Ole Miss vs Louisville Prediction, Odds, Picks, Best Bets for Week 1 2026

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The Sunday schedule in college football includes a matchup between the Ole Miss Rebels and the Louisville Cardinals.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Ole Miss vs Louisville Odds & Spread

All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
Moneyline: Ole Miss: (-250) | Louisville: (+205)
Spread: Ole Miss: -6.5 (-118) | Louisville: +6.5 (-104)
Total: 54.5 -- Over: (-115) | Under: (-105)

Ole Miss covered the spread nine times in 15 games last season.
Ole Miss went 5-4 as at least 6.5-point favorites last season.
There were eight Ole Miss games (out of 15) that went over the total last season.
Against the spread, Louisville was 4-9-0 last year.
Louisville covered every time (1-0) as underdogs of 6.5 points or greater last year.
Out of 13 Louisville games last season, six hit the over.

All college football win probability predictions and picks are according to numberFire.
Prediction: Rebels win (61.2%)

Ole Miss is favored by 6.5 points versus Louisville. Ole Miss is -118 to cover the spread, while Louisville is -104.

Ole Miss versus Louisville, on Sept. 6, has an over/under of 54.5, with the over being -115 and the under -105.

The moneyline numbers for Ole Miss vs. Louisville reveal Ole Miss as the favorite (-250) and Louisville as the underdog (+205).

The Rebels' average implied point total last season was 4.9 more points than their implied total in Sunday's game (35.9 implied points on average compared to 31 implied points in this game).
The Cardinals' average implied point total last season (32.9 points) is 8.9 points higher than their implied total in this matchup (24 points).

Check out even more in-depth Ole Miss vs. Louisville analysis on FanDuel Research.

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