Friday’s MLB Odds, Betting Lines and Predictions - Sept. 25

The Chicago Cubs and the Boston Red Sox square off for one of many exciting matchups on the MLB schedule today. We have predictions for every game in the article below, so take a look.

Today's MLB Odds and Predictions

Chicago Cubs at Boston Red Sox Odds, Lines & Predictions

Game Info

• When: 1:05 p.m. ET
• Where: Fenway Park
• TV Channel: NESN and MARQ
• Probable Pitchers: Alec Gamboa vs. Clay Holmes
• Records: Red Sox (87-74), Cubs (88-73)
• Cubs Moneyline Odds: -120
• Red Sox Moneyline Odds: +102

numberFire Prediction

• numberFire Predicted Favorite: Cubs
• Cubs Win Probability: 56.27%
• Red Sox Win Probability: 43.73%

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Baltimore Orioles at New York Yankees Odds, Lines & Predictions

Game Info

• When: 4:05 p.m. ET
• Where: Yankee Stadium
• TV Channel: YES and MASN
• Probable Pitchers: Brendan Beck vs. Trevor Rogers
• Records: Yankees (92-68), Orioles (79-81)
• Orioles Moneyline Odds: -110
• Yankees Moneyline Odds: -106

numberFire Prediction

• numberFire Predicted Favorite: Yankees
• Yankees Win Probability: 51.26%
• Orioles Win Probability: 48.74%

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Chicago Cubs at Boston Red Sox Odds, Lines & Predictions

Game Info

• When: 5:35 p.m. ET
• Where: Fenway Park
• TV Channel: NESN and MARQ
• Probable Pitchers: Brayan Bello vs. David Peterson
• Records: Red Sox (87-74), Cubs (88-73)
• Cubs Moneyline Odds: -118
• Red Sox Moneyline Odds: +100

numberFire Prediction

• numberFire Predicted Favorite: Cubs
• Cubs Win Probability: 54.28%
• Red Sox Win Probability: 45.72%

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Tampa Bay Rays at Philadelphia Phillies Odds, Lines & Predictions

Game Info

• When: 6:40 p.m. ET
• Where: Citizens Bank Park
• TV Channel: NBCS-PH and RAYS
• Probable Pitchers: Cristopher Sanchez vs. Freddy Peralta
• Records: Phillies (87-73), Rays (97-63)
• Phillies Moneyline Odds: -178
• Rays Moneyline Odds: +150

numberFire Prediction

• numberFire Predicted Favorite: Phillies
• Phillies Win Probability: 54.74%
• Rays Win Probability: 45.26%

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Pittsburgh Pirates at Detroit Tigers Odds, Lines & Predictions

Game Info

• When: 6:40 p.m. ET
• Where: Comerica Park
• TV Channel: DSN and SportsNet PT
• Probable Pitchers: Jackson Jobe vs. Bubba Chandler
• Records: Tigers (74-85), Pirates (81-78)
• Tigers Moneyline Odds: -120
• Pirates Moneyline Odds: +102

numberFire Prediction

• numberFire Predicted Favorite: Tigers
• Tigers Win Probability: 51.73%
• Pirates Win Probability: 48.27%

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New York Mets at Washington Nationals Odds, Lines & Predictions

Game Info

• When: 6:45 p.m. ET
• Where: Nationals Park
• TV Channel: NATS and WPIX
• Probable Pitchers: Andrew Alvarez vs. Jefry Yan
• Records: Nationals (75-84), Mets (73-86)
• Nationals Moneyline Odds: -112
• Mets Moneyline Odds: -104

numberFire Prediction

• numberFire Predicted Favorite: Nationals
• Nationals Win Probability: 56.21%
• Mets Win Probability: 43.79%

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Cincinnati Reds at Toronto Blue Jays Odds, Lines & Predictions

Game Info

• When: 7:07 p.m. ET
• Where: Rogers Centre
• TV Channel: SNET and CINR
• Probable Pitchers: José Soriano vs. Nick Lodolo
• Records: Blue Jays (77-82), Reds (74-85)
• Blue Jays Moneyline Odds: -156
• Reds Moneyline Odds: +132

numberFire Prediction

• numberFire Predicted Favorite: Blue Jays
• Blue Jays Win Probability: 64.59%
• Reds Win Probability: 35.41%

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Atlanta Braves at Miami Marlins Odds, Lines & Predictions

Game Info

• When: 7:10 p.m. ET
• Where: loanDepot park
• TV Channel: MIAM and BravesVsn
• Probable Pitchers: Eury Pérez vs. Ray Kerr
• Records: Marlins (79-81), Braves (93-67)
• Braves Moneyline Odds: -120
• Marlins Moneyline Odds: +102

numberFire Prediction

• numberFire Predicted Favorite: Marlins
• Marlins Win Probability: 51.18%
• Braves Win Probability: 48.82%

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Baltimore Orioles at New York Yankees Odds, Lines & Predictions

Game Info

• When: 7:30 p.m. ET
• Where: Yankee Stadium
• TV Channel: YES and MASN
• Probable Pitchers: vs. Brandon Young
• Records: Yankees (92-68), Orioles (79-81)
• Yankees Moneyline Odds: -108
• Orioles Moneyline Odds: -108

numberFire Prediction

• numberFire Predicted Favorite: Yankees
• Yankees Win Probability: 61.49%
• Orioles Win Probability: 38.51%

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Cleveland Guardians at Kansas City Royals Odds, Lines & Predictions

Game Info

• When: 7:40 p.m. ET
• Where: Kauffman Stadium
• TV Channel: ROYL and CLEG
• Probable Pitchers: Noah Cameron vs. Gavin Williams
• Records: Royals (68-91), Guardians (83-76)
• Guardians Moneyline Odds: -142
• Royals Moneyline Odds: +120

numberFire Prediction

• numberFire Predicted Favorite: Guardians
• Guardians Win Probability: 54.43%
• Royals Win Probability: 45.57%

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Colorado Rockies at Chicago White Sox Odds, Lines & Predictions

Game Info

• When: 7:40 p.m. ET
• Where: Rate Field
• TV Channel: CHSN and COLR
• Probable Pitchers: Sean Burke vs. Tomoyuki Sugano
• Records: White Sox (82-77), Rockies (57-102)
• White Sox Moneyline Odds: -250
• Rockies Moneyline Odds: +205

numberFire Prediction

• numberFire Predicted Favorite: White Sox
• White Sox Win Probability: 68.12%
• Rockies Win Probability: 31.88%

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St. Louis Cardinals at Milwaukee Brewers Odds, Lines & Predictions

Game Info

• When: 7:40 p.m. ET
• Where: American Family Field
• TV Channel: BREW and CARD
• Probable Pitchers: Robert Gasser vs. Michael McGreevy
• Records: Brewers (100-59), Cardinals (77-82)
• Brewers Moneyline Odds: -188
• Cardinals Moneyline Odds: +158

numberFire Prediction

• numberFire Predicted Favorite: Brewers
• Brewers Win Probability: 65.17%
• Cardinals Win Probability: 34.83%

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Texas Rangers at Minnesota Twins Odds, Lines & Predictions

Game Info

• When: 8:10 p.m. ET
• Where: Target Field
• TV Channel: MNNT and RSN
• Probable Pitchers: Joe Ryan vs. Jacob deGrom
• Records: Twins (75-84), Rangers (79-80)
• Rangers Moneyline Odds: -124
• Twins Moneyline Odds: +106

numberFire Prediction

• numberFire Predicted Favorite: Twins
• Twins Win Probability: 51.11%
• Rangers Win Probability: 48.89%

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Houston Astros at Athletics Odds, Lines & Predictions

Game Info

• When: 9:40 p.m. ET
• Where: Sutter Health Park
• TV Channel: NBCS-CA and SCHN
• Probable Pitchers: Jacob Lopez vs. Hunter Brown
• Records: Athletics (63-96), Astros (79-80)
• Astros Moneyline Odds: -190
• Athletics Moneyline Odds: +160

numberFire Prediction

• numberFire Predicted Favorite: Astros
• Astros Win Probability: 51.15%
• Athletics Win Probability: 48.85%

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Arizona Diamondbacks at San Diego Padres Odds, Lines & Predictions

Game Info

• When: 9:40 p.m. ET
• Where: Petco Park
• TV Channel: SDPA and ARID
• Probable Pitchers: Casey Mize vs. Brandon Pfaadt
• Records: Padres (89-70), Diamondbacks (85-74)
• Padres Moneyline Odds: -120
• Diamondbacks Moneyline Odds: +102

numberFire Prediction

• numberFire Predicted Favorite: Padres
• Padres Win Probability: 60.72%
• Diamondbacks Win Probability: 39.28%

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Los Angeles Angels at Seattle Mariners Odds, Lines & Predictions

Game Info

• When: 10:10 p.m. ET
• Where: T-Mobile Park
• TV Channel: SEAM and ABTV
• Probable Pitchers: Bryce Miller vs. Reid Detmers
• Records: Mariners (74-85), Angels (61-98)
• Mariners Moneyline Odds: -118
• Angels Moneyline Odds: +100

numberFire Prediction

• numberFire Predicted Favorite: Mariners
• Mariners Win Probability: 50.61%
• Angels Win Probability: 49.39%

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Los Angeles Dodgers at San Francisco Giants Odds, Lines & Predictions

Game Info

• When: 10:15 p.m. ET
• Where: Oracle Park
• TV Channel: NBCS-BA and SportsNet LA
• Probable Pitchers: Yunior Marté vs. Tarik Skubal
• Records: Giants (65-94), Dodgers (97-62)
• Dodgers Moneyline Odds: -330
• Giants Moneyline Odds: +265

numberFire Prediction

• numberFire Predicted Favorite: Dodgers
• Dodgers Win Probability: 65.91%
• Giants Win Probability: 34.09%

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All MLB win probability predictions and picks are according to numberFire.