Notre Dame vs Michigan State Prediction, Odds, Picks, Best Bets for Week 3 2026

Saturday's slate in college football includes a matchup between the Notre Dame Fighting Irish and the Michigan State Spartans.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding today's NCAA football betting odds.

Notre Dame vs Michigan State Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Notre Dame: (-7143) | Michigan State: (+2000)
• Spread: Notre Dame: -29.5 (-106) | Michigan State: +29.5 (-114)
• Total: 52.5 -- Over: (-105) | Under: (-115)

Notre Dame vs Michigan State Betting Trends

• Notre Dame has posted two wins against the spread this year.
• Notre Dame has yet to lose ATS (1-0) as a 29.5-point favorite or greater this season.
• One of Notre Dame's two games this season has hit the over.
• Michigan State has but one win versus the spread this year.
• Michigan State has had one game (of two) go over the total this season.

Notre Dame vs Michigan State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Fighting Irish win (96%)

Notre Dame vs Michigan State Point Spread

Notre Dame is favored by 29.5 points (-106 to cover) in this matchup. Michigan State, the underdog, is -114.

Notre Dame vs Michigan State Over/Under

A total of 52.5 points has been set for the Notre Dame-Michigan State game on Sept. 19, with the over available at -105 and the under at -115.

Notre Dame vs Michigan State Moneyline

Looking at the moneyline for Michigan State-Notre Dame, Michigan State is the underdog at +2000, and Notre Dame is -7143.

Notre Dame vs. Michigan State Points Insights

Notre Dame vs. Michigan State Game Info

• Game day: Saturday, September 19, 2026
• Game time: 7:30 p.m. ET
• TV channel: NBC/Peacock
• Location: South Bend, Indiana
• Stadium: Notre Dame Stadium

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Notre Dame vs. Michigan State analysis on FanDuel Research.