Ole Miss vs Louisville Prediction, Odds, Picks, Best Bets for Week 1 2026

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The Sunday slate in college football includes a matchup between the Ole Miss Rebels and the Louisville Cardinals.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Ole Miss vs Louisville Odds & Spread

All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
Moneyline: Ole Miss: (-265) | Louisville: (+215)
Spread: Ole Miss: -6.5 (-122) | Louisville: +6.5 (100)
Total: 54.5 -- Over: (-115) | Under: (-105)

Against the spread, Ole Miss went 9-6-0 last season.
As 6.5-point or greater favorites last season, Ole Miss went 5-4.
In 15 Ole Miss games last season, eight went over the total.
Louisville posted a 4-9-0 record against the spread last season.
Louisville went unbeaten ATS (1-0) as underdogs of 6.5 points or greater last year.
Out of 13 Louisville games last year, six hit the over.

All college football win probability predictions and picks are according to numberFire.
Prediction: Rebels win (69%)

Louisville is an underdog by 6.5 points against Ole Miss. Louisville is +100 to cover the spread, and Ole Miss is -122.

The over/under for Ole Miss-Louisville on Sept. 6 is 54.5. The over is -115, and the under is -105.

The moneyline numbers for Ole Miss vs. Louisville reveal Ole Miss as the favorite (-265) and Louisville as the underdog (+215).

The average implied total for the Rebels last season was 35.9 points, 4.9 more points than their implied total of 31 points in Sunday's game.
The 32.9-point average implied total last season for the Cardinals is 8.9 more points than the team's 24-point implied total in this matchup.

Check out even more in-depth Ole Miss vs. Louisville analysis on FanDuel Research.

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