Oregon vs USC Prediction, Odds, Picks, Best Bets for Week 4 2026

Saturday's slate in college football includes a matchup between the Oregon Ducks and the USC Trojans.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Oregon vs USC Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Oregon: (-170) | USC: (+140)
• Spread: Oregon: -3.5 (-106) | USC: +3.5 (-114)
• Total: 61.5 -- Over: (-110) | Under: (-110)

Oregon vs USC Betting Trends

• Oregon has posted one win against the spread this season.
• As a 3.5-point or greater favorite, Oregon has one win ATS (1-2) this season.
• Every Oregon game has hit the over this year.
• USC has one win against the spread this season.
• This year, three of USC's four games have gone over the point total.

Oregon vs USC Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Ducks win (54.8%)

Oregon vs USC Point Spread

Oregon is favored by 3.5 points over USC. Oregon is -106 to cover the spread, with USC being -114.

Oregon vs USC Over/Under

Oregon versus USC on Sept. 26 has an over/under of 61.5 points, with the over -110 and the under -110.

Oregon vs USC Moneyline

The Oregon vs USC moneyline has Oregon as a -170 favorite, while USC is a +140 underdog.

Oregon vs. USC Points Insights

Oregon vs. USC Game Info

• Game day: Saturday, September 26, 2026
• Game time: 7:30 p.m. ET
• TV channel: NBC
• Location: Los Angeles, California
• Stadium: Los Angeles Memorial Coliseum

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Check out even more in-depth Oregon vs. USC analysis on FanDuel Research.