Notre Dame vs Michigan State Prediction, Odds, Picks, Best Bets for Week 3 2026

The Notre Dame Fighting Irish versus the Michigan State Spartans is on the college football schedule for Saturday.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Notre Dame vs Michigan State Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Notre Dame: (-10000) | Michigan State: (+2500)
• Spread: Notre Dame: -29.5 (-110) | Michigan State: +29.5 (-110)
• Total: 52.5 -- Over: (-110) | Under: (-110)

Notre Dame vs Michigan State Betting Trends

• Notre Dame has posted two wins against the spread this season.
• Notre Dame is unbeaten ATS (1-0) as a 29.5-point favorite or greater this season.
• One of two Notre Dame games have gone over the point total this year.
• Michigan State has but one win versus the spread this year.
• One of Michigan State's two games has hit the over.

Notre Dame vs Michigan State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Fighting Irish win (96.7%)

Notre Dame vs Michigan State Point Spread

Notre Dame is favored by 29.5 points versus Michigan State. Notre Dame is -110 to cover the spread, while Michigan State is -110.

Notre Dame vs Michigan State Over/Under

A combined point total of 52.5 has been set for Notre Dame-Michigan State on Sept. 19, with the over at -110 and the under at -110.

Notre Dame vs Michigan State Moneyline

Michigan State is the underdog, +2500 on the moneyline, while Notre Dame is a -10000 favorite.

Notre Dame vs. Michigan State Points Insights

Notre Dame vs. Michigan State Game Info

• Game day: Saturday, September 19, 2026
• Game time: 7:30 p.m. ET
• TV channel: NBC/Peacock
• Location: South Bend, Indiana
• Stadium: Notre Dame Stadium

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Check out even more in-depth Notre Dame vs. Michigan State analysis on FanDuel Research.