MLB Predictions Today: 3 MLB Best Bets and Picks for Friday, September 25, 2026

Today’s Best MLB Betting Picks in Summary

• Rangers-Twins NRFI (-142)
• Isaac Paredes to Record an RBI (+125)
• Angels-Mariners NRFI (-150)

Baseball has you covered if you want a large inventory of options to bet.

From moneylines to player props to NRFI wagers, we have plenty of ways each day to bet the long, arduous MLB schedule.

Using the MLB odds at FanDuel Sportsbook, what are the best MLB bets for today?

This article includes some of the top bets from our other MLB content. All MLB odds via FanDuel, and they may change after this article is published.

MLB Picks and Predictions for Today

Rangers-Twins NRFI (-142)

Rangers at Twins, 8:10 p.m. ET

Jacob deGrom against Joe Ryan is the kind of pitching matchup that immediately puts a game on the NRFI radar.

Ryan has registered a 3.73 xERA this season while striking out 25.7% of hitters and walking only 5.1%. That low walk rate is particularly useful for NRFI purposes because it forces the Texas Rangers to string together hits to generate a first-inning run.

DeGrom remains capable of overpowering any lineup, and his matchup with the Minnesota Twins gives this bet quality starting pitching on both sides. He enters Friday with 147 strikeouts over 120.2 innings this season, giving him plenty of bat-missing upside against the top of the Twins' order.

Ryan's command paired with deGrom's strikeout ability makes this one of my preferred NRFIs on Friday.

Isaac Paredes to Record an RBI (+125)

Astros vs. Athletics, 9:41 p.m. ET

Prior to this season, Jacob Lopez was a southpaw who I thought might be on track to become a very good pitcher. It’s gone the other way in 2026, though, and Isaac Paredes can cook in this matchup.

Lopez produced a 3.76 SIERA a year ago, striking out 28.3% of hitters. Those numbers have plummeted to a 4.84 SIERA and 20.4% K rate this season. Righties have a .376 wOBA against him, and Lopez has permitted 2.04 home runs per nine in the split. Add in homer-happy Sutter Health Park, and this is a nice spot for the Houston Astros.

Paredes will have the platoon advantage versus Lopez, and he’s amassed a .348 wOBA and 49.6% fly-ball rate against LHPs this year. He’s got seven RBI across his past six games, and once Lopez departs, Paredes will see an A’s bullpen that has the seventh-worst expected ERA in 2026.

Angels-Mariners NRFI (-150)

Angels at Mariners, 10:10 p.m. ET

Reid Detmers' 2026 breakout gives us another appealing late-night NRFI opportunity.

Detmers owns a 3.47 ERA and an even better 3.23 xERA across 179 innings. He's struck out 28.4% of hitters while issuing walks at only a 6.4% clip, and opposing hitters have managed just a .279 xwOBA against him. Those are strong indicators for getting through the Seattle Mariners‘ first three hitters without damage.

Bryce Miller hasn't been quite as dominant, but he's been solid enough to hold up his end of the wager. Miller carries a 3.99 ERA over 112.2 innings while striking out 112 hitters against 36 walks. He also enters this start off an encouraging outing in which he didn't allow an earned run across 5.1 frames.

Detmers is the pitcher I trust more in this matchup, but Miller's combination of control and recent form makes the other half of the equation viable, as well.

With two capable starters taking the ball at pitcher-friendly T-Mobile Park, Angels-Mariners is another NRFI worth considering on Friday.

MLB Betting Frequently Asked Questions

What are MLB player prop bets?

MLB player prop bets are wagers on specific statistical outcomes tied to individual players during a game — not on which team wins or loses. You might bet on how many strikeouts a starting pitcher records, whether a shortstop gets a hit, or how many total bases an outfielder accumulates.

Because they are isolated to a single player's performance, props let you apply focused knowledge about matchups, recent form, and ballpark conditions rather than predicting the full game result.

What types of MLB player props are available?

FanDuel offers a wide menu of MLB props. The most common categories include:

• Pitcher strikeouts
• Batter hits
• Home runs
• Total bases
• RBIs
• Stolen bases
• Pitcher outs recorded

What does +310 mean on an MLB home run prop bet?

A +310 line means a $100 bet returns $310 in profit if the player homers. You can bet any amount — a $10 bet at +310 returns $31 in profit. The number reflects the implied probability the sportsbook assigns to the event (roughly 24% for +310 odds).

What does "total bases" mean as a prop bet?

The total bases prop counts the bases a batter earns from hits in a single game:

• Single = 1 base
• Double = 2 bases
• Triple = 3 bases
• Home run = 4 bases

Walks, hit-by-pitches, and stolen bases do not count. A typical total bases line is set at 1.5 or 2.5. Betting over 1.5 means you need at least a double, or two singles.

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Which MLB bets stand out to you today? Check out FanDuel Sportsbook's MLB odds to see the full menu of options.

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The above author is a FanDuel employee and is not eligible to compete in public daily fantasy contests or place sports betting wagers on FanDuel. The advice provided by the author does not necessarily represent the views of FanDuel. Taking the author’s advice will not guarantee a successful outcome. You should use your own judgment when participating in daily fantasy contests or placing sports wagers.