2026: 6-5 TOR (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/28/2026: 2-1 TOR (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)

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