Northwestern vs Colorado Prediction, Odds, Picks, Best Bets for Week 3 2026

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The college football slate on Saturday includes the Northwestern Wildcats facing the Colorado Buffaloes.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Northwestern vs Colorado Odds & Spread

All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
Moneyline: Northwestern: (-176) | Colorado: (+146)
Spread: Northwestern: -3.5 (-110) | Colorado: +3.5 (-110)
Total: 48.5 -- Over: (-105) | Under: (-115)

Northwestern has posted one win against the spread this year.
Northwestern is unbeaten ATS (1-0) as a 3.5-point favorite or greater this season.
Northwestern and its opponent have not failed to hit the over in any game this season.
Colorado has one win against the spread this season.
Colorado has covered every time (1-0) as a 3.5-point or greater underdog this season.
One Colorado game (out of two) has hit the over this season.

All college football win probability predictions and picks are according to numberFire.
Prediction: Wildcats win (80.3%)

Colorado is an underdog by 3.5 points against Northwestern. Colorado is -110 to cover the spread, and Northwestern is -110.

The over/under for the Northwestern versus Colorado game on Sept. 19 has been set at 48.5, with -105 odds on the over and -115 odds on the under.

The Northwestern vs Colorado moneyline has Northwestern as a -176 favorite, while Colorado is a +146 underdog.

The Wildcats had an average implied point total of 29.3 last season, which is 3.3 points higher than their implied total in Saturday's game (26).
The 29.9-point average implied total last season for the Buffaloes is 6.9 more points than the team's 23-point implied total in this matchup.

Check out even more in-depth Northwestern vs. Colorado analysis on FanDuel Research.

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